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Protein

von Willebrand factor

Gene

Vwf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).By similarity

GO - Biological processi

  • blood coagulation Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • liver regeneration Source: RGD
  • platelet activation Source: RGD
  • response to immobilization stress Source: RGD
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Gene namesi
Name:VwfImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621759. Vwf.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: RGD
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›430›430von Willebrand factorPRO_0000065939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)By similarity
Disulfide bondi9 ↔ 12By similarity
Glycosylationi23 – 231O-linked (GalNAc...)By similarity
Glycosylationi30 – 301O-linked (GalNAc...)By similarity
Glycosylationi31 – 311O-linked (GalNAc...)By similarity
Disulfide bondi47 ↔ 233By similarity
Glycosylationi252 – 2521O-linked (GalNAc...)By similarity
Glycosylationi261 – 2611O-linked (GalNAc...)By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)By similarity
Glycosylationi349 – 3491N-linked (GlcNAc...)By similarity

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62935.
PRIDEiQ62935.

PTM databases

PhosphoSiteiQ62935.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026643.

Structurei

3D structure databases

ProteinModelPortaliQ62935.
SMRiQ62935. Positions 36-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 228177VWFA 1; binding site for platelet glycoprotein IbPROSITE-ProRule annotationAdd
BLAST
Domaini273 – ›430›158VWFA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains at least 2 VWFA domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410XNSK. LUCA.
HOGENOMiHOG000169747.
PhylomeDBiQ62935.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
InterProiIPR032361. VWA_N2.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00092. VWA. 2 hits.
PF16164. VWA_N2. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q62935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HCDGVNLTCE ACQEPGGLVV PPTDAPVSST TPYVEDTPEP PLHNFYCSKL
60 70 80 90 100
LDLVFLLDGS YRLSEAEFEV LKAFVVGTME RLHISQKRIR VAVVEYHDGS
110 120 130 140 150
HAYLELRARK RPSELRRIAS QIKYVGSQLA STSEVLKYTL FQIFGKIDRP
160 170 180 190 200
EASRVILLLT ASQEPQRMAR YFTRYLQGFK KKKVILIPVG IGPHANLKQI
210 220 230 240 250
RLIEKQAPEN KAFLLSGVDE LEQRRDEIIN YLCDLAPEAP APSKPPQVAH
260 270 280 290 300
ITVSPGISGV SSPGPKRKSL VLDVVFVLEA SDEVGEANFN KSKEFLEEVI
310 320 330 340 350
QRMDVSPAGT HIAVLQYSYT VNVEYTFKEA QSKEDVLRHV REIRYQGGNR
360 370 380 390 400
TNTGQALQYL SEHSFSPSQG DREQAPNLVY MVTGNPASDE IRRLPGDIQV
410 420 430
VPIGVGSRAN LQELERISRP ITPIFIQDFE
Length:430
Mass (Da):48,139
Last modified:December 7, 2004 - v2
Checksum:i1DCF3148D85DCB69
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Sequence conflicti243 – 2431S → T in AAA96311 (Ref. 1) Curated
Sequence conflicti243 – 2431S → T in AAB39496 (Ref. 1) Curated
Non-terminal residuei430 – 4301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50044 mRNA. Translation: AAA96311.1.
AJ224673 Genomic DNA. Translation: CAB37852.1.
U81240 mRNA. Translation: AAB39496.1.
UniGeneiRn.35561.

Genome annotation databases

UCSCiRGD:621759. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50044 mRNA. Translation: AAA96311.1.
AJ224673 Genomic DNA. Translation: CAB37852.1.
U81240 mRNA. Translation: AAB39496.1.
UniGeneiRn.35561.

3D structure databases

ProteinModelPortaliQ62935.
SMRiQ62935. Positions 36-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026643.

PTM databases

PhosphoSiteiQ62935.

Proteomic databases

PaxDbiQ62935.
PRIDEiQ62935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621759. rat.

Organism-specific databases

RGDi621759. Vwf.

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410XNSK. LUCA.
HOGENOMiHOG000169747.
PhylomeDBiQ62935.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
InterProiIPR032361. VWA_N2.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00092. VWA. 2 hits.
PF16164. VWA_N2. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Senis Y.A., Slack A., Giles A.R., Maurice D.H.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-372.
    Strain: WistarImported.
    Tissue: Aortic endotheliumImported.
  2. "Molecular evolution of the nuclear von Willebrand factor gene in mammals and the phylogeny of rodents."
    Huchon D., Catzeflis F.M., Douzery E.J.P.
    Mol. Biol. Evol. 16:577-589(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 13-430.
  3. Adams L.D., Werny I., Schwartz S.M.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 131-267.
    Strain: Fischer 344Imported.
    Tissue: AortaImported.
  4. "von Willebrand factor, platelets and endothelial cell interactions."
    Ruggeri Z.M.
    J. Thromb. Haemost. 1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiVWF_RAT
AccessioniPrimary (citable) accession number: Q62935
Secondary accession number(s): Q78E31, Q9Z0P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.