Anti-Muellerian hormone type-2 receptor precursor

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Reviewed, UniProtKB/Swiss-Prot Q62893 (AMHR2_RAT)

Last modified February 9, 2010. Version 89. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Anti-Muellerian hormone type-2 receptor
    EC=2.7.11.30
Alternative name(s):
    Anti-Muellerian hormone type II receptor
      Short name=AMH type II receptor
    MIS type II receptor
      Short name=MISRII
      Short name=MRII
    C14

Gene names

Name:

Amhr2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Developmental stage	Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

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Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro sex differentiation Inferred from sequence or structural similarity. Source: UniProtKB transforming growth factor beta receptor signaling pathway Inferred from direct assay. Source: MGI
Cellular component	integral to plasma membrane Inferred from direct assay. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hormone binding Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity, type II Inferred from direct assay. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

Potential

Chain

18 – 557

540

Anti-Muellerian hormone type-2 receptor

PRO_0000024409

Regions

Topological domain

18 – 144

127

Extracellular Potential

Transmembrane

145 – 165

Potential

Topological domain

166 – 557

392

Cytoplasmic Potential

Domain

201 – 511

311

Protein kinase

Nucleotide binding

207 – 215

ATP By similarity

Sites

Active site

331

Proton acceptor By similarity

Binding site

228

ATP By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

119

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

527

C → Y in CAA50731. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q62893-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8EDEE9C0C32EBDD5
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FASTA

557

59,749

        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA 

       250        260        270        280        290        300 
ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 

       310        320        330        340        350        360 
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA 

       370        380        390        400        410        420 
QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS 

       430        440        450        460        470        480 
RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE 

       490        500        510        520        530        540 
LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP 

       550 
QQSSCLLSVQ QGSGSKS

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References

[1]	"Developmental expression of a candidate Muellerian inhibiting substance type II receptor." Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K. Endocrinology 137:160-165(1996) [PubMed: 8536608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct." Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J. Development 120:189-197(1994) [PubMed: 8119126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells." Teixeira J., Kehas D.J., Antun R., Donahoe P.K. Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999) [PubMed: 10570158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	U42427 mRNA. Translation: AAC52343.1. X71916 mRNA. Translation: CAA50731.1. AF092445 Genomic DNA. Translation: AAC64138.1.
IPI	IPI00209322.
PIR	S41627.
RefSeq	NP_112260.1.
UniGene	Rn.10165
3D structure databases
SMR	Q62893. Positions 21-125, 199-506.
ModBase	Search...
Protein-protein interaction databases
STRING	Q62893.
Proteomic databases
PRIDE	Q62893.
Genome annotation databases
Ensembl	ENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850; Rattus norvegicus. [Genome view]
GeneID	29530.
KEGG	rno:29530.
UCSC	NM_030998. rat.
Organism-specific databases
CTD	29530.
RGD	70964. Amhr2.
Phylogenomic databases
eggNOG	roNOG15485.
HOVERGEN	Q62893.
InParanoid	Q62893.
Enzyme and pathway databases
BRENDA	2.7.10.2. 248. 2.7.11.30. 248.
Gene expression databases
ArrayExpress	Q62893.
Genevestigator	Q62893.
GermOnline	ENSRNOG00000014850. Rattus norvegicus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR017193. Anti-muellerian_hrmn_rcpt_II. IPR015771. Anti-muellerian_hrmn_rcpt_II_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. [Graphical view]
PANTHER	PTHR23255:SF4. MIS_II_R. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF037392. AMHRII. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	609500.

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Entry information

Entry name

AMHR2_RAT

Accession

Primary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents