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Reviewed, UniProtKB/Swiss-Prot Q62893 (AMHR2_RAT)

Last modified September 2, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anti-Muellerian hormone type-2 receptor
    EC=2.7.11.30
Alternative name(s):
    Anti-Muellerian hormone type II receptor
      Short name=AMH type II receptor
    MIS type II receptor
    MISRII
      Short name=MRII
    C14
Gene names
Name: Amhr2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Developmental stage

Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 557540Anti-Muellerian hormone type-2 receptor

Regions

Topological domain18 – 144127Extracellular Potential
Transmembrane145 – 16521 Potential
Topological domain166 – 557392Cytoplasmic Potential
Domain201 – 511311Protein kinase
Nucleotide binding207 – 2159ATP By similarity

Sites

Active site3311Proton acceptor By similarity
Binding site2281ATP By similarity

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5271C → Y in CAA50731. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q62893-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8EDEE9C0C32EBDD5

FASTA55759,749
        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA 

       250        260        270        280        290        300 
ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 

       310        320        330        340        350        360 
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA 

       370        380        390        400        410        420 
QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS 

       430        440        450        460        470        480 
RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE 

       490        500        510        520        530        540 
LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP 

       550 
QQSSCLLSVQ QGSGSKS 

« Hide

References

[1]"Developmental expression of a candidate Muellerian inhibiting substance type II receptor."
Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.
Endocrinology 137:160-165(1996) [PubMed: 8536608] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct."
Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.
Development 120:189-197(1994) [PubMed: 8119126] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells."
Teixeira J., Kehas D.J., Antun R., Donahoe P.K.
Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999) [PubMed: 10570158] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
Strain: Sprague-Dawley.

Cross-references

Sequence databases

U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
PIRS41627.
RefSeqNP_112260.1.
UniGeneRn.10165

3D structure databases

HSSPHSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000014850. Rattus norvegicus. [Contig view]
GeneID29530.
KEGGrno:29530.

Organism-specific databases

RGD70964. Amhr2.

Phylogenomic databases

HOVERGENQ62893.

Gene expression databases

ArrayExpressQ62893.
GermOnlineENSRNOG00000014850. Rattus norvegicus.

Family and domain databases

InterProIPR017193. Anti-muellerian_hrmn_rcpt_II.
IPR015771. Anti-muellerian_hrmn_rcpt_II_C.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
[Graphical view]
PANTHERPTHR23255:SF4. MIS_II_R. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037392. AMHRII. 1 hit.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. False negative.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Entry information

Entry nameAMHR2_RAT
AccessionPrimary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 2, 2008
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents