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Q62918

- NELL2_RAT

UniProt

Q62918 - NELL2_RAT

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Protein
Protein kinase C-binding protein NELL2
Gene
Nell2, Nel
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: RGD
  3. identical protein binding Source: RGD
  4. protein kinase C binding Source: RGD

GO - Biological processi

  1. protein homotrimerization Source: RGD
  2. regulation of growth Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:Nell2
Synonyms:Nel
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620999. Nell2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. dendrite Source: RGD
  3. extracellular space Source: RGD
  4. membrane Source: RGD
  5. perikaryon Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 816795Protein kinase C-binding protein NELL2
PRO_0000007668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi401 ↔ 413 By similarity
Disulfide bondi407 ↔ 422 By similarity
Disulfide bondi424 ↔ 438 By similarity
Disulfide bondi444 ↔ 457 By similarity
Disulfide bondi451 ↔ 466 By similarity
Disulfide bondi468 ↔ 480 By similarity
Disulfide bondi486 ↔ 499 By similarity
Disulfide bondi493 ↔ 508 By similarity
Disulfide bondi510 ↔ 521 By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi525 ↔ 535 By similarity
Disulfide bondi529 ↔ 541 By similarity
Disulfide bondi543 ↔ 552 By similarity
Disulfide bondi559 ↔ 572 By similarity
Disulfide bondi566 ↔ 581 By similarity
Disulfide bondi583 ↔ 600 By similarity
Disulfide bondi606 ↔ 619 By similarity
Disulfide bondi613 ↔ 628 By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 636 By similarity
Glycosylationi635 – 6351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ62918.

Expressioni

Gene expression databases

GenevestigatoriQ62918.

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1.

Structurei

3D structure databases

ProteinModelPortaliQ62918.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 228174Laminin G-like
Add
BLAST
Domaini272 – 33160VWFC 1
Add
BLAST
Domaini397 – 43943EGF-like 1
Add
BLAST
Domaini440 – 48142EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini482 – 52241EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini523 – 55331EGF-like 4
Add
BLAST
Domaini555 – 60147EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini602 – 63736EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini638 – 69356VWFC 2
Add
BLAST
Domaini698 – 75659VWFC 3
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
HOVERGENiHBG004805.
InParanoidiQ62918.
PhylomeDBiQ62918.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62918-1 [UniParc]FASTAAdd to Basket

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MESRVLLRTF CVILGLEAVW GLGVDPSLQI DVLSELELGE STAGVRQVPG    50
LHNGTKAFLF QDSPRSIKAP IATAERFFQK LRNKHEFTIL VTLKQIHLNS 100
GVILSIHHLD HRYLELESSG HRNEIRLHYR SGTHRPHTEV FPYILADAKW 150
HKLSLAFSAS HLILHIDCNK IYERVVEMPS TDLPLGTTFW LGQRNNAHGY 200
FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILSK 250
TSAKLSRAEQ RMNRLDQCYC ERTCTMKGAT YREFESWTDG CKNCTCLNGT 300
IQCETLVCPA PDCPAKSAPA YVDGKCCKEC KSTCQFQGRS YFEGERSTVF 350
SASGMCVLYE CKDQTMKLVE NAGCPALDCP ESHQIALSHS CCKVCKGYDF 400
CSEKHTCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
CRENTMCVNT PGSFLCICQT GYIRIDDYSC TEHDECLTNQ HNCDENALCF 500
NTVGGHNCVC KPGYTGNGTT CKAFCKDGCK NGGACIAANV CACPQGFTGP 550
SCETDIDECS EGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFAPGGESC 600
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC VHDGKVKHNG 650
QIWVLENDRC SVCSCQTGFV MCQRMVCDCE NPTVDLSCCP ECDPRLSSQC 700
LHQNGETVYN SGDTWAQDCR QCRCLQEEVD CWPLACPEVE CEFSVLPENE 750
CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
NGHVCCSVDP QCLQEL 816
Length:816
Mass (Da):90,953
Last modified:November 1, 1996 - v1
Checksum:iA999F76078060D6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48245 mRNA. Translation: AAC72245.1.
UniGeneiRn.11567.

Genome annotation databases

UCSCiRGD:620999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48245 mRNA. Translation: AAC72245.1 .
UniGenei Rn.11567.

3D structure databases

ProteinModelPortali Q62918.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q62918.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620999. rat.

Organism-specific databases

RGDi 620999. Nell2.

Phylogenomic databases

eggNOGi NOG253557.
HOVERGENi HBG004805.
InParanoidi Q62918.
PhylomeDBi Q62918.

Miscellaneous databases

PROi Q62918.

Gene expression databases

Genevestigatori Q62918.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2."
    Kuroda S., Oyasu M., Kawakami M., Kanayama N., Tanizawa K., Saito N., Abe T., Matsuhashi S., Ting K.
    Biochem. Biophys. Res. Commun. 265:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNELL2_RAT
AccessioniPrimary (citable) accession number: Q62918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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