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Q62923 (PNOC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prepronociceptin

Cleaved into the following 3 chains:

  1. Neuropeptide 1
  2. Nociceptin
    Alternative name(s):
    ORL1 receptor agonist
    Orphanin FQ
    PPNOC
  3. Neuropeptide 2
Gene names
Name:Pnoc
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.

Subcellular location

Secreted.

Tissue specificity

Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.

Post-translational modification

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 9576
PRO_0000008335
Peptide98 – 13235Neuropeptide 1 Probable
PRO_0000008336
Peptide135 – 15117Nociceptin Ref.3
PRO_0000008337
Peptide154 – 17017Neuropeptide 2 Probable
PRO_0000008338
Propeptide174 – 1818
PRO_0000008339

Regions

Repeat109 – 11461
Repeat115 – 12062
Region109 – 120122 X 6 AA tandem repeats of D-A-E-P-X-A

Sequences

Sequence LengthMass (Da)Tools
Q62923 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B2E9119CF8702C37

FASTA18120,479
        10         20         30         40         50         60 
MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE KVFPRPLWTL 

        70         80         90        100        110        120 
CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR VRSVVQARDA EPEADAEPVA 

       130        140        150        160        170        180 
DEADEVEQKQ LQKRFGGFTG ARKSARKLAN QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN 


V 

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References

[1]"Primary structure and tissue distribution of the orphanin FQ precursor."
Nothacker H.-P., Reinscheid R.K., Mansour A., Henningsen R.A., Ardati A., Monsma F.J. Jr., Watson S.J., Civelli O.
Proc. Natl. Acad. Sci. U.S.A. 93:8677-8682(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor."
Meunier J.-C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., Costentin J.
Nature 377:532-535(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-181, PROTEIN SEQUENCE OF 135-151.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48262 mRNA. Translation: AAC52726.1.
X97375 mRNA. Translation: CAA66043.1.
S79730 mRNA. Translation: AAB35376.1.
PIRJC6151.
RefSeqNP_037139.1. NM_013007.1.
XP_006252261.1. XM_006252199.1.
XP_006252262.1. XM_006252200.1.
UniGeneRn.87935.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000019117; ENSRNOP00000019117; ENSRNOG00000014231.
GeneID25516.
KEGGrno:25516.
UCSCRGD:3362. rat.

Organism-specific databases

CTD5368.
RGD3362. Pnoc.

Phylogenomic databases

eggNOGNOG40726.
GeneTreeENSGT00510000049153.
HOGENOMHOG000082421.
HOVERGENHBG008227.
InParanoidQ62923.
OMAHLKRMPR.
OrthoDBEOG7MH118.
PhylomeDBQ62923.

Gene expression databases

ArrayExpressQ62923.
GenevestigatorQ62923.

Family and domain databases

InterProIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606969.

Entry information

Entry namePNOC_RAT
AccessionPrimary (citable) accession number: Q62923
Secondary accession number(s): Q64162
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families