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Q62928 (PE2R2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP2 subtype

Short name=PGE receptor EP2 subtype
Short name=PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene names
Name:Ptger2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Prostaglandin E2 receptor EP2 subtype
PRO_0000070056

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 6618Cytoplasmic Potential
Transmembrane67 – 9226Helical; Name=2; Potential
Topological domain93 – 11220Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15219Cytoplasmic Potential
Transmembrane153 – 17725Helical; Name=4; Potential
Topological domain178 – 19922Extracellular Potential
Transmembrane200 – 22425Helical; Name=5; Potential
Topological domain225 – 26238Cytoplasmic Potential
Transmembrane263 – 28624Helical; Name=6; Potential
Topological domain287 – 29913Extracellular Potential
Transmembrane300 – 32324Helical; Name=7; Potential
Topological domain324 – 35734Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62928 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAB22A8280AFEFB0

FASTA35739,772
        10         20         30         40         50         60 
MDNSFNDSRR VENCESRQYL LSDESPAISS VMFTAGVLGN LIALALLARR WRGDTGCSAG 

        70         80         90        100        110        120 
SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL VALAPESRAC TYFAFTMTFF 

       130        140        150        160        170        180 
SLATMLMLFA MALERYLAIG HPYFYRRRVS RRGGLAVLPA IYGVSLLFCS LPLLNYGEYV 

       190        200        210        220        230        240 
QYCPGTWCFI QHGRTAYLQL YATVLLLLIV AVLGCNISVI LNLIRMQLRS KRSRCGLSGS 

       250        260        270        280        290        300 
SLRGPGSRRR GERTSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMDETS SRKEKWDLRA 

       310        320        330        340        350 
LRFLSVNSII DPWVFVILRP PVLRLMRSVL CCRTSLRAPE APGASCSTQQ TDLCGQL 

« Hide

References

[1]"Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype."
Nemoto K., Pilbeam C.C., Bilak S.R., Raisz L.G.
Prostaglandins 54:713-725(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes."
Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D., Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.
Eur. J. Pharmacol. 340:227-241(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Spleen.
[3]"Constitutive expression of Ptger-ep2 in the pregnant rat uterus."
Chien E.K., Mendoza J.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48858 mRNA. Translation: AAA97889.1.
U94708 mRNA. Translation: AAB53325.1.
AF454964 Genomic DNA. Translation: AAM73855.1.
RefSeqNP_112350.1. NM_031088.1.
UniGeneRn.10264.

3D structure databases

ProteinModelPortalQ62928.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ62928.
ChEMBLCHEMBL4909.
GuidetoPHARMACOLOGY341.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ62928.

Proteomic databases

PRIDEQ62928.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968.
GeneID81752.
KEGGrno:81752.

Organism-specific databases

CTD5732.
RGD620020. Ptger2.

Phylogenomic databases

eggNOGNOG275624.
GeneTreeENSGT00690000101953.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidQ62928.
KOK04259.
OMARVCTYFA.
OrthoDBEOG72VH6G.
PhylomeDBQ62928.
TreeFamTF324982.

Gene expression databases

GenevestigatorQ62928.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615510.
PROQ62928.

Entry information

Entry namePE2R2_RAT
AccessionPrimary (citable) accession number: Q62928
Secondary accession number(s): Q547S0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries