Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62936

- DLG3_RAT

UniProt

Q62936 - DLG3_RAT

Protein

Disks large homolog 3

Gene

Dlg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.By similarity

    GO - Molecular functioni

    1. ionotropic glutamate receptor binding Source: RGD
    2. PDZ domain binding Source: RGD
    3. phosphatase binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein C-terminus binding Source: UniProtKB
    6. protein domain specific binding Source: RGD
    7. protein phosphatase binding Source: BHF-UCL

    GO - Biological processi

    1. establishment of planar polarity Source: Ensembl
    2. establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
    3. negative regulation of phosphatase activity Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_196422. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large homolog 3
    Alternative name(s):
    PSD-95/SAP90-related protein 1
    Synapse-associated protein 102
    Short name:
    SAP-102
    Short name:
    SAP102
    Gene namesi
    Name:Dlg3
    Synonyms:Dlgh3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi68423. Dlg3.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. dendritic shaft Source: UniProtKB
    4. growth cone Source: UniProtKB
    5. neuronal cell body Source: UniProtKB
    6. postsynaptic density Source: UniProtKB
    7. synapse Source: UniProtKB
    8. tight junction Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 849849Disks large homolog 3PRO_0000094559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ62936.
    PRIDEiQ62936.

    PTM databases

    PhosphoSiteiQ62936.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62936.
    GenevestigatoriQ62936.

    Interactioni

    Subunit structurei

    Interacts through its PDZ domains with NETO1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3 By similarity. Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN2. Interacts with LRFN1 and LRFN4 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATP2B4P23634-62EBI-349596,EBI-1174437From a different organism.
    CRIPTQ9P0215EBI-349596,EBI-946968From a different organism.
    DgkiQ810C52EBI-349596,EBI-8523614
    DgkzO085604EBI-349596,EBI-8570505
    GRIN1Q05586-23EBI-349596,EBI-8286218From a different organism.
    GRIN2AQ128795EBI-349596,EBI-7249937From a different organism.
    GRIN2BQ132244EBI-349596,EBI-2256942From a different organism.
    Grin2bQ009606EBI-349596,EBI-396905
    GRIN2CQ149576EBI-349596,EBI-8285963From a different organism.
    GRIN2DO153992EBI-349596,EBI-1754030From a different organism.
    KCNA1Q094702EBI-349596,EBI-8286599From a different organism.
    KCNA4P224594EBI-349596,EBI-631235From a different organism.
    Lrfn2Q460M52EBI-349596,EBI-877185

    Protein-protein interaction databases

    BioGridi248683. 5 interactions.
    IntActiQ62936. 27 interactions.
    MINTiMINT-125016.

    Structurei

    Secondary structure

    1
    849
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi403 – 4086
    Beta strandi413 – 4208
    Beta strandi422 – 4254
    Beta strandi427 – 4326
    Helixi437 – 4415
    Beta strandi448 – 4536
    Helixi463 – 47210
    Beta strandi476 – 4838
    Helixi485 – 4884
    Turni489 – 4913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JXTX-ray1.50A/B393-493[»]
    ProteinModelPortaliQ62936.
    SMRiQ62936. Positions 144-332, 400-493, 522-849.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ62936.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 23587PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 33087PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 48481PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini519 – 58971SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 834176Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0194.
    GeneTreeiENSGT00660000095130.
    HOGENOMiHOG000232102.
    HOVERGENiHBG107814.
    InParanoidiQ62936.
    KOiK12075.
    OMAiIMEVNLM.
    OrthoDBiEOG79GT6P.
    PhylomeDBiQ62936.
    TreeFamiTF323171.

    Family and domain databases

    Gene3Di2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProiIPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23119. PTHR23119. 1 hit.
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q62936-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG    50
    YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKNTPKLNG 100
    SGPSWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI 150
    VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC 200
    VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG 250
    PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN 300
    NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSLHLNDMYA PPDYASTFTA 350
    LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR 400
    EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI 450
    LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE 500
    QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI 550
    LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA 600
    RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP 650
    VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV 700
    DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH 750
    CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD 800
    KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL 849
    Length:849
    Mass (Da):93,539
    Last modified:November 1, 1997 - v1
    Checksum:i34DA9C46C7BB96DB
    GO
    Isoform Short (identifier: Q62936-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         627-640: Missing.

    Show »
    Length:835
    Mass (Da):92,172
    Checksum:i95F2227D2F6A7F81
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei627 – 64014Missing in isoform Short. CuratedVSP_003151Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50147 mRNA. Translation: AAA93031.1.
    U53367 Genomic DNA. Translation: AAB48561.1.
    RefSeqiNP_113827.1. NM_031639.1. [Q62936-1]
    XP_006257144.1. XM_006257082.1. [Q62936-2]
    UniGeneiRn.10238.

    Genome annotation databases

    EnsembliENSRNOT00000003741; ENSRNOP00000003741; ENSRNOG00000002767. [Q62936-1]
    ENSRNOT00000045082; ENSRNOP00000047310; ENSRNOG00000002767. [Q62936-2]
    GeneIDi58948.
    KEGGirno:58948.
    UCSCiRGD:68423. rat. [Q62936-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50147 mRNA. Translation: AAA93031.1 .
    U53367 Genomic DNA. Translation: AAB48561.1 .
    RefSeqi NP_113827.1. NM_031639.1. [Q62936-1 ]
    XP_006257144.1. XM_006257082.1. [Q62936-2 ]
    UniGenei Rn.10238.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JXT X-ray 1.50 A/B 393-493 [» ]
    ProteinModelPortali Q62936.
    SMRi Q62936. Positions 144-332, 400-493, 522-849.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248683. 5 interactions.
    IntActi Q62936. 27 interactions.
    MINTi MINT-125016.

    PTM databases

    PhosphoSitei Q62936.

    Proteomic databases

    PaxDbi Q62936.
    PRIDEi Q62936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003741 ; ENSRNOP00000003741 ; ENSRNOG00000002767 . [Q62936-1 ]
    ENSRNOT00000045082 ; ENSRNOP00000047310 ; ENSRNOG00000002767 . [Q62936-2 ]
    GeneIDi 58948.
    KEGGi rno:58948.
    UCSCi RGD:68423. rat. [Q62936-1 ]

    Organism-specific databases

    CTDi 1741.
    RGDi 68423. Dlg3.

    Phylogenomic databases

    eggNOGi COG0194.
    GeneTreei ENSGT00660000095130.
    HOGENOMi HOG000232102.
    HOVERGENi HBG107814.
    InParanoidi Q62936.
    KOi K12075.
    OMAi IMEVNLM.
    OrthoDBi EOG79GT6P.
    PhylomeDBi Q62936.
    TreeFami TF323171.

    Enzyme and pathway databases

    Reactomei REACT_196422. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    EvolutionaryTracei Q62936.
    NextBioi 611562.
    PROi Q62936.

    Gene expression databases

    ArrayExpressi Q62936.
    Genevestigatori Q62936.

    Family and domain databases

    Gene3Di 2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProi IPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23119. PTHR23119. 1 hit.
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo."
      Mueller B.M., Kistner U., Kindler S., Chung W.J., Kuhlendahl S., Fenster S.D., Lau L.-F., Veh R.W., Huganir R.L., Gundelfinger E.D., Garner C.C.
      Neuron 17:255-265(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), INTERACTION WITH GRIN2B.
      Tissue: Brain.
    2. "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density."
      Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.
      J. Biol. Chem. 272:11943-11951(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT), INTERACTION WITH DLGAP1; DLGAP2; DLGAP3 AND DLGAP4.
      Tissue: Brain.
    3. "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family."
      Kim J.H., Liao D., Lau L.-F., Huganir R.L.
      Neuron 20:683-691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNGAP1.
    4. "A novel family of adhesion-like molecules that interacts with the NMDA receptor."
      Wang C.Y., Chang K., Petralia R.S., Wang Y.X., Seabold G.K., Wenthold R.J.
      J. Neurosci. 26:2174-2183(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRFN2.
    5. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."
      Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.
      J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FRMPD4.

    Entry informationi

    Entry nameiDLG3_RAT
    AccessioniPrimary (citable) accession number: Q62936
    Secondary accession number(s): P70547
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3