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Q62928

- PE2R2_RAT

UniProt

Q62928 - PE2R2_RAT

Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle By similarity.By similarity

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. cellular response to prostaglandin E stimulus Source: Ensembl
    3. regulation of cell proliferation Source: Ensembl
    4. response to lipopolysaccharide Source: Ensembl
    5. skeletal system development Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Short name:
    PGE receptor EP2 subtype
    Short name:
    PGE2 receptor EP2 subtype
    Alternative name(s):
    Prostanoid EP2 receptor
    Gene namesi
    Name:Ptger2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi620020. Ptger2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Prostaglandin E2 receptor EP2 subtypePRO_0000070056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ62928.

    PTM databases

    PhosphoSiteiQ62928.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62928.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ62928.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 11220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 19922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 26238CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 35734CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 9226Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17725Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22425Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275624.
    GeneTreeiENSGT00690000101953.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiQ62928.
    KOiK04259.
    OMAiRVCTYFA.
    OrthoDBiEOG72VH6G.
    PhylomeDBiQ62928.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62928-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNSFNDSRR VENCESRQYL LSDESPAISS VMFTAGVLGN LIALALLARR    50
    WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL 100
    VALAPESRAC TYFAFTMTFF SLATMLMLFA MALERYLAIG HPYFYRRRVS 150
    RRGGLAVLPA IYGVSLLFCS LPLLNYGEYV QYCPGTWCFI QHGRTAYLQL 200
    YATVLLLLIV AVLGCNISVI LNLIRMQLRS KRSRCGLSGS SLRGPGSRRR 250
    GERTSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMDETS SRKEKWDLRA 300
    LRFLSVNSII DPWVFVILRP PVLRLMRSVL CCRTSLRAPE APGASCSTQQ 350
    TDLCGQL 357
    Length:357
    Mass (Da):39,772
    Last modified:November 1, 1996 - v1
    Checksum:iAAB22A8280AFEFB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48858 mRNA. Translation: AAA97889.1.
    U94708 mRNA. Translation: AAB53325.1.
    AF454964 Genomic DNA. Translation: AAM73855.1.
    RefSeqiNP_112350.1. NM_031088.1.
    UniGeneiRn.10264.

    Genome annotation databases

    EnsembliENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968.
    GeneIDi81752.
    KEGGirno:81752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48858 mRNA. Translation: AAA97889.1 .
    U94708 mRNA. Translation: AAB53325.1 .
    AF454964 Genomic DNA. Translation: AAM73855.1 .
    RefSeqi NP_112350.1. NM_031088.1.
    UniGenei Rn.10264.

    3D structure databases

    ProteinModelPortali Q62928.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q62928.
    ChEMBLi CHEMBL4909.
    GuidetoPHARMACOLOGYi 341.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q62928.

    Proteomic databases

    PRIDEi Q62928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000075209 ; ENSRNOP00000064907 ; ENSRNOG00000050968 .
    GeneIDi 81752.
    KEGGi rno:81752.

    Organism-specific databases

    CTDi 5732.
    RGDi 620020. Ptger2.

    Phylogenomic databases

    eggNOGi NOG275624.
    GeneTreei ENSGT00690000101953.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi Q62928.
    KOi K04259.
    OMAi RVCTYFA.
    OrthoDBi EOG72VH6G.
    PhylomeDBi Q62928.
    TreeFami TF324982.

    Miscellaneous databases

    NextBioi 615510.
    PROi Q62928.

    Gene expression databases

    Genevestigatori Q62928.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype."
      Nemoto K., Pilbeam C.C., Bilak S.R., Raisz L.G.
      Prostaglandins 54:713-725(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes."
      Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D., Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.
      Eur. J. Pharmacol. 340:227-241(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Spleen.
    3. "Constitutive expression of Ptger-ep2 in the pregnant rat uterus."
      Chien E.K., Mendoza J.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiPE2R2_RAT
    AccessioniPrimary (citable) accession number: Q62928
    Secondary accession number(s): Q547S0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3