SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62919

- NELL1_RAT

UniProt

Q62919 - NELL1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein kinase C-binding protein NELL1

Gene
Nell1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: RGD
  3. identical protein binding Source: RGD
  4. protein kinase C binding Source: RGD

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of cyclin catabolic process Source: UniProtKB
  3. negative regulation of osteoblast proliferation Source: UniProtKB
  4. positive regulation of apoptotic process Source: RGD
  5. positive regulation of bone mineralization Source: UniProtKB
  6. positive regulation of ossification Source: RGD
  7. positive regulation of osteoblast differentiation Source: UniProtKB
  8. protein homotrimerization Source: RGD
  9. regulation of gene expression Source: UniProtKB
  10. regulation of osteoblast differentiation Source: RGD
Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene namesi
Name:Nell1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620998. Nell1.

Subcellular locationi

Cytoplasm By similarity. Nucleus envelope By similarity. Secreted
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region By similarity.

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. nuclear envelope Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000007665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi224 – 2241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi395 ↔ 407 By similarity
Disulfide bondi401 ↔ 416 By similarity
Disulfide bondi418 ↔ 432 By similarity
Disulfide bondi438 ↔ 451 By similarity
Disulfide bondi445 ↔ 460 By similarity
Disulfide bondi462 ↔ 474 By similarity
Disulfide bondi480 ↔ 493 By similarity
Disulfide bondi487 ↔ 502 By similarity
Disulfide bondi504 ↔ 515 By similarity
Glycosylationi511 – 5111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi519 ↔ 529 By similarity
Disulfide bondi523 ↔ 535 By similarity
Disulfide bondi537 ↔ 546 By similarity
Disulfide bondi553 ↔ 566 By similarity
Disulfide bondi560 ↔ 575 By similarity
Glycosylationi562 – 5621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi577 ↔ 594 By similarity
Disulfide bondi600 ↔ 613 By similarity
Disulfide bondi607 ↔ 622 By similarity
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi624 ↔ 630 By similarity
Glycosylationi708 – 7081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62919.
PRIDEiQ62919.

PTM databases

PhosphoSiteiQ62919.

Expressioni

Gene expression databases

GenevestigatoriQ62919.

Interactioni

Subunit structurei

Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization By similarity. Homotrimer. Binds to PKC beta-1.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021340.

Structurei

3D structure databases

ProteinModelPortaliQ62919.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 227171Laminin G-likeAdd
BLAST
Domaini271 – 33262VWFC 1Add
BLAST
Domaini434 – 47542EGF-like 1; calcium-binding Reviewed predictionAdd
BLAST
Domaini476 – 51641EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini517 – 54731EGF-like 3Add
BLAST
Domaini549 – 58739EGF-like 4; calcium-binding Reviewed predictionAdd
BLAST
Domaini596 – 63136EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini632 – 68756VWFC 2Add
BLAST
Domaini692 – 75059VWFC 3Add
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
PhylomeDBiQ62919.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62919-1 [UniParc]FASTAAdd to Basket

« Hide

MPMDVILVLW FCVCTARTVL GFGMDPDLQL DIISELDLVN TTLGVTQVAG    50
LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS 100
GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH 150
KVALSVSASH LLLHIDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF 200
KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM 250
TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCGNCTCKSG 300
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT 350
KTCRECRGGV LVKITEACPP LNCSAKDHIL PENQCCRVCP GHNFCAEAPK 400
CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV 450
CVNLPGLYRC DCVPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH 500
SCTCQPGYVG NGTICKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI 550
DECAEGFVEC HNYSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR 650
EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ 700
KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLGCEYTAM FEGECCPRCV 750
SDPCLAGNIA YDIRKTCLDS FGVSRLSGAV WTMAGSPCTT CKCKNGRVCC 800
SVDLECIENN 810
Length:810
Mass (Da):89,212
Last modified:May 30, 2000 - v2
Checksum:i46F09C466AF9AB0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48246 mRNA. Translation: AAC72252.1.
PIRiT10756.
RefSeqiNP_112331.1. NM_031069.1.
UniGeneiRn.10695.

Genome annotation databases

GeneIDi81733.
KEGGirno:81733.
UCSCiRGD:620998. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48246 mRNA. Translation: AAC72252.1 .
PIRi T10756.
RefSeqi NP_112331.1. NM_031069.1.
UniGenei Rn.10695.

3D structure databases

ProteinModelPortali Q62919.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021340.

PTM databases

PhosphoSitei Q62919.

Proteomic databases

PaxDbi Q62919.
PRIDEi Q62919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81733.
KEGGi rno:81733.
UCSCi RGD:620998. rat.

Organism-specific databases

CTDi 4745.
RGDi 620998. Nell1.

Phylogenomic databases

eggNOGi NOG253557.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
PhylomeDBi Q62919.

Miscellaneous databases

NextBioi 615404.
PROi Q62919.

Gene expression databases

Genevestigatori Q62919.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2."
    Kuroda S., Oyasu M., Kawakami M., Kanayama N., Tanizawa K., Saito N., Abe T., Matsuhashi S., Ting K.
    Biochem. Biophys. Res. Commun. 265:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNELL1_RAT
AccessioniPrimary (citable) accession number: Q62919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi