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Protein

Max dimerization protein 3

Gene

Mxd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Max dimerization protein 3
Short name:
Max dimerizer 3
Alternative name(s):
Max-associated protein 3
Max-interacting transcriptional repressor MAD3
Myx
Gene namesi
Name:Mxd3
Synonyms:Mad3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628624. Mxd3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Max dimerization protein 3PRO_0000253709Add
BLAST

Proteomic databases

PaxDbiQ62912.
PRIDEiQ62912.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021946.

Structurei

3D structure databases

ProteinModelPortaliQ62912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 10953bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 2518Interaction with SIN3A and SIN3BBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPD7. Eukaryota.
ENOG410YHJP. LUCA.
HOGENOMiHOG000247060.
HOVERGENiHBG006314.
InParanoidiQ62912.
KOiK09114.
PhylomeDBiQ62912.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVASNIQV LLQAAEFLER REREAEHGYA SLCPHHSPGT VCRRRKAPLQ
60 70 80 90 100
APGALNSGRH VHNELEKRRR AQLKRCLEQL RQQMPLGVDH TRYTTLSLLR
110 120 130 140 150
GARMHIQKLE EQEQQAQRLK EKLRSRQQSL QQQLEQLQGL LGVRERDRLR
160 170 180 190 200
ADSLDSSGLS SERFDSDQED LEVDVESLVF GTETELLQSF SAGQEHSYSH

STGTWL
Length:206
Mass (Da):23,671
Last modified:November 1, 1996 - v1
Checksum:i7B84C1935FC61667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45986 mRNA. Translation: AAA91185.1.
RefSeqiNP_665716.1. NM_145773.1.
UniGeneiRn.10214.

Genome annotation databases

GeneIDi252915.
KEGGirno:252915.
UCSCiRGD:628624. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45986 mRNA. Translation: AAA91185.1.
RefSeqiNP_665716.1. NM_145773.1.
UniGeneiRn.10214.

3D structure databases

ProteinModelPortaliQ62912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021946.

Proteomic databases

PaxDbiQ62912.
PRIDEiQ62912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252915.
KEGGirno:252915.
UCSCiRGD:628624. rat.

Organism-specific databases

CTDi83463.
RGDi628624. Mxd3.

Phylogenomic databases

eggNOGiENOG410IPD7. Eukaryota.
ENOG410YHJP. LUCA.
HOGENOMiHOG000247060.
HOVERGENiHBG006314.
InParanoidiQ62912.
KOiK09114.
PhylomeDBiQ62912.

Miscellaneous databases

PROiQ62912.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAD3_RAT
AccessioniPrimary (citable) accession number: Q62912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.