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Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 215ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • female gonad development Source: RGD
  • male gonad development Source: RGD
  • negative regulation of anti-Mullerian hormone signaling pathway Source: Ensembl
  • sex differentiation Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: MGI

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 5301
ReactomeiR-RNO-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
C14
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:Amhr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi70964 Amhr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 144ExtracellularSequence analysisAdd BLAST127
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 557CytoplasmicSequence analysisAdd BLAST392

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002440918 – 557Anti-Muellerian hormone type-2 receptorAdd BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 79By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 109By similarity
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62893
PRIDEiQ62893

PTM databases

PhosphoSitePlusiQ62893

Expressioni

Developmental stagei

Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

Gene expression databases

BgeeiENSRNOG00000014850
ExpressionAtlasiQ62893 baseline and differential
GenevisibleiQ62893 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020103

Structurei

3D structure databases

ProteinModelPortaliQ62893
SMRiQ62893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 511Protein kinasePROSITE-ProRule annotationAdd BLAST311

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000033920
HOVERGENiHBG097461
InParanoidiQ62893
KOiK04672
OMAiCCFGIWN
OrthoDBiEOG091G05X7
PhylomeDBiQ62893
TreeFamiTF314724

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR015771 Anti-muellerian_hrmn_rcpt_II
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037392 AMHRII, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP
60 70 80 90 100
KGIRCLYSHC CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP
110 120 130 140 150
SPSSTLFTCS CGTDFCNANY SHLPPSGNRG APGPQEPQAT PGGPIWMAQL
160 170 180 190 200
LLGVFLVLLL SIIILALLQR KACRVQGGSD PEPEPGSGGD CSEELPELAE
210 220 230 240 250
LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA ERAVYQLLGL
260 270 280 290 300
QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL
310 320 330 340 350
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL
360 370 380 390 400
GLALVLPGLA QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG
410 420 430 440 450
TALQRADVYS LALLLWEILS RCSDLRPDHR PPPFQLAYEA ELGSNPSACE
460 470 480 490 500
LWALAVAERK RPNIPSSWSC SATDPRGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP QQSSCLLSVQ

QGSGSKS
Length:557
Mass (Da):59,749
Last modified:November 1, 1996 - v1
Checksum:i8EDEE9C0C32EBDD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527C → Y in CAA50731 (PubMed:8119126).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42427 mRNA Translation: AAC52343.1
X71916 mRNA Translation: CAA50731.1
AF092445 Genomic DNA Translation: AAC64138.1
PIRiS41627
RefSeqiNP_112260.1, NM_030998.1
UniGeneiRn.10165

Genome annotation databases

EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850
GeneIDi29530
KEGGirno:29530
UCSCiRGD:70964 rat

Similar proteinsi

Entry informationi

Entry nameiAMHR2_RAT
AccessioniPrimary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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