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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).By similarity

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. cellular response to prostaglandin E stimulus Source: Ensembl
  3. regulation of cell proliferation Source: Ensembl
  4. response to lipopolysaccharide Source: Ensembl
  5. skeletal system development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_246814. G alpha (s) signalling events.
REACT_254225. Prostanoid ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:Ptger2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi620020. Ptger2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 6618CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 9226Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17725Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 19922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22425Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 26238CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini324 – 35734CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Prostaglandin E2 receptor EP2 subtypePRO_0000070056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ62928.

PTM databases

PhosphoSiteiQ62928.

Expressioni

Gene expression databases

GenevestigatoriQ62928.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ62928.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62928.
KOiK04259.
OMAiDPWVFAI.
OrthoDBiEOG72VH6G.
PhylomeDBiQ62928.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62928-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNSFNDSRR VENCESRQYL LSDESPAISS VMFTAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESRAC TYFAFTMTFF SLATMLMLFA MALERYLAIG HPYFYRRRVS
160 170 180 190 200
RRGGLAVLPA IYGVSLLFCS LPLLNYGEYV QYCPGTWCFI QHGRTAYLQL
210 220 230 240 250
YATVLLLLIV AVLGCNISVI LNLIRMQLRS KRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMDETS SRKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFVILRP PVLRLMRSVL CCRTSLRAPE APGASCSTQQ

TDLCGQL
Length:357
Mass (Da):39,772
Last modified:November 1, 1996 - v1
Checksum:iAAB22A8280AFEFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48858 mRNA. Translation: AAA97889.1.
U94708 mRNA. Translation: AAB53325.1.
AF454964 Genomic DNA. Translation: AAM73855.1.
RefSeqiNP_112350.1. NM_031088.1.
UniGeneiRn.10264.

Genome annotation databases

EnsembliENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968.
GeneIDi81752.
KEGGirno:81752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48858 mRNA. Translation: AAA97889.1.
U94708 mRNA. Translation: AAB53325.1.
AF454964 Genomic DNA. Translation: AAM73855.1.
RefSeqiNP_112350.1. NM_031088.1.
UniGeneiRn.10264.

3D structure databases

ProteinModelPortaliQ62928.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ62928.
ChEMBLiCHEMBL4909.
GuidetoPHARMACOLOGYi341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ62928.

Proteomic databases

PRIDEiQ62928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968.
GeneIDi81752.
KEGGirno:81752.

Organism-specific databases

CTDi5732.
RGDi620020. Ptger2.

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62928.
KOiK04259.
OMAiDPWVFAI.
OrthoDBiEOG72VH6G.
PhylomeDBiQ62928.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_246814. G alpha (s) signalling events.
REACT_254225. Prostanoid ligand receptors.

Miscellaneous databases

NextBioi615510.
PROiQ62928.

Gene expression databases

GenevestigatoriQ62928.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype."
    Nemoto K., Pilbeam C.C., Bilak S.R., Raisz L.G.
    Prostaglandins 54:713-725(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes."
    Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D., Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.
    Eur. J. Pharmacol. 340:227-241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spleen.
  3. "Constitutive expression of Ptger-ep2 in the pregnant rat uterus."
    Chien E.K., Mendoza J.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPE2R2_RAT
AccessioniPrimary (citable) accession number: Q62928
Secondary accession number(s): Q547S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.