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Protein

Disks large homolog 3

Gene

Dlg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.By similarity

GO - Molecular functioni

  • guanylate kinase activity Source: GO_Central
  • ionotropic glutamate receptor binding Source: RGD
  • PDZ domain binding Source: RGD
  • phosphatase binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein domain specific binding Source: RGD
  • protein phosphatase binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-6794361. Interactions of neurexins and neuroligins at synapses.
R-RNO-8849932. SALM protein interactions at the synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 3
Alternative name(s):
PSD-95/SAP90-related protein 1
Synapse-associated protein 102
Short name:
SAP-102
Short name:
SAP102
Gene namesi
Name:Dlg3
Synonyms:Dlgh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi68423. Dlg3.

Subcellular locationi

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: Ensembl
  • basolateral plasma membrane Source: GO_Central
  • bicellular tight junction Source: Ensembl
  • cytoplasm Source: Ensembl
  • dendritic shaft Source: UniProtKB
  • extracellular space Source: Ensembl
  • growth cone Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: GO_Central
  • synapse Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945591 – 849Disks large homolog 3Add BLAST849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphoserineBy similarity1
Modified residuei705PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62936.
PRIDEiQ62936.

PTM databases

iPTMnetiQ62936.
PhosphoSitePlusiQ62936.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002767.
ExpressionAtlasiQ62936. baseline and differential.
GenevisibleiQ62936. RN.

Interactioni

Subunit structurei

Interacts through its PDZ domains with NETO1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3 (By similarity). Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN2. Interacts with LRFN1 and LRFN4. Interacts with FLTP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP2B4P23634-62EBI-349596,EBI-1174437From a different organism.
CRIPTQ9P0215EBI-349596,EBI-946968From a different organism.
DgkiQ810C52EBI-349596,EBI-8523614
DgkzO085604EBI-349596,EBI-8570505
GRIN1Q05586-23EBI-349596,EBI-8286218From a different organism.
GRIN2AQ128795EBI-349596,EBI-7249937From a different organism.
GRIN2BQ132244EBI-349596,EBI-2256942From a different organism.
Grin2bQ009606EBI-349596,EBI-396905
GRIN2CQ149576EBI-349596,EBI-8285963From a different organism.
GRIN2DO153992EBI-349596,EBI-1754030From a different organism.
KCNA1Q094702EBI-349596,EBI-8286599From a different organism.
KCNA4P224594EBI-349596,EBI-631235From a different organism.
Lrfn2Q460M52EBI-349596,EBI-877185

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD
  • PDZ domain binding Source: RGD
  • phosphatase binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein domain specific binding Source: RGD
  • protein phosphatase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi248683. 5 interactors.
IntActiQ62936. 27 interactors.
MINTiMINT-125016.
STRINGi10116.ENSRNOP00000003741.

Structurei

Secondary structure

1849
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi403 – 408Combined sources6
Beta strandi413 – 420Combined sources8
Beta strandi422 – 425Combined sources4
Beta strandi427 – 432Combined sources6
Helixi437 – 441Combined sources5
Beta strandi448 – 453Combined sources6
Helixi463 – 472Combined sources10
Beta strandi476 – 483Combined sources8
Helixi485 – 488Combined sources4
Turni489 – 491Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXTX-ray1.50A/B393-493[»]
ProteinModelPortaliQ62936.
SMRiQ62936.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62936.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 235PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini244 – 330PDZ 2PROSITE-ProRule annotationAdd BLAST87
Domaini404 – 484PDZ 3PROSITE-ProRule annotationAdd BLAST81
Domaini519 – 589SH3PROSITE-ProRule annotationAdd BLAST71
Domaini659 – 834Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST176

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiQ62936.
KOiK12075.
PhylomeDBiQ62936.
TreeFamiTF323171.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. DLG1_PEST_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM01277. MAGUK_N_PEST. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q62936-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG
60 70 80 90 100
YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKNTPKLNG
110 120 130 140 150
SGPSWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI
160 170 180 190 200
VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC
210 220 230 240 250
VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG
260 270 280 290 300
PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN
310 320 330 340 350
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSLHLNDMYA PPDYASTFTA
360 370 380 390 400
LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR
410 420 430 440 450
EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI
460 470 480 490 500
LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE
510 520 530 540 550
QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI
560 570 580 590 600
LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA
610 620 630 640 650
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP
660 670 680 690 700
VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV
710 720 730 740 750
DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH
760 770 780 790 800
CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD
810 820 830 840
KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL
Length:849
Mass (Da):93,539
Last modified:November 1, 1997 - v1
Checksum:i34DA9C46C7BB96DB
GO
Isoform Short (identifier: Q62936-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-640: Missing.

Show »
Length:835
Mass (Da):92,172
Checksum:i95F2227D2F6A7F81
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003151627 – 640Missing in isoform Short. CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50147 mRNA. Translation: AAA93031.1.
U53367 Genomic DNA. Translation: AAB48561.1.
RefSeqiNP_113827.1. NM_031639.1. [Q62936-1]
XP_006257144.1. XM_006257082.3. [Q62936-2]
UniGeneiRn.10238.

Genome annotation databases

EnsembliENSRNOT00000003741; ENSRNOP00000003741; ENSRNOG00000002767. [Q62936-1]
ENSRNOT00000045082; ENSRNOP00000047310; ENSRNOG00000002767. [Q62936-2]
GeneIDi58948.
KEGGirno:58948.
UCSCiRGD:68423. rat. [Q62936-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50147 mRNA. Translation: AAA93031.1.
U53367 Genomic DNA. Translation: AAB48561.1.
RefSeqiNP_113827.1. NM_031639.1. [Q62936-1]
XP_006257144.1. XM_006257082.3. [Q62936-2]
UniGeneiRn.10238.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXTX-ray1.50A/B393-493[»]
ProteinModelPortaliQ62936.
SMRiQ62936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248683. 5 interactors.
IntActiQ62936. 27 interactors.
MINTiMINT-125016.
STRINGi10116.ENSRNOP00000003741.

PTM databases

iPTMnetiQ62936.
PhosphoSitePlusiQ62936.

Proteomic databases

PaxDbiQ62936.
PRIDEiQ62936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003741; ENSRNOP00000003741; ENSRNOG00000002767. [Q62936-1]
ENSRNOT00000045082; ENSRNOP00000047310; ENSRNOG00000002767. [Q62936-2]
GeneIDi58948.
KEGGirno:58948.
UCSCiRGD:68423. rat. [Q62936-1]

Organism-specific databases

CTDi1741.
RGDi68423. Dlg3.

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiQ62936.
KOiK12075.
PhylomeDBiQ62936.
TreeFamiTF323171.

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-6794361. Interactions of neurexins and neuroligins at synapses.
R-RNO-8849932. SALM protein interactions at the synapses.

Miscellaneous databases

EvolutionaryTraceiQ62936.
PROiQ62936.

Gene expression databases

BgeeiENSRNOG00000002767.
ExpressionAtlasiQ62936. baseline and differential.
GenevisibleiQ62936. RN.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. DLG1_PEST_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM01277. MAGUK_N_PEST. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLG3_RAT
AccessioniPrimary (citable) accession number: Q62936
Secondary accession number(s): P70547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.