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Protein

Interleukin-1 receptor-like 2

Gene

Il1rl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:Il1rl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621782. Il1rl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 338317ExtracellularSequence analysisAdd
BLAST
Transmembranei339 – 35820HelicalSequence analysisAdd
BLAST
Topological domaini359 – 561203CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 561540Interleukin-1 receptor-like 2PRO_0000015447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi44 ↔ 97PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi149 ↔ 199PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi252 ↔ 319PROSITE-ProRule annotation
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62929.
PRIDEiQ62929.

Expressioni

Tissue specificityi

Predominant expression in the lung and epididymis, with lower expression in cerebral cortex and testis. Expression in the brain is non-neuronal and associated with the cerebral vasculature. Not detected in any cell line tested.

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4997325.
STRINGi10116.ENSRNOP00000019880.

Structurei

3D structure databases

ProteinModelPortaliQ62929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11392Ig-like C2-type 1Add
BLAST
Domaini128 – 21588Ig-like C2-type 2Add
BLAST
Domaini225 – 32197Ig-like C2-type 3Add
BLAST
Domaini384 – 542159TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ62929.
KOiK05172.
PhylomeDBiQ62929.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMPPLLFCW VSFVLPLFVA AGNCTDVYMH HEMISEGQPF PFNCTYPPVT
60 70 80 90 100
NGAVNLTWHR TPSKSPISIN RHVRIHQDQS WILFLPLALE DSGIYQCVIK
110 120 130 140 150
DAHSCYRIAI NLTVFRKHWC DSSNEESSIN SSDEYQQWLP IGKSGSLTCH
160 170 180 190 200
LYFPESCVLD SIKWYKGCEE IKVSKKFCPT GTKLLVNNID VEDSGSYACS
210 220 230 240 250
ARLTHLGRIF TVRNYIAVNT KEVGSGGRIP NITYPKNNSI EVQLGSTLIV
260 270 280 290 300
DCNITDTKEN TNLRCWRVNN TLVDDYYNDF KRIQEGIETN LSLRNHILYT
310 320 330 340 350
VNITFLEVKM EDYGHPFTCH AAVSAAYIIL KRPAPDFRAY LIGGLMAFLL
360 370 380 390 400
LAVSILYIYN TFKVDIVLWY RSTFHTAQAP DDEKLYDAYV LYPKYPRESQ
410 420 430 440 450
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR
460 470 480 490 500
LMVLVAPETS SFSFLKNLTE EQIAVYNALV QDGMKVILIE LERVKDYSTM
510 520 530 540 550
PESIQYIRQK HGAIQWDGDF TEQAQCAKTK FWKKVRYHMP PRRYPASPPV
560
QLLGHTPRIP G
Length:561
Mass (Da):64,142
Last modified:November 1, 1996 - v1
Checksum:i4021C297917F0199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49066 mRNA. Translation: AAB53238.1.
RefSeqiNP_598259.1. NM_133575.1.
UniGeneiRn.10235.

Genome annotation databases

GeneIDi171106.
KEGGirno:171106.
UCSCiRGD:621782. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49066 mRNA. Translation: AAB53238.1.
RefSeqiNP_598259.1. NM_133575.1.
UniGeneiRn.10235.

3D structure databases

ProteinModelPortaliQ62929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997325.
STRINGi10116.ENSRNOP00000019880.

Proteomic databases

PaxDbiQ62929.
PRIDEiQ62929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171106.
KEGGirno:171106.
UCSCiRGD:621782. rat.

Organism-specific databases

CTDi8808.
RGDi621782. Il1rl2.

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ62929.
KOiK05172.
PhylomeDBiQ62929.

Miscellaneous databases

NextBioi621798.
PROiQ62929.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)."
    Lovenberg T.W., Crowe P.D., Liu C., Chalmers D.T., Liu X.-J., Liaw C., Clevenger W., Oltersdorf T., De Souza E.B., Maki R.A.
    J. Neuroimmunol. 70:113-122(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiILRL2_RAT
AccessioniPrimary (citable) accession number: Q62929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.