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Protein

Golgi SNAP receptor complex member 1

Gene

Gosr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 1
Alternative name(s):
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Short name:
GOS-28
Short name:
GOS28
Gene namesi
Name:Gosr1
Synonyms:Gs28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi71093. Gosr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 229CytoplasmicSequence analysisAdd BLAST228
Transmembranei230 – 250Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

  • cis-Golgi network Source: RGD
  • cytosol Source: GOC
  • Golgi apparatus Source: MGI
  • Golgi medial cisterna Source: GO_Central
  • Golgi membrane Source: GO_Central
  • integral component of membrane Source: MGI
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002125452 – 250Golgi SNAP receptor complex member 1Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei141PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62931.
PRIDEiQ62931.

PTM databases

iPTMnetiQ62931.
PhosphoSitePlusiQ62931.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003971.
GenevisibleiQ62931. RN.

Interactioni

Subunit structurei

Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2. Interacts with the 34 kDa STX5 isoform.9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Stx5Q0885115EBI-7837133,EBI-2028244
Uso1P4154210EBI-7837133,EBI-4423297

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62931. 7 interactors.
MINTiMINT-4569995.
STRINGi10116.ENSRNOP00000005283.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 30Sequence analysisAdd BLAST22
Coiled coili68 – 95Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the GOSR1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3208. Eukaryota.
ENOG410YI1X. LUCA.
GeneTreeiENSGT00390000008688.
HOGENOMiHOG000207760.
HOVERGENiHBG051764.
InParanoidiQ62931.
KOiK08495.
OMAiINDKMAE.
OrthoDBiEOG091G0W5M.
PhylomeDBiQ62931.
TreeFamiTF105782.

Family and domain databases

InterProiIPR023601. Golgi_SNAP_su1.
[Graphical view]
PANTHERiPTHR21094. PTHR21094. 1 hit.
PIRSFiPIRSF027109. Golgi_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGTSNYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS SARDGGRDRY
60 70 80 90 100
SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTHSAGVPSL
110 120 130 140 150
NAALMHTLQR HRDILQDYTH EFHKTKANFM AIRERENLMG SVRKDIESYK
160 170 180 190 200
SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS
210 220 230 240 250
IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH
Length:250
Mass (Da):28,534
Last modified:November 1, 1996 - v1
Checksum:i0F85EDCE7ADA32E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49099 mRNA. Translation: AAC52597.1.
BC126068 mRNA. Translation: AAI26069.1.
RefSeqiNP_446036.1. NM_053584.2.
UniGeneiRn.8228.

Genome annotation databases

EnsembliENSRNOT00000077063; ENSRNOP00000068434; ENSRNOG00000003971.
GeneIDi94189.
KEGGirno:94189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49099 mRNA. Translation: AAC52597.1.
BC126068 mRNA. Translation: AAI26069.1.
RefSeqiNP_446036.1. NM_053584.2.
UniGeneiRn.8228.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62931. 7 interactors.
MINTiMINT-4569995.
STRINGi10116.ENSRNOP00000005283.

PTM databases

iPTMnetiQ62931.
PhosphoSitePlusiQ62931.

Proteomic databases

PaxDbiQ62931.
PRIDEiQ62931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077063; ENSRNOP00000068434; ENSRNOG00000003971.
GeneIDi94189.
KEGGirno:94189.

Organism-specific databases

CTDi9527.
RGDi71093. Gosr1.

Phylogenomic databases

eggNOGiKOG3208. Eukaryota.
ENOG410YI1X. LUCA.
GeneTreeiENSGT00390000008688.
HOGENOMiHOG000207760.
HOVERGENiHBG051764.
InParanoidiQ62931.
KOiK08495.
OMAiINDKMAE.
OrthoDBiEOG091G0W5M.
PhylomeDBiQ62931.
TreeFamiTF105782.

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiQ62931.

Gene expression databases

BgeeiENSRNOG00000003971.
GenevisibleiQ62931. RN.

Family and domain databases

InterProiIPR023601. Golgi_SNAP_su1.
[Graphical view]
PANTHERiPTHR21094. PTHR21094. 1 hit.
PIRSFiPIRSF027109. Golgi_SNARE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR1_RAT
AccessioniPrimary (citable) accession number: Q62931
Secondary accession number(s): A0JN01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.