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Protein

Zinc transporter 2

Gene

Slc30a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in accumulation of zinc in endosomal/lysosomal vesicles.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-RNO-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.3.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 2
Short name:
ZnT-2
Alternative name(s):
Solute carrier family 30 member 2
Gene namesi
Name:Slc30a2
Synonyms:Znt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3707. Slc30a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 86VacuolarSequence analysis9
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 123CytoplasmicSequence analysisAdd BLAST16
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 159VacuolarSequence analysisAdd BLAST15
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 207CytoplasmicSequence analysisAdd BLAST27
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 236VacuolarSequence analysis8
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 291CytoplasmicSequence analysisAdd BLAST34
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 359VacuolarSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060951 – 359Zinc transporter 2Add BLAST359

Proteomic databases

PaxDbiQ62941.
PRIDEiQ62941.

Expressioni

Tissue specificityi

Intestine, kidney, seminal vesicles and testis.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067545.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 1925 X 2 AA approximate repeats of H-G10

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
HOVERGENiHBG003345.
InParanoidiQ62941.
KOiK14689.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRSFFGAL WKSEASRIPP VNLPSVELAV QSNHYCHAQK DSGSHPNSEK
60 70 80 90 100
QRARRKLYVA SAICLVFMIG EIIGGYLAQS LAIMTDAAHL LTDFASMLIS
110 120 130 140 150
LFSLWVSSRP ATKTMNFGWQ RAEILGALLS VLSIWVVTGV LVYLAVQRLI
160 170 180 190 200
SGDYEIKGDT MLITSGCAVA VNIIMGLALH QSGHGHSHGH SHEDSSQQQQ
210 220 230 240 250
NPSVRAAFIH VVGDLLQSVG VLVAAYIIYF KPEYKYVDPI CTFLFSILVL
260 270 280 290 300
GTTLTILRDV ILVLMEGTPK GVDFTTVKNL LLSVDGVEAL HSLHIWALTV
310 320 330 340 350
AQPVLSVHIA IAQNVDAQAV LKVARDRLQG KFNFHTMTIQ IESYSEDMKS

CQECQGPSE
Length:359
Mass (Da):39,277
Last modified:November 1, 1996 - v1
Checksum:i256A307021D1D197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50927 mRNA. Translation: AAB02775.1.
PIRiS70632.
RefSeqiNP_037022.1. NM_012890.2.
UniGeneiRn.11135.

Genome annotation databases

GeneIDi25362.
KEGGirno:25362.
UCSCiRGD:3707. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50927 mRNA. Translation: AAB02775.1.
PIRiS70632.
RefSeqiNP_037022.1. NM_012890.2.
UniGeneiRn.11135.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067545.

Protein family/group databases

TCDBi2.A.4.3.1. the cation diffusion facilitator (cdf) family.

Proteomic databases

PaxDbiQ62941.
PRIDEiQ62941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25362.
KEGGirno:25362.
UCSCiRGD:3707. rat.

Organism-specific databases

CTDi7780.
RGDi3707. Slc30a2.

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
HOVERGENiHBG003345.
InParanoidiQ62941.
KOiK14689.

Enzyme and pathway databases

ReactomeiR-RNO-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ62941.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT2_RAT
AccessioniPrimary (citable) accession number: Q62941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.