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Q62918 (NELL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene names
Name:Nell2
Synonyms:Nel
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homotrimer. Binds to PKC beta-1.

Subcellular location

Secreted.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 816795Protein kinase C-binding protein NELL2
PRO_0000007668

Regions

Domain55 – 228174Laminin G-like
Domain272 – 33160VWFC 1
Domain397 – 43943EGF-like 1
Domain440 – 48142EGF-like 2; calcium-binding Potential
Domain482 – 52241EGF-like 3; calcium-binding Potential
Domain523 – 55331EGF-like 4
Domain555 – 60147EGF-like 5; calcium-binding Potential
Domain602 – 63736EGF-like 6; calcium-binding Potential
Domain638 – 69356VWFC 2
Domain698 – 75659VWFC 3

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation6351N-linked (GlcNAc...) Potential
Disulfide bond401 ↔ 413 By similarity
Disulfide bond407 ↔ 422 By similarity
Disulfide bond424 ↔ 438 By similarity
Disulfide bond444 ↔ 457 By similarity
Disulfide bond451 ↔ 466 By similarity
Disulfide bond468 ↔ 480 By similarity
Disulfide bond486 ↔ 499 By similarity
Disulfide bond493 ↔ 508 By similarity
Disulfide bond510 ↔ 521 By similarity
Disulfide bond525 ↔ 535 By similarity
Disulfide bond529 ↔ 541 By similarity
Disulfide bond543 ↔ 552 By similarity
Disulfide bond559 ↔ 572 By similarity
Disulfide bond566 ↔ 581 By similarity
Disulfide bond583 ↔ 600 By similarity
Disulfide bond606 ↔ 619 By similarity
Disulfide bond613 ↔ 628 By similarity
Disulfide bond630 ↔ 636 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62918 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A999F76078060D6B

FASTA81690,953
        10         20         30         40         50         60 
MESRVLLRTF CVILGLEAVW GLGVDPSLQI DVLSELELGE STAGVRQVPG LHNGTKAFLF 

        70         80         90        100        110        120 
QDSPRSIKAP IATAERFFQK LRNKHEFTIL VTLKQIHLNS GVILSIHHLD HRYLELESSG 

       130        140        150        160        170        180 
HRNEIRLHYR SGTHRPHTEV FPYILADAKW HKLSLAFSAS HLILHIDCNK IYERVVEMPS 

       190        200        210        220        230        240 
TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK 

       250        260        270        280        290        300 
IMELQDILSK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGAT YREFESWTDG CKNCTCLNGT 

       310        320        330        340        350        360 
IQCETLVCPA PDCPAKSAPA YVDGKCCKEC KSTCQFQGRS YFEGERSTVF SASGMCVLYE 

       370        380        390        400        410        420 
CKDQTMKLVE NAGCPALDCP ESHQIALSHS CCKVCKGYDF CSEKHTCMEN SVCRNLNDRA 

       430        440        450        460        470        480 
VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFLCICQT GYIRIDDYSC 

       490        500        510        520        530        540 
TEHDECLTNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCK NGGACIAANV 

       550        560        570        580        590        600 
CACPQGFTGP SCETDIDECS EGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFAPGGESC 

       610        620        630        640        650        660 
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC VHDGKVKHNG QIWVLENDRC 

       670        680        690        700        710        720 
SVCSCQTGFV MCQRMVCDCE NPTVDLSCCP ECDPRLSSQC LHQNGETVYN SGDTWAQDCR 

       730        740        750        760        770        780 
QCRCLQEEVD CWPLACPEVE CEFSVLPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV 

       790        800        810 
RFTGSSWIKH GTECTLCQCK NGHVCCSVDP QCLQEL 

« Hide

References

[1]"Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2."
Kuroda S., Oyasu M., Kawakami M., Kanayama N., Tanizawa K., Saito N., Abe T., Matsuhashi S., Ting K.
Biochem. Biophys. Res. Commun. 265:79-86(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48245 mRNA. Translation: AAC72245.1.
UniGeneRn.11567.

3D structure databases

ProteinModelPortalQ62918.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ62918.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620999. rat.

Organism-specific databases

RGD620999. Nell2.

Phylogenomic databases

eggNOGNOG253557.
HOVERGENHBG004805.
InParanoidQ62918.
PhylomeDBQ62918.

Gene expression databases

GenevestigatorQ62918.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ62918.

Entry information

Entry nameNELL2_RAT
AccessionPrimary (citable) accession number: Q62918
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families