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Q62923

- PNOC_RAT

UniProt

Q62923 - PNOC_RAT

Protein

Prepronociceptin

Gene

Pnoc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

    GO - Biological processi

    1. neuropeptide signaling pathway Source: RGD
    2. synaptic transmission Source: RGD

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prepronociceptin
    Cleaved into the following 3 chains:
    Alternative name(s):
    ORL1 receptor agonist
    Orphanin FQ
    PPNOC
    Gene namesi
    Name:Pnoc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi3362. Pnoc.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 9576PRO_0000008335Add
    BLAST
    Peptidei98 – 13235Neuropeptide 1CuratedPRO_0000008336Add
    BLAST
    Peptidei135 – 15117NociceptinPRO_0000008337Add
    BLAST
    Peptidei154 – 17017Neuropeptide 2CuratedPRO_0000008338Add
    BLAST
    Propeptidei174 – 1818PRO_0000008339

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.

    Gene expression databases

    ArrayExpressiQ62923.
    GenevestigatoriQ62923.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati109 – 11461
    Repeati115 – 12062

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni109 – 120122 X 6 AA tandem repeats of D-A-E-P-X-AAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG40726.
    GeneTreeiENSGT00510000049153.
    HOGENOMiHOG000082421.
    HOVERGENiHBG008227.
    InParanoidiQ62923.
    OMAiHLKRMPR.
    OrthoDBiEOG7MH118.
    PhylomeDBiQ62923.

    Family and domain databases

    InterProiIPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62923-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE    50
    KVFPRPLWTL CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR 100
    VRSVVQARDA EPEADAEPVA DEADEVEQKQ LQKRFGGFTG ARKSARKLAN 150
    QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN V 181
    Length:181
    Mass (Da):20,479
    Last modified:November 1, 1997 - v1
    Checksum:iB2E9119CF8702C37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48262 mRNA. Translation: AAC52726.1.
    X97375 mRNA. Translation: CAA66043.1.
    S79730 mRNA. Translation: AAB35376.1.
    PIRiJC6151.
    RefSeqiNP_037139.1. NM_013007.1.
    XP_006252261.1. XM_006252199.1.
    XP_006252262.1. XM_006252200.1.
    UniGeneiRn.87935.

    Genome annotation databases

    EnsembliENSRNOT00000019117; ENSRNOP00000019117; ENSRNOG00000014231.
    GeneIDi25516.
    KEGGirno:25516.
    UCSCiRGD:3362. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48262 mRNA. Translation: AAC52726.1 .
    X97375 mRNA. Translation: CAA66043.1 .
    S79730 mRNA. Translation: AAB35376.1 .
    PIRi JC6151.
    RefSeqi NP_037139.1. NM_013007.1.
    XP_006252261.1. XM_006252199.1.
    XP_006252262.1. XM_006252200.1.
    UniGenei Rn.87935.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019117 ; ENSRNOP00000019117 ; ENSRNOG00000014231 .
    GeneIDi 25516.
    KEGGi rno:25516.
    UCSCi RGD:3362. rat.

    Organism-specific databases

    CTDi 5368.
    RGDi 3362. Pnoc.

    Phylogenomic databases

    eggNOGi NOG40726.
    GeneTreei ENSGT00510000049153.
    HOGENOMi HOG000082421.
    HOVERGENi HBG008227.
    InParanoidi Q62923.
    OMAi HLKRMPR.
    OrthoDBi EOG7MH118.
    PhylomeDBi Q62923.

    Miscellaneous databases

    NextBioi 606969.

    Gene expression databases

    ArrayExpressi Q62923.
    Genevestigatori Q62923.

    Family and domain databases

    InterProi IPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
      Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
      Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-181, PROTEIN SEQUENCE OF 135-151.
      Tissue: Brain.

    Entry informationi

    Entry nameiPNOC_RAT
    AccessioniPrimary (citable) accession number: Q62923
    Secondary accession number(s): Q64162
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3