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Q62918

- NELL2_RAT

UniProt

Q62918 - NELL2_RAT

Protein

Protein kinase C-binding protein NELL2

Gene

Nell2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: RGD
    3. identical protein binding Source: RGD
    4. protein kinase C binding Source: RGD

    GO - Biological processi

    1. protein homotrimerization Source: RGD
    2. regulation of growth Source: RGD

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:Nell2
    Synonyms:Nel
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620999. Nell2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. dendrite Source: RGD
    3. extracellular space Source: RGD
    4. membrane Source: RGD
    5. perikaryon Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 816795Protein kinase C-binding protein NELL2PRO_0000007668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
    Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
    Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
    Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
    Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
    Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
    Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
    Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
    Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ62918.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62918.

    Interactioni

    Subunit structurei

    Homotrimer. Binds to PKC beta-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62918.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 228174Laminin G-likeAdd
    BLAST
    Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    HOVERGENiHBG004805.
    InParanoidiQ62918.
    PhylomeDBiQ62918.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62918-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRVLLRTF CVILGLEAVW GLGVDPSLQI DVLSELELGE STAGVRQVPG    50
    LHNGTKAFLF QDSPRSIKAP IATAERFFQK LRNKHEFTIL VTLKQIHLNS 100
    GVILSIHHLD HRYLELESSG HRNEIRLHYR SGTHRPHTEV FPYILADAKW 150
    HKLSLAFSAS HLILHIDCNK IYERVVEMPS TDLPLGTTFW LGQRNNAHGY 200
    FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILSK 250
    TSAKLSRAEQ RMNRLDQCYC ERTCTMKGAT YREFESWTDG CKNCTCLNGT 300
    IQCETLVCPA PDCPAKSAPA YVDGKCCKEC KSTCQFQGRS YFEGERSTVF 350
    SASGMCVLYE CKDQTMKLVE NAGCPALDCP ESHQIALSHS CCKVCKGYDF 400
    CSEKHTCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
    CRENTMCVNT PGSFLCICQT GYIRIDDYSC TEHDECLTNQ HNCDENALCF 500
    NTVGGHNCVC KPGYTGNGTT CKAFCKDGCK NGGACIAANV CACPQGFTGP 550
    SCETDIDECS EGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFAPGGESC 600
    EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC VHDGKVKHNG 650
    QIWVLENDRC SVCSCQTGFV MCQRMVCDCE NPTVDLSCCP ECDPRLSSQC 700
    LHQNGETVYN SGDTWAQDCR QCRCLQEEVD CWPLACPEVE CEFSVLPENE 750
    CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
    NGHVCCSVDP QCLQEL 816
    Length:816
    Mass (Da):90,953
    Last modified:November 1, 1996 - v1
    Checksum:iA999F76078060D6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48245 mRNA. Translation: AAC72245.1.
    UniGeneiRn.11567.

    Genome annotation databases

    UCSCiRGD:620999. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48245 mRNA. Translation: AAC72245.1 .
    UniGenei Rn.11567.

    3D structure databases

    ProteinModelPortali Q62918.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q62918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620999. rat.

    Organism-specific databases

    RGDi 620999. Nell2.

    Phylogenomic databases

    eggNOGi NOG253557.
    HOVERGENi HBG004805.
    InParanoidi Q62918.
    PhylomeDBi Q62918.

    Miscellaneous databases

    PROi Q62918.

    Gene expression databases

    Genevestigatori Q62918.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2."
      Kuroda S., Oyasu M., Kawakami M., Kanayama N., Tanizawa K., Saito N., Abe T., Matsuhashi S., Ting K.
      Biochem. Biophys. Res. Commun. 265:79-86(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiNELL2_RAT
    AccessioniPrimary (citable) accession number: Q62918
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3