Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62923

- PNOC_RAT

UniProt

Q62923 - PNOC_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Prepronociceptin

Gene

Pnoc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

GO - Biological processi

  1. neuropeptide signaling pathway Source: RGD
  2. synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter, Opioid peptide

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prepronociceptin
Cleaved into the following 3 chains:
Alternative name(s):
ORL1 receptor agonist
Orphanin FQ
PPNOC
Gene namesi
Name:Pnoc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi3362. Pnoc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 9576PRO_0000008335Add
BLAST
Peptidei98 – 13235Neuropeptide 1CuratedPRO_0000008336Add
BLAST
Peptidei135 – 15117NociceptinPRO_0000008337Add
BLAST
Peptidei154 – 17017Neuropeptide 2CuratedPRO_0000008338Add
BLAST
Propeptidei174 – 1818PRO_0000008339

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.

Gene expression databases

ExpressionAtlasiQ62923. baseline.
GenevestigatoriQ62923.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati109 – 11461
Repeati115 – 12062

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 120122 X 6 AA tandem repeats of D-A-E-P-X-AAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG40726.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiQ62923.
OMAiHLKRMPR.
OrthoDBiEOG7MH118.
PhylomeDBiQ62923.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62923-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE
60 70 80 90 100
KVFPRPLWTL CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR
110 120 130 140 150
VRSVVQARDA EPEADAEPVA DEADEVEQKQ LQKRFGGFTG ARKSARKLAN
160 170 180
QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN V
Length:181
Mass (Da):20,479
Last modified:November 1, 1997 - v1
Checksum:iB2E9119CF8702C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48262 mRNA. Translation: AAC52726.1.
X97375 mRNA. Translation: CAA66043.1.
S79730 mRNA. Translation: AAB35376.1.
PIRiJC6151.
RefSeqiNP_037139.1. NM_013007.1.
XP_006252261.1. XM_006252199.2.
UniGeneiRn.87935.

Genome annotation databases

EnsembliENSRNOT00000019117; ENSRNOP00000019117; ENSRNOG00000014231.
GeneIDi25516.
KEGGirno:25516.
UCSCiRGD:3362. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48262 mRNA. Translation: AAC52726.1 .
X97375 mRNA. Translation: CAA66043.1 .
S79730 mRNA. Translation: AAB35376.1 .
PIRi JC6151.
RefSeqi NP_037139.1. NM_013007.1.
XP_006252261.1. XM_006252199.2.
UniGenei Rn.87935.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019117 ; ENSRNOP00000019117 ; ENSRNOG00000014231 .
GeneIDi 25516.
KEGGi rno:25516.
UCSCi RGD:3362. rat.

Organism-specific databases

CTDi 5368.
RGDi 3362. Pnoc.

Phylogenomic databases

eggNOGi NOG40726.
GeneTreei ENSGT00510000049153.
HOGENOMi HOG000082421.
HOVERGENi HBG008227.
InParanoidi Q62923.
OMAi HLKRMPR.
OrthoDBi EOG7MH118.
PhylomeDBi Q62923.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 606969.

Gene expression databases

ExpressionAtlasi Q62923. baseline.
Genevestigatori Q62923.

Family and domain databases

InterProi IPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
    Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-181, PROTEIN SEQUENCE OF 135-151.
    Tissue: Brain.

Entry informationi

Entry nameiPNOC_RAT
AccessioniPrimary (citable) accession number: Q62923
Secondary accession number(s): Q64162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3