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Protein

3-keto-steroid reductase

Gene

Hsd17b7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the reduction of the keto group on the C-3 of sterols.

Catalytic activityi

A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.
17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Pathwayi: zymosterol biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes zymosterol from lanosterol.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Lanosterol 14-alpha demethylase (Cyp51a1)
  2. no protein annotated in this organism
  3. Methylsterol monooxygenase 1 (Msmo1)
  4. Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (Nsdhl)
  5. 3-keto-steroid reductase (Hsd17b7)
  6. no protein annotated in this organism
This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15NADSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • cholesterol biosynthetic process Source: RGD
  • estrogen biosynthetic process Source: UniProtKB-UniPathway
  • hippocampus development Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to prolactin Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00769.
UPA00770; UER00758.

Chemistry databases

SwissLipidsiSLP:000001306.

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-steroid reductase (EC:1.1.1.270)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 7
Short name:
17-beta-HSD 7
Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62)
PRL receptor-associated protein
Short name:
PRAP
Gene namesi
Name:Hsd17b7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2837. Hsd17b7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229ExtracellularSequence analysisAdd BLAST229
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 334CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545881 – 3343-keto-steroid reductaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62904.
PRIDEiQ62904.

PTM databases

iPTMnetiQ62904.
PhosphoSitePlusiQ62904.

Expressioni

Tissue specificityi

Most abundant in ovaries of pregnant animals.

Gene expression databases

GenevisibleiQ62904. RN.

Interactioni

Subunit structurei

Binds to the short form of prolactin receptor.

GO - Molecular functioni

  • prolactin receptor binding Source: RGD

Protein-protein interaction databases

MINTiMINT-4568846.
STRINGi10116.ENSRNOP00000003812.

Structurei

3D structure databases

ProteinModelPortaliQ62904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1478. Eukaryota.
ENOG410XPNE. LUCA.
HOGENOMiHOG000253921.
HOVERGENiHBG058236.
InParanoidiQ62904.
KOiK13373.
OMAiPIMWLIR.
OrthoDBiEOG091G0BR9.
PhylomeDBiQ62904.
TreeFamiTF105433.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVVLITGA SSGIGLALCG RLLAEDDDLH LCLACRNLSK AGAVRDALLA
60 70 80 90 100
SHPSAEVSIV QMDVSNLQSV VRGAEEVKRR FQRLDYLYLN AGIMPNPQLN
110 120 130 140 150
LKAFFCGIFS RNVIHMFSTA EGLLTQNDKI TADGFQEVFE TNLFGHFILI
160 170 180 190 200
RELEPLLCHS DNPSQLIWTS SRNAKKSNFS LEDIQHAKGQ EPYSSSKYAT
210 220 230 240 250
DLLNVALNRN FNQKGLYSSV TCPGVVMTNL TYGILPPFVW TLLLPVIWLL
260 270 280 290 300
RFFAHAFTVT PYNGAEALVW LFHQKPESLN PLTKYLSGTT GLGTNYVKGQ
310 320 330
KMDVDEDTAE KFYKTLLELE KQVRITIQKS DHHS
Length:334
Mass (Da):37,372
Last modified:November 1, 1996 - v1
Checksum:i448B546CE8FCBFAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44803 mRNA. Translation: AAC52623.1.
RefSeqiNP_058931.1. NM_017235.3.
UniGeneiRn.7040.

Genome annotation databases

GeneIDi29540.
KEGGirno:29540.
UCSCiRGD:2837. rat.

Similar proteinsi

Entry informationi

Entry nameiDHB7_RAT
AccessioniPrimary (citable) accession number: Q62904
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families