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Protein

Extracellular matrix protein 1

Gene

Ecm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Biomineralization, Mineral balance, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 1
Alternative name(s):
Secretory component p85
Gene namesi
Name:Ecm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620357. Ecm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 562543Extracellular matrix protein 1PRO_0000043411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence analysis
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence analysis
Modified residuei559 – 5591PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62894.
PRIDEiQ62894.

Expressioni

Gene expression databases

GenevisibleiQ62894. RN.

Interactioni

Subunit structurei

Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028740.

Structurei

3D structure databases

ProteinModelPortaliQ62894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 3011301Add
BLAST
Repeati305 – 4271232Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 4272562 X approximate repeatsAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVN8. Eukaryota.
ENOG4111TGN. LUCA.
GeneTreeiENSGT00390000006215.
HOGENOMiHOG000112317.
HOVERGENiHBG005561.
InParanoidiQ62894.
OMAiCCHYPPS.
OrthoDBiEOG7KWSHX.
PhylomeDBiQ62894.
TreeFamiTF330786.

Family and domain databases

InterProiIPR008605. ECM1.
IPR020858. Serum_albumin-like.
[Graphical view]
PfamiPF05782. ECM1. 1 hit.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTIRSSALI LACLALASAA SEGAFKVSDQ REMKPEHLFQ HLHEVGYAAP
60 70 80 90 100
PSPPQTRRLQ VHHSETSPHD PPLFEEQKEV QPPSSPEDIP VYEEEWLTFL
110 120 130 140 150
NPNVGKVDPA LPQEAIPLQK EQPPPRIPIE QKEIDPPVQH QEEIVQSRQK
160 170 180 190 200
EEKPPTLTGQ HPPEPRTWNP ARHCQQGRRG IWGHRLDGFP PGRPSPDNLK
210 220 230 240 250
QICLPERQHV VYGPWNLPQT GYSHLSRQGE ALNLLETGYS RCCRCRSDTN
260 270 280 290 300
RLDCVKLVWE DAMTQFCEAE FSVKTRPHLC CKQRGEERFS CFQKEAPRPD
310 320 330 340 350
YLLRPCPIHQ TGISSGTQLP FPPGLPTPDN VKNICLLRRF RSVPRNLPAT
360 370 380 390 400
DAIQRQLQAL TRLETEFQRC CRQGHNHTCT WKAWEDTLDG YCDRELAIKT
410 420 430 440 450
HPHSCCHYPP SPARDECFAH LAPYPNYDRD LLTVDLSRVT PNLMDHLCGN
460 470 480 490 500
GRVLSKHKQI PGLIQNMTVR CCELPYPEQA CCGEEEKLAF IEDLCGPRRN
510 520 530 540 550
SWKDPALCCT LSPGDKQANC FNTNYLRNVA LVAGDTGNAT GLGQQGPTGG
560
TNVGPAPGSK EE
Length:562
Mass (Da):63,249
Last modified:December 6, 2005 - v2
Checksum:i41968A0E036EB64A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085879 mRNA. Translation: AAH85879.1.
U42581 mRNA. Translation: AAA84385.1.
RefSeqiNP_446334.1. NM_053882.1.
UniGeneiRn.97792.

Genome annotation databases

EnsembliENSRNOT00000028740; ENSRNOP00000028740; ENSRNOG00000021166.
GeneIDi116662.
KEGGirno:116662.
UCSCiRGD:620357. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085879 mRNA. Translation: AAH85879.1.
U42581 mRNA. Translation: AAA84385.1.
RefSeqiNP_446334.1. NM_053882.1.
UniGeneiRn.97792.

3D structure databases

ProteinModelPortaliQ62894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028740.

Proteomic databases

PaxDbiQ62894.
PRIDEiQ62894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028740; ENSRNOP00000028740; ENSRNOG00000021166.
GeneIDi116662.
KEGGirno:116662.
UCSCiRGD:620357. rat.

Organism-specific databases

CTDi1893.
RGDi620357. Ecm1.

Phylogenomic databases

eggNOGiENOG410IVN8. Eukaryota.
ENOG4111TGN. LUCA.
GeneTreeiENSGT00390000006215.
HOGENOMiHOG000112317.
HOVERGENiHBG005561.
InParanoidiQ62894.
OMAiCCHYPPS.
OrthoDBiEOG7KWSHX.
PhylomeDBiQ62894.
TreeFamiTF330786.

Miscellaneous databases

NextBioi619451.
PROiQ62894.

Gene expression databases

GenevisibleiQ62894. RN.

Family and domain databases

InterProiIPR008605. ECM1.
IPR020858. Serum_albumin-like.
[Graphical view]
PfamiPF05782. ECM1. 1 hit.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. Csikos T., Gallinat S., Stoll M., Unger T.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 261-325.
    Strain: Wistar Kyoto.
    Tissue: Heart.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiECM1_RAT
AccessioniPrimary (citable) accession number: Q62894
Secondary accession number(s): Q5U2S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.