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Q62919

- NELL1_RAT

UniProt

Q62919 - NELL1_RAT

Protein

Protein kinase C-binding protein NELL1

Gene

Nell1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: RGD
    3. identical protein binding Source: RGD
    4. protein kinase C binding Source: RGD

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of cyclin catabolic process Source: UniProtKB
    3. negative regulation of osteoblast proliferation Source: UniProtKB
    4. positive regulation of apoptotic process Source: RGD
    5. positive regulation of bone mineralization Source: UniProtKB
    6. positive regulation of ossification Source: RGD
    7. positive regulation of osteoblast differentiation Source: UniProtKB
    8. protein homotrimerization Source: RGD
    9. regulation of gene expression Source: UniProtKB
    10. regulation of osteoblast differentiation Source: RGD

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL1
    Alternative name(s):
    NEL-like protein 1
    Gene namesi
    Name:Nell1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620998. Nell1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus envelope By similarity. Secreted
    Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. nuclear envelope Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000007665Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi395 ↔ 407PROSITE-ProRule annotation
    Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
    Disulfide bondi418 ↔ 432PROSITE-ProRule annotation
    Disulfide bondi438 ↔ 451PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 460PROSITE-ProRule annotation
    Disulfide bondi462 ↔ 474PROSITE-ProRule annotation
    Disulfide bondi480 ↔ 493PROSITE-ProRule annotation
    Disulfide bondi487 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 529PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi537 ↔ 546PROSITE-ProRule annotation
    Disulfide bondi553 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi560 ↔ 575PROSITE-ProRule annotation
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi577 ↔ 594PROSITE-ProRule annotation
    Disulfide bondi600 ↔ 613PROSITE-ProRule annotation
    Disulfide bondi607 ↔ 622PROSITE-ProRule annotation
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 630PROSITE-ProRule annotation
    Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ62919.
    PRIDEiQ62919.

    PTM databases

    PhosphoSiteiQ62919.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62919.

    Interactioni

    Subunit structurei

    Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization By similarity. Homotrimer. Binds to PKC beta-1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62919.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 227171Laminin G-likeAdd
    BLAST
    Domaini271 – 33262VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 47542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini476 – 51641EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 54731EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini549 – 58739EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini596 – 63136EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini632 – 68756VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini692 – 75059VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    PhylomeDBiQ62919.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMDVILVLW FCVCTARTVL GFGMDPDLQL DIISELDLVN TTLGVTQVAG    50
    LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS 100
    GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH 150
    KVALSVSASH LLLHIDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF 200
    KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM 250
    TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCGNCTCKSG 300
    AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT 350
    KTCRECRGGV LVKITEACPP LNCSAKDHIL PENQCCRVCP GHNFCAEAPK 400
    CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV 450
    CVNLPGLYRC DCVPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH 500
    SCTCQPGYVG NGTICKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI 550
    DECAEGFVEC HNYSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
    ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR 650
    EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ 700
    KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLGCEYTAM FEGECCPRCV 750
    SDPCLAGNIA YDIRKTCLDS FGVSRLSGAV WTMAGSPCTT CKCKNGRVCC 800
    SVDLECIENN 810
    Length:810
    Mass (Da):89,212
    Last modified:May 30, 2000 - v2
    Checksum:i46F09C466AF9AB0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48246 mRNA. Translation: AAC72252.1.
    PIRiT10756.
    RefSeqiNP_112331.1. NM_031069.1.
    UniGeneiRn.10695.

    Genome annotation databases

    GeneIDi81733.
    KEGGirno:81733.
    UCSCiRGD:620998. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48246 mRNA. Translation: AAC72252.1 .
    PIRi T10756.
    RefSeqi NP_112331.1. NM_031069.1.
    UniGenei Rn.10695.

    3D structure databases

    ProteinModelPortali Q62919.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021340.

    PTM databases

    PhosphoSitei Q62919.

    Proteomic databases

    PaxDbi Q62919.
    PRIDEi Q62919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81733.
    KEGGi rno:81733.
    UCSCi RGD:620998. rat.

    Organism-specific databases

    CTDi 4745.
    RGDi 620998. Nell1.

    Phylogenomic databases

    eggNOGi NOG253557.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    PhylomeDBi Q62919.

    Miscellaneous databases

    NextBioi 615404.
    PROi Q62919.

    Gene expression databases

    Genevestigatori Q62919.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2."
      Kuroda S., Oyasu M., Kawakami M., Kanayama N., Tanizawa K., Saito N., Abe T., Matsuhashi S., Ting K.
      Biochem. Biophys. Res. Commun. 265:79-86(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiNELL1_RAT
    AccessioniPrimary (citable) accession number: Q62919
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3