Reviewed,
UniProtKB/Swiss-Prot Q62904 (DHB7_RAT)
Last modified
November 25, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-keto-steroid reductase EC=1.1.1.270 Alternative name(s): Estradiol 17-beta-dehydrogenase 7 EC=1.1.1.62 17-beta-hydroxysteroid dehydrogenase 7 Short name=17-beta-HSD 7 PRL receptor-associated protein Short name=PRAP | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 334 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Responsible for the reduction of the keto group on the C-3 of sterols. |
| Catalytic activity | 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP(+) = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH. Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H. |
| Pathway | Steroid biosynthesis; estrogen biosynthesis. Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. |
| Subunit structure | Binds to the short form of prolactin receptor. |
| Subcellular location | |
| Tissue specificity | Most abundant in ovaries of pregnant animals. |
| Post-translational modification | Phosphorylated. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Ligand | NAD NADP |
| Molecular function | Oxidoreductase |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-keto-steroid reductase activity Inferred from electronic annotation. Source: EC bindingInferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 334 | 334 | 3-keto-steroid reductase | PRO_0000054588 | |||||
Regions | |||||||||
| Topological domain | 1 – 229 | 229 | Extracellular Potential | ||||||
| Transmembrane | 230 – 250 | 21 | Potential | ||||||
| Topological domain | 251 – 334 | 84 | Cytoplasmic Potential | ||||||
| Nucleotide binding | 8 – 15 | 8 | NAD Potential | ||||||
Sites | |||||||||
| Active site | 193 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 171 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 37 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 178 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 229 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor." Duan W.R., Linzer D.I.H., Gibori G. J. Biol. Chem. 271:15602-15607(1996) [PubMed: 8663045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-18. Strain: Sprague-Dawley. Tissue: Corpus luteum. |
Cross-references
Sequence databases | |
|---|---|
| U44803 mRNA. Translation: AAC52623.1. | |
| RefSeq | NP_058931.1. |
| UniGene | Rn.7040 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000002826. Rattus norvegicus. [Contig view] |
| GeneID | 29540. |
| KEGG | rno:29540. |
Organism-specific databases | |
| RGD | 2837. Hsd17b7. |
Phylogenomic databases | |
| HOVERGEN | Q62904. |
Gene expression databases | |
| ArrayExpress | Q62904. |
| GermOnline | ENSRNOG00000002826. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. |
| PROSITE | PS00061. ADH_SHORT. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 609535. |
Entry information
| Entry name | DHB7_RAT | ||||||||
| Accession | Primary (citable) accession number: Q62904 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


