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Q62893

- AMHR2_RAT

UniProt

Q62893 - AMHR2_RAT

Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281ATPPROSITE-ProRule annotation
    Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi207 – 2159ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hormone binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. receptor activity Source: UniProtKB
    5. receptor signaling protein serine/threonine kinase activity Source: InterPro
    6. transforming growth factor beta receptor activity, type II Source: MGI
    7. transmembrane receptor protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. sex differentiation Source: UniProtKB
    2. signal transduction Source: UniProtKB
    3. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
    Alternative name(s):
    Anti-Muellerian hormone type II receptor
    Short name:
    AMH type II receptor
    C14
    MIS type II receptor
    Short name:
    MISRII
    Short name:
    MRII
    Gene namesi
    Name:Amhr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi70964. Amhr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 557540Anti-Muellerian hormone type-2 receptorPRO_0000024409Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ62893.
    PRIDEiQ62893.

    PTM databases

    PhosphoSiteiQ62893.

    Expressioni

    Developmental stagei

    Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

    Gene expression databases

    GenevestigatoriQ62893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62893.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 144127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 557392CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini201 – 511311Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3653.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000033920.
    HOVERGENiHBG097461.
    InParanoidiQ62893.
    KOiK04672.
    OMAiCNANYSH.
    OrthoDBiEOG7WHH97.
    PhylomeDBiQ62893.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037392. AMHRII. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP    50
    KGIRCLYSHC CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP 100
    SPSSTLFTCS CGTDFCNANY SHLPPSGNRG APGPQEPQAT PGGPIWMAQL 150
    LLGVFLVLLL SIIILALLQR KACRVQGGSD PEPEPGSGGD CSEELPELAE 200
    LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA ERAVYQLLGL 250
    QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 300
    RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL 350
    GLALVLPGLA QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG 400
    TALQRADVYS LALLLWEILS RCSDLRPDHR PPPFQLAYEA ELGSNPSACE 450
    LWALAVAERK RPNIPSSWSC SATDPRGLRE LLEDCWDADP EARLTAECVQ 500
    QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP QQSSCLLSVQ 550
    QGSGSKS 557
    Length:557
    Mass (Da):59,749
    Last modified:November 1, 1996 - v1
    Checksum:i8EDEE9C0C32EBDD5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti527 – 5271C → Y in CAA50731. (PubMed:8119126)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U42427 mRNA. Translation: AAC52343.1.
    X71916 mRNA. Translation: CAA50731.1.
    AF092445 Genomic DNA. Translation: AAC64138.1.
    PIRiS41627.
    RefSeqiNP_112260.1. NM_030998.1.
    UniGeneiRn.10165.

    Genome annotation databases

    EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
    GeneIDi29530.
    KEGGirno:29530.
    UCSCiRGD:70964. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U42427 mRNA. Translation: AAC52343.1 .
    X71916 mRNA. Translation: CAA50731.1 .
    AF092445 Genomic DNA. Translation: AAC64138.1 .
    PIRi S41627.
    RefSeqi NP_112260.1. NM_030998.1.
    UniGenei Rn.10165.

    3D structure databases

    ProteinModelPortali Q62893.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62893.

    Proteomic databases

    PaxDbi Q62893.
    PRIDEi Q62893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020103 ; ENSRNOP00000020103 ; ENSRNOG00000014850 .
    GeneIDi 29530.
    KEGGi rno:29530.
    UCSCi RGD:70964. rat.

    Organism-specific databases

    CTDi 269.
    RGDi 70964. Amhr2.

    Phylogenomic databases

    eggNOGi KOG3653.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000033920.
    HOVERGENi HBG097461.
    InParanoidi Q62893.
    KOi K04672.
    OMAi CNANYSH.
    OrthoDBi EOG7WHH97.
    PhylomeDBi Q62893.
    TreeFami TF314724.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.

    Miscellaneous databases

    NextBioi 609500.
    PROi Q62893.

    Gene expression databases

    Genevestigatori Q62893.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037392. AMHRII. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression of a candidate Muellerian inhibiting substance type II receptor."
      Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.
      Endocrinology 137:160-165(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct."
      Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.
      Development 120:189-197(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells."
      Teixeira J., Kehas D.J., Antun R., Donahoe P.K.
      Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiAMHR2_RAT
    AccessioniPrimary (citable) accession number: Q62893
    Secondary accession number(s): Q63045, Q9R0A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3