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Protein
Submitted name:

Vascular protein tyrosine phosphatase 1

Gene

Ptprj

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Vascular protein tyrosine phosphatase 1Imported
Gene namesi
Name:PtprjImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3454. Ptprj.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei854 – 87522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 12161181Sequence analysisPRO_5004265609Add
BLAST

Proteomic databases

PaxDbiQ62884.
PRIDEiQ62884.

Interactioni

Protein-protein interaction databases

IntActiQ62884. 4 interactions.
MINTiMINT-7026705.
STRINGi10116.ENSRNOP00000044688.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I36X-ray1.84A875-1216[»]
ProteinModelPortaliQ62884.
SMRiQ62884. Positions 898-1190.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62884.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12486Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini150 – 24798Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini248 – 33588Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini336 – 42186Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini422 – 50887Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini600 – 69697Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini920 – 1177258Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1095 – 116874TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000232054.
HOVERGENiHBG053761.
PhylomeDBiQ62884.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 6 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPAARETRT PPRSPGLRWA LLPLLLLLRQ GQVVCTGAAP SPVFDVEAVT
60 70 80 90 100
SPTSVVLTWK HNDSATSEYK INEGNTLRYT VKNQTSFNIT GLSPATSYKF
110 120 130 140 150
SITLGTVNET SGKPTYKNIT TEPWPVSDLQ VAYIGVTQAL LAWSNANGTA
160 170 180 190 200
SYRMQIVELT TNSSGGISDL KPGTHKSLAV QGSNETQHDL WVTEGVSDPP
210 220 230 240 250
SARDPSLTEV LLTELKPDTQ YKVTIYSQAA DGTEGQPGNK VFKTNPIQVS
260 270 280 290 300
DIRAVNISDS NMTLTWKSNN NESHASFTYK IYVAGGSDSI NETVNETQAV
310 320 330 340 350
IRGLSSSTLY NITVLPFLGQ TAGIPGFLQV YTSPRPVSDF RVTNVSLREI
360 370 380 390 400
GLAWRSNDSE SFEIFITQEG SEKRWNASTG DLSYIVVNLK PGTSYQFEIF
410 420 430 440 450
PRGPNGTEGP SQTVVGRTDC SAVTDIRVVS VSTTEIQLEW QNTDSASGYT
460 470 480 490 500
YHLVLESENG SIKTNSSQKW ITVGGLTPGT LYNVTIFPEV DQMEGNSSSI
510 520 530 540 550
TQYTRPSNVS YIEVNTNTTV GAIQWKNLDA ASASYSYSVL ILKAGDGSNV
560 570 580 590 600
TSRVRDIPSV TIPGLIPGVS SEVKIFTKIR NTEVGNEVPG QKLFCMEPAQ
610 620 630 640 650
VDSLHCEVVP KEPALVLKWA CPPGMNSGFE LGVRSDAWDN MTHLENCTLD
660 670 680 690 700
NDTECRTEVT YLNFSTSYNI SIATLSCGKM ALPTQSTCTT GITDPPPPDG
710 720 730 740 750
SPNITSVSHN SVKVKFSGFE ASHGPIKAYA VLLTTGEAGQ PSTDVLKYTY
760 770 780 790 800
EDFKKGASDT YVTYLIRIEE KGQSQGLSEA LNYEIDVGNQ STTLGYYNGR
810 820 830 840 850
LEPLGSYRAC VAGFTNITYN LQNDGLINGD ESYVSFSPYS EAVSLPQDPG
860 870 880 890 900
VICGAVFGCI FGALAIVAVG GFIFWRKKRK DAKNNEVSFS QIKPKKSKLI
910 920 930 940 950
RVENFEAYFK KQQADSNCGF AEEYEDLKLI GISLPKYAAE IAENRGKNRY
960 970 980 990 1000
NNVLPYDISR VKLSVQTHST DDYINANYMP GYHSKKDFIA TQGPLPNTLK
1010 1020 1030 1040 1050
DFWRMVWEKN VYAIVMLTKC VEQGRTKCEE YWPSKQAQDY GDITVAMTSE
1060 1070 1080 1090 1100
VVLPEWTIRD FVVKNMQSSE SHPLRQFHFT SWPDHGVPDT TDLLINFRYL
1110 1120 1130 1140 1150
VRDYMKQIPP ESPILVHCSA GVGRTGTFIA IDRLIYQIEN ENTVDVYGIV
1160 1170 1180 1190 1200
YDLRMHRPLM VQTEDQYVFL NQCVLDIIRA QKDSKVDLIY QNTTAMTIYE
1210
NLERVSMFGK ANGYIA
Length:1,216
Mass (Da):134,276
Last modified:November 1, 1996 - v1
Checksum:i4D6193B108E53591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40790 mRNA. Translation: AAB53195.1.
UniGeneiRn.10278.

Genome annotation databases

UCSCiRGD:3454. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40790 mRNA. Translation: AAB53195.1.
UniGeneiRn.10278.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I36X-ray1.84A875-1216[»]
ProteinModelPortaliQ62884.
SMRiQ62884. Positions 898-1190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62884. 4 interactions.
MINTiMINT-7026705.
STRINGi10116.ENSRNOP00000044688.

Proteomic databases

PaxDbiQ62884.
PRIDEiQ62884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3454. rat.

Organism-specific databases

RGDi3454. Ptprj.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000232054.
HOVERGENiHBG053761.
PhylomeDBiQ62884.

Miscellaneous databases

EvolutionaryTraceiQ62884.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 6 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells."
    Borges L.G., Seifert R.A., Grant F.J., Hart C.E., Disteche C.M., Edelhoff S., Solca F.F., Lieberman M.A., Lindner V., Fischer E.H., Lok S., Bowen-Pope D.F.
    Circ. Res. 79:570-580(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wistar KyotoImported.
    Tissue: AortaImported.
  2. "To be Published."
    Nascimento A.S., Matozo H.C., Palmieri D., Iuliano R., Santos M.A.M., Fusco A., Polikarpov I.
    Submitted (JUN-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 875-1216.

Entry informationi

Entry nameiQ62884_RAT
AccessioniPrimary (citable) accession number: Q62884
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.