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Protein

Prepronociceptin

Gene

Pnoc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.1 Publication
Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.By similarity
Orphanin FQ2: Has potent analgesic activity.By similarity

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: RGD
  • female pregnancy Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • sensory perception Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter, Opioid peptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prepronociceptin
Cleaved into the following 3 chains:
Alternative name(s):
ORL1 receptor agonist
Orphanin FQ
PPNOC
Gene namesi
Name:Pnoc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3362. Pnoc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000833520 – 95Add BLAST76
PeptideiPRO_000000833698 – 132NocistatinCuratedAdd BLAST35
PeptideiPRO_0000008337135 – 151Nociceptin1 PublicationAdd BLAST17
PeptideiPRO_0000008338154 – 170Orphanin FQ2CuratedAdd BLAST17
PropeptideiPRO_0000008339174 – 1818

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ62923.

Expressioni

Tissue specificityi

Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.2 Publications

Gene expression databases

BgeeiENSRNOG00000014231.
GenevisibleiQ62923. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019117.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati109 – 11416
Repeati115 – 12026

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 1202 X 6 AA tandem repeats of D-A-E-P-X-AAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IY0N. Eukaryota.
ENOG4111JDY. LUCA.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiQ62923.
OMAiTPCTKIM.
OrthoDBiEOG091G0WQ7.
PhylomeDBiQ62923.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE
60 70 80 90 100
KVFPRPLWTL CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR
110 120 130 140 150
VRSVVQARDA EPEADAEPVA DEADEVEQKQ LQKRFGGFTG ARKSARKLAN
160 170 180
QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN V
Length:181
Mass (Da):20,479
Last modified:November 1, 1997 - v1
Checksum:iB2E9119CF8702C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48262 mRNA. Translation: AAC52726.1.
X97375 mRNA. Translation: CAA66043.1.
S79730 mRNA. Translation: AAB35376.1.
PIRiJC6151.
RefSeqiNP_037139.1. NM_013007.1.
XP_006252261.1. XM_006252199.3.
UniGeneiRn.87935.

Genome annotation databases

EnsembliENSRNOT00000019117; ENSRNOP00000019117; ENSRNOG00000014231.
GeneIDi25516.
KEGGirno:25516.
UCSCiRGD:3362. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48262 mRNA. Translation: AAC52726.1.
X97375 mRNA. Translation: CAA66043.1.
S79730 mRNA. Translation: AAB35376.1.
PIRiJC6151.
RefSeqiNP_037139.1. NM_013007.1.
XP_006252261.1. XM_006252199.3.
UniGeneiRn.87935.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019117.

Proteomic databases

PaxDbiQ62923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019117; ENSRNOP00000019117; ENSRNOG00000014231.
GeneIDi25516.
KEGGirno:25516.
UCSCiRGD:3362. rat.

Organism-specific databases

CTDi5368.
RGDi3362. Pnoc.

Phylogenomic databases

eggNOGiENOG410IY0N. Eukaryota.
ENOG4111JDY. LUCA.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiQ62923.
OMAiTPCTKIM.
OrthoDBiEOG091G0WQ7.
PhylomeDBiQ62923.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ62923.

Gene expression databases

BgeeiENSRNOG00000014231.
GenevisibleiQ62923. RN.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNOC_RAT
AccessioniPrimary (citable) accession number: Q62923
Secondary accession number(s): Q64162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.