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Q62893 (AMHR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anti-Muellerian hormone type-2 receptor
EC=2.7.11.30
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name=AMH type II receptor
C14
MIS type II receptor
Short name=MISRII
Short name=MRII
Gene names
Name:Amhr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Developmental stage

Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 557540Anti-Muellerian hormone type-2 receptor
PRO_0000024409

Regions

Topological domain18 – 144127Extracellular Potential
Transmembrane145 – 16521Helical; Potential
Topological domain166 – 557392Cytoplasmic Potential
Domain201 – 511311Protein kinase
Nucleotide binding207 – 2159ATP By similarity

Sites

Active site3311Proton acceptor By similarity
Binding site2281ATP By similarity

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5271C → Y in CAA50731. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q62893 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8EDEE9C0C32EBDD5

FASTA55759,749
        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA 

       250        260        270        280        290        300 
ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 

       310        320        330        340        350        360 
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA 

       370        380        390        400        410        420 
QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS 

       430        440        450        460        470        480 
RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE 

       490        500        510        520        530        540 
LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP 

       550 
QQSSCLLSVQ QGSGSKS

« Hide

References

[1]"Developmental expression of a candidate Muellerian inhibiting substance type II receptor."
Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.
Endocrinology 137:160-165(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct."
Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.
Development 120:189-197(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells."
Teixeira J., Kehas D.J., Antun R., Donahoe P.K.
Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
IPIIPI00209322.
PIRS41627.
RefSeqNP_112260.1. NM_030998.1.
UniGeneRn.10165.

3D structure databases

ProteinModelPortalQ62893.
ModBaseSearch...

PTM databases

PhosphoSiteQ62893.

Proteomic databases

PaxDbQ62893.
PRIDEQ62893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
GeneID29530.
KEGGrno:29530.
UCSCRGD:70964. rat.

Organism-specific databases

CTD269.
RGD70964. Amhr2.

Phylogenomic databases

eggNOGKOG3653.
GeneTreeENSGT00560000076906.
HOGENOMHOG000033920.
HOVERGENHBG097461.
InParanoidQ62893.
KOK04672.
OrthoDBEOG4SQWWM.

Enzyme and pathway databases

BRENDA2.7.10.2. 5301.

Gene expression databases

GenevestigatorQ62893.
GermOnlineENSRNOG00000014850. Rattus norvegicus.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
[Graphical view]
PANTHERPTHR23255:SF4. PTHR23255:SF4. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037392. AMHRII. 1 hit.
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio609500.

Entry information

Entry nameAMHR2_RAT
AccessionPrimary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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