ID   PNOC_RAT                Reviewed;         181 AA.
AC   Q62923; Q64162;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   21-SEP-2011, entry version 70.
DE   RecName: Full=Prepronociceptin;
DE   Contains:
DE     RecName: Full=Neuropeptide 1;
DE   Contains:
DE     RecName: Full=Nociceptin;
DE     AltName: Full=ORL1 receptor agonist;
DE     AltName: Full=Orphanin FQ;
DE     AltName: Full=PPNOC;
DE   Contains:
DE     RecName: Full=Neuropeptide 2;
DE   Flags: Precursor;
GN   Name=Pnoc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=96323283; PubMed=8710930; DOI=10.1073/pnas.93.16.8677;
RA   Nothacker H.-P., Reinscheid R.K., Mansour A., Henningsen R.A.,
RA   Ardati A., Monsma F.J. Jr., Watson S.J., Civelli O.;
RT   "Primary structure and tissue distribution of the orphanin FQ
RT   precursor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:8677-8682(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96323281; PubMed=8710928; DOI=10.1073/pnas.93.16.8666;
RA   Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G.,
RA   Meunier J.-C., Parmentier M.;
RT   "Structure, tissue distribution, and chromosomal localization of the
RT   prepronociceptin gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 13-181, AND PROTEIN SEQUENCE OF 135-151.
RC   TISSUE=Brain;
RX   MEDLINE=96013745; PubMed=7566152; DOI=10.1038/377532a0;
RA   Meunier J.-C., Mollereau C., Toll L., Suaudeau C., Moisand C.,
RA   Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B.,
RA   Mazarguil H., Vassart G., Parmentier M., Costentin J.;
RT   "Isolation and structure of the endogenous agonist of opioid receptor-
RT   like ORL1 receptor.";
RL   Nature 377:532-535(1995).
CC   -!- FUNCTION: Nociceptin is the ligand of the opioid receptor-like
CC       receptor (OPRL1). It may act as a transmitter in the brain by
CC       modulating nociceptive and locomotor behavior. May be involved in
CC       neuronal differentiation and development.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the spinal cord and
CC       brain, being more abundant in the hypothalamus and striatum. Also
CC       found in small amounts in ovary.
CC   -!- PTM: Specific enzymatic cleavages at paired basic residues
CC       probably yield other active peptides besides nociceptin.
CC   -!- PTM: The N-terminal domain contains 6 conserved cysteines thought
CC       to be involved in disulfide bonding and/or processing.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
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DR   EMBL; U48262; AAC52726.1; -; mRNA.
DR   EMBL; X97375; CAA66043.1; -; mRNA.
DR   EMBL; S79730; AAB35376.1; -; mRNA.
DR   IPI; IPI00210192; -.
DR   PIR; JC6151; JC6151.
DR   RefSeq; NP_037139.1; NM_013007.1.
DR   UniGene; Rn.87935; -.
DR   STRING; Q62923; -.
DR   GeneID; 25516; -.
DR   KEGG; rno:25516; -.
DR   CTD; 5368; -.
DR   RGD; 3362; Pnoc.
DR   eggNOG; roNOG16040; -.
DR   HOVERGEN; HBG008227; -.
DR   InParanoid; Q62923; -.
DR   OrthoDB; EOG44BB3B; -.
DR   NextBio; 606969; -.
DR   ArrayExpress; Q62923; -.
DR   Genevestigator; Q62923; -.
DR   GermOnline; ENSRNOG00000014231; Rattus norvegicus.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD.
DR   GO; GO:0007268; P:synaptic transmission; IDA:RGD.
DR   InterPro; IPR002367; Nociceptin.
DR   InterPro; IPR006024; Opioid_neupept.
DR   PANTHER; PTHR11438; Opioid_neupept; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01031; ORPHNNPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Complete proteome;
KW   Direct protein sequencing; Disulfide bond; Neuropeptide;
KW   Neurotransmitter; Opioid peptide; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL        1     19       Potential.
FT   PROPEP       20     95
FT                                /FTId=PRO_0000008335.
FT   PEPTIDE      98    132       Neuropeptide 1 (Probable).
FT                                /FTId=PRO_0000008336.
FT   PEPTIDE     135    151       Nociceptin.
FT                                /FTId=PRO_0000008337.
FT   PEPTIDE     154    170       Neuropeptide 2 (Probable).
FT                                /FTId=PRO_0000008338.
FT   PROPEP      174    181
FT                                /FTId=PRO_0000008339.
FT   REPEAT      109    114       1.
FT   REPEAT      115    120       2.
FT   REGION      109    120       2 X 6 AA tandem repeats of D-A-E-P-X-A.
SQ   SEQUENCE   181 AA;  20479 MW;  B2E9119CF8702C37 CRC64;
     MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE KVFPRPLWTL
     CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR VRSVVQARDA EPEADAEPVA
     DEADEVEQKQ LQKRFGGFTG ARKSARKLAN QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN
     V
//