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Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 215ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • female gonad development Source: RGD
  • male gonad development Source: RGD
  • negative regulation of anti-Mullerian hormone signaling pathway Source: Ensembl
  • sex differentiation Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
C14
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:Amhr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi70964. Amhr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 144ExtracellularSequence analysisAdd BLAST127
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 557CytoplasmicSequence analysisAdd BLAST392

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002440918 – 557Anti-Muellerian hormone type-2 receptorAdd BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 79By similarity
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 109By similarity
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62893.
PRIDEiQ62893.

PTM databases

PhosphoSitePlusiQ62893.

Expressioni

Developmental stagei

Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads.

Gene expression databases

BgeeiENSRNOG00000014850.
ExpressionAtlasiQ62893. baseline and differential.
GenevisibleiQ62893. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020103.

Structurei

3D structure databases

ProteinModelPortaliQ62893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 511Protein kinasePROSITE-ProRule annotationAdd BLAST311

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00860000133897.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ62893.
KOiK04672.
OMAiCNANYSH.
OrthoDBiEOG091G05X7.
PhylomeDBiQ62893.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP
60 70 80 90 100
KGIRCLYSHC CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP
110 120 130 140 150
SPSSTLFTCS CGTDFCNANY SHLPPSGNRG APGPQEPQAT PGGPIWMAQL
160 170 180 190 200
LLGVFLVLLL SIIILALLQR KACRVQGGSD PEPEPGSGGD CSEELPELAE
210 220 230 240 250
LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA ERAVYQLLGL
260 270 280 290 300
QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL
310 320 330 340 350
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL
360 370 380 390 400
GLALVLPGLA QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG
410 420 430 440 450
TALQRADVYS LALLLWEILS RCSDLRPDHR PPPFQLAYEA ELGSNPSACE
460 470 480 490 500
LWALAVAERK RPNIPSSWSC SATDPRGLRE LLEDCWDADP EARLTAECVQ
510 520 530 540 550
QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP QQSSCLLSVQ

QGSGSKS
Length:557
Mass (Da):59,749
Last modified:November 1, 1996 - v1
Checksum:i8EDEE9C0C32EBDD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527C → Y in CAA50731 (PubMed:8119126).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
PIRiS41627.
RefSeqiNP_112260.1. NM_030998.1.
UniGeneiRn.10165.

Genome annotation databases

EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
GeneIDi29530.
KEGGirno:29530.
UCSCiRGD:70964. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42427 mRNA. Translation: AAC52343.1.
X71916 mRNA. Translation: CAA50731.1.
AF092445 Genomic DNA. Translation: AAC64138.1.
PIRiS41627.
RefSeqiNP_112260.1. NM_030998.1.
UniGeneiRn.10165.

3D structure databases

ProteinModelPortaliQ62893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020103.

PTM databases

PhosphoSitePlusiQ62893.

Proteomic databases

PaxDbiQ62893.
PRIDEiQ62893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020103; ENSRNOP00000020103; ENSRNOG00000014850.
GeneIDi29530.
KEGGirno:29530.
UCSCiRGD:70964. rat.

Organism-specific databases

CTDi269.
RGDi70964. Amhr2.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00860000133897.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ62893.
KOiK04672.
OMAiCNANYSH.
OrthoDBiEOG091G05X7.
PhylomeDBiQ62893.
TreeFamiTF314724.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Miscellaneous databases

PROiQ62893.

Gene expression databases

BgeeiENSRNOG00000014850.
ExpressionAtlasiQ62893. baseline and differential.
GenevisibleiQ62893. RN.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMHR2_RAT
AccessioniPrimary (citable) accession number: Q62893
Secondary accession number(s): Q63045, Q9R0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.