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Protein

Extracellular matrix protein 1

Gene

Ecm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Biomineralization, Mineral balance, Osteogenesis

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 1
Alternative name(s):
Secretory component p85
Gene namesi
Name:Ecm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620357 Ecm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000004341120 – 562Extracellular matrix protein 1Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei559PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62894
PRIDEiQ62894

PTM databases

iPTMnetiQ62894
PhosphoSitePlusiQ62894

Expressioni

Gene expression databases

BgeeiENSRNOG00000021166
GenevisibleiQ62894 RN

Interactioni

Subunit structurei

Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028740

Structurei

3D structure databases

ProteinModelPortaliQ62894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati172 – 3011Add BLAST130
Repeati305 – 4272Add BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 4272 X approximate repeatsAdd BLAST256

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVN8 Eukaryota
ENOG4111TGN LUCA
GeneTreeiENSGT00390000006215
HOGENOMiHOG000112317
HOVERGENiHBG005561
InParanoidiQ62894
OMAiCCHYPPS
OrthoDBiEOG091G0NAE
PhylomeDBiQ62894
TreeFamiTF330786

Family and domain databases

InterProiView protein in InterPro
IPR008605 ECM1
IPR020858 Serum_albumin-like
PANTHERiPTHR16776 PTHR16776, 1 hit
PfamiView protein in Pfam
PF05782 ECM1, 1 hit
SUPFAMiSSF48552 SSF48552, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTIRSSALI LACLALASAA SEGAFKVSDQ REMKPEHLFQ HLHEVGYAAP
60 70 80 90 100
PSPPQTRRLQ VHHSETSPHD PPLFEEQKEV QPPSSPEDIP VYEEEWLTFL
110 120 130 140 150
NPNVGKVDPA LPQEAIPLQK EQPPPRIPIE QKEIDPPVQH QEEIVQSRQK
160 170 180 190 200
EEKPPTLTGQ HPPEPRTWNP ARHCQQGRRG IWGHRLDGFP PGRPSPDNLK
210 220 230 240 250
QICLPERQHV VYGPWNLPQT GYSHLSRQGE ALNLLETGYS RCCRCRSDTN
260 270 280 290 300
RLDCVKLVWE DAMTQFCEAE FSVKTRPHLC CKQRGEERFS CFQKEAPRPD
310 320 330 340 350
YLLRPCPIHQ TGISSGTQLP FPPGLPTPDN VKNICLLRRF RSVPRNLPAT
360 370 380 390 400
DAIQRQLQAL TRLETEFQRC CRQGHNHTCT WKAWEDTLDG YCDRELAIKT
410 420 430 440 450
HPHSCCHYPP SPARDECFAH LAPYPNYDRD LLTVDLSRVT PNLMDHLCGN
460 470 480 490 500
GRVLSKHKQI PGLIQNMTVR CCELPYPEQA CCGEEEKLAF IEDLCGPRRN
510 520 530 540 550
SWKDPALCCT LSPGDKQANC FNTNYLRNVA LVAGDTGNAT GLGQQGPTGG
560
TNVGPAPGSK EE
Length:562
Mass (Da):63,249
Last modified:December 6, 2005 - v2
Checksum:i41968A0E036EB64A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085879 mRNA Translation: AAH85879.1
U42581 mRNA Translation: AAA84385.1
RefSeqiNP_446334.1, NM_053882.1
UniGeneiRn.97792

Genome annotation databases

EnsembliENSRNOT00000028740; ENSRNOP00000028740; ENSRNOG00000021166
GeneIDi116662
KEGGirno:116662
UCSCiRGD:620357 rat

Similar proteinsi

Entry informationi

Entry nameiECM1_RAT
AccessioniPrimary (citable) accession number: Q62894
Secondary accession number(s): Q5U2S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome