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Protein

Zinc transporter 2

Gene

Slc30a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in accumulation of zinc in endosomal/lysosomal vesicles.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: RGD

GO - Biological processi

  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc ion transport Source: RGD

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

TCDBi2.A.4.3.1 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 2
Short name:
ZnT-2
Alternative name(s):
Solute carrier family 30 member 2
Gene namesi
Name:Slc30a2
Synonyms:Znt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3707 Slc30a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 86VacuolarSequence analysis9
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 123CytoplasmicSequence analysisAdd BLAST16
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 159VacuolarSequence analysisAdd BLAST15
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 207CytoplasmicSequence analysisAdd BLAST27
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 236VacuolarSequence analysis8
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 291CytoplasmicSequence analysisAdd BLAST34
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 359VacuolarSequence analysisAdd BLAST47

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060951 – 359Zinc transporter 2Add BLAST359

Proteomic databases

PaxDbiQ62941
PRIDEiQ62941

Expressioni

Tissue specificityi

Intestine, kidney, seminal vesicles and testis.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067545

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 1925 X 2 AA approximate repeats of H-G10

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
HOVERGENiHBG003345
InParanoidiQ62941
KOiK14689

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q62941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRSFFGAL WKSEASRIPP VNLPSVELAV QSNHYCHAQK DSGSHPNSEK
60 70 80 90 100
QRARRKLYVA SAICLVFMIG EIIGGYLAQS LAIMTDAAHL LTDFASMLIS
110 120 130 140 150
LFSLWVSSRP ATKTMNFGWQ RAEILGALLS VLSIWVVTGV LVYLAVQRLI
160 170 180 190 200
SGDYEIKGDT MLITSGCAVA VNIIMGLALH QSGHGHSHGH SHEDSSQQQQ
210 220 230 240 250
NPSVRAAFIH VVGDLLQSVG VLVAAYIIYF KPEYKYVDPI CTFLFSILVL
260 270 280 290 300
GTTLTILRDV ILVLMEGTPK GVDFTTVKNL LLSVDGVEAL HSLHIWALTV
310 320 330 340 350
AQPVLSVHIA IAQNVDAQAV LKVARDRLQG KFNFHTMTIQ IESYSEDMKS

CQECQGPSE
Length:359
Mass (Da):39,277
Last modified:November 1, 1996 - v1
Checksum:i256A307021D1D197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50927 mRNA Translation: AAB02775.1
PIRiS70632
RefSeqiNP_037022.1, NM_012890.2
UniGeneiRn.11135

Genome annotation databases

GeneIDi25362
KEGGirno:25362
UCSCiRGD:3707 rat

Similar proteinsi

Entry informationi

Entry nameiZNT2_RAT
AccessioniPrimary (citable) accession number: Q62941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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