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Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281ATPPROSITE-ProRule annotation
Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2159ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. anti-Mullerian hormone receptor activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. hormone binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. receptor activity Source: UniProtKB
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. transforming growth factor beta receptor activity, type II Source: MGI
  8. transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. negative regulation of anti-Mullerian hormone signaling pathway Source: Ensembl
  2. sex differentiation Source: UniProtKB
  3. signal transduction Source: UniProtKB
  4. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
C14
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:Amhr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi70964. Amhr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 144127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 557392CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 557540Anti-Muellerian hormone type-2 receptorPRO_0000024409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62893.
PRIDEiQ62893.

PTM databases

PhosphoSiteiQ62893.

Expressioni

Developmental stagei

Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

Gene expression databases

GenevestigatoriQ62893.

Structurei

3D structure databases

ProteinModelPortaliQ62893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 511311Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ62893.
KOiK04672.
OMAiCNANYSH.
OrthoDBiEOG7WHH97.
PhylomeDBiQ62893.
TreeFamiTF314724.

Family and domain databases

InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000472. TFB_recept_I/II_C.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP
60 70 80 90 100
KGIRCLYSHC CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP
110 120 130 140 150
SPSSTLFTCS CGTDFCNANY SHLPPSGNRG APGPQEPQAT PGGPIWMAQL
160 170 180 190 200
LLGVFLVLLL SIIILALLQR KACRVQGGSD PEPEPGSGGD CSEELPELAE
210 220 230 240 250
LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA ERAVYQLLGL
260 270 280 290 300
QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL
310 320 330 340 350
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL
360 370 380 390 400
GLALVLPGLA QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG
410 420 430 440 450
TALQRADVYS LALLLWEILS RCSDLRPDHR PPPFQLAYEA ELGSNPSACE
460 470 480 490 500
LWALAVAERK RPNIPSSWSC SATDPRGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP QQSSCLLSVQ

QGSGSKS
Length:557
Mass (Da):59,749
Last modified:October 31, 1996 - v1
Checksum:i8EDEE9C0C32EBDD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti527 – 5271C → Y in CAA50731 (PubMed:8119126).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
PIRiS41627.
RefSeqiNP_112260.1. NM_030998.1.
UniGeneiRn.10165.

Genome annotation databases

EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
GeneIDi29530.
KEGGirno:29530.
UCSCiRGD:70964. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
PIRiS41627.
RefSeqiNP_112260.1. NM_030998.1.
UniGeneiRn.10165.

3D structure databases

ProteinModelPortaliQ62893.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ62893.

Proteomic databases

PaxDbiQ62893.
PRIDEiQ62893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
GeneIDi29530.
KEGGirno:29530.
UCSCiRGD:70964. rat.

Organism-specific databases

CTDi269.
RGDi70964. Amhr2.

Phylogenomic databases

eggNOGiKOG3653.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ62893.
KOiK04672.
OMAiCNANYSH.
OrthoDBiEOG7WHH97.
PhylomeDBiQ62893.
TreeFamiTF314724.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Miscellaneous databases

NextBioi609500.
PROiQ62893.

Gene expression databases

GenevestigatoriQ62893.

Family and domain databases

InterProiIPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000472. TFB_recept_I/II_C.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Developmental expression of a candidate Muellerian inhibiting substance type II receptor."
    Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.
    Endocrinology 137:160-165(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct."
    Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.
    Development 120:189-197(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells."
    Teixeira J., Kehas D.J., Antun R., Donahoe P.K.
    Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiAMHR2_RAT
AccessioniPrimary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.