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Protein

von Willebrand factor

Gene

Vwf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).By similarity

GO - Biological processi

  • blood coagulation Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • cellular response to cold Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • liver regeneration Source: RGD
  • platelet activation Source: RGD
  • response to immobilization stress Source: RGD
  • response to L-ascorbic acid Source: RGD
  • response to X-ray Source: RGD

Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Gene namesi
Name:VwfImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621759 Vwf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000065939‹1 – ›430von Willebrand factorAdd BLAST›430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi9 ↔ 12By similarity
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Glycosylationi30O-linked (GalNAc...) threonineBy similarity1
Glycosylationi31O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi47 ↔ 233By similarity
Glycosylationi252O-linked (GalNAc...) threonineBy similarity1
Glycosylationi261O-linked (GalNAc...) serineBy similarity1
Glycosylationi290N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi349N-linked (GlcNAc...) asparagineBy similarity1

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62935
PeptideAtlasiQ62935
PRIDEiQ62935

PTM databases

PhosphoSitePlusiQ62935

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026643

Structurei

3D structure databases

ProteinModelPortaliQ62935
SMRiQ62935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 228VWFA 1; binding site for platelet glycoprotein IbPROSITE-ProRule annotationAdd BLAST177
Domaini273 – ›430VWFA 2PROSITE-ProRule annotationAdd BLAST›158

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
HOGENOMiHOG000169747
PhylomeDBiQ62935

Family and domain databases

Gene3Di3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 1 hit
PfamiView protein in Pfam
PF00092 VWA, 2 hits
PF16164 VWA_N2, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 2 hits

Sequencei

Sequence statusi: Fragment.

Q62935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HCDGVNLTCE ACQEPGGLVV PPTDAPVSST TPYVEDTPEP PLHNFYCSKL
60 70 80 90 100
LDLVFLLDGS YRLSEAEFEV LKAFVVGTME RLHISQKRIR VAVVEYHDGS
110 120 130 140 150
HAYLELRARK RPSELRRIAS QIKYVGSQLA STSEVLKYTL FQIFGKIDRP
160 170 180 190 200
EASRVILLLT ASQEPQRMAR YFTRYLQGFK KKKVILIPVG IGPHANLKQI
210 220 230 240 250
RLIEKQAPEN KAFLLSGVDE LEQRRDEIIN YLCDLAPEAP APSKPPQVAH
260 270 280 290 300
ITVSPGISGV SSPGPKRKSL VLDVVFVLEA SDEVGEANFN KSKEFLEEVI
310 320 330 340 350
QRMDVSPAGT HIAVLQYSYT VNVEYTFKEA QSKEDVLRHV REIRYQGGNR
360 370 380 390 400
TNTGQALQYL SEHSFSPSQG DREQAPNLVY MVTGNPASDE IRRLPGDIQV
410 420 430
VPIGVGSRAN LQELERISRP ITPIFIQDFE
Length:430
Mass (Da):48,139
Last modified:December 7, 2004 - v2
Checksum:i1DCF3148D85DCB69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Sequence conflicti243S → T in AAA96311 (Ref. 1) Curated1
Sequence conflicti243S → T in AAB39496 (Ref. 1) Curated1
Non-terminal residuei430Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50044 mRNA Translation: AAA96311.1
AJ224673 Genomic DNA Translation: CAB37852.1
U81240 mRNA Translation: AAB39496.1
UniGeneiRn.35561

Genome annotation databases

UCSCiRGD:621759 rat

Similar proteinsi

Entry informationi

Entry nameiVWF_RAT
AccessioniPrimary (citable) accession number: Q62935
Secondary accession number(s): Q78E31, Q9Z0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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