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Protein

Transcription initiation factor TFIID subunit 9B

Gene

Taf9b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for cell viability. TAF9 and TAF9L are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).By similarity

GO - Biological processi

  • DNA-templated transcription, initiation Source: InterPro
  • programmed cell death Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 9B
Alternative name(s):
Neuronal cell death-related gene in neuron 7
Short name:
DN-7
Transcription initiation factor TFIID subunit 9-like
Transcription-associated factor TAFII31L
Gene namesi
Name:Taf9b
Synonyms:Dn7, Taf9l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621116. Taf9b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Transcription initiation factor TFIID subunit 9BPRO_0000118893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei159 – 1591PhosphothreonineBy similarity
Modified residuei174 – 1741PhosphothreonineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62880.
PRIDEiQ62880.

PTM databases

iPTMnetiQ62880.
PhosphoSiteiQ62880.

Expressioni

Inductioni

By apoptotic signals in PC12 cells.1 Publication

Gene expression databases

GenevisibleiQ62880. RN.

Interactioni

Subunit structurei

Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003335.

Structurei

3D structure databases

ProteinModelPortaliQ62880.
SMRiQ62880. Positions 13-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 25614Poly-AspAdd
BLAST

Sequence similaritiesi

Belongs to the TAF9 family.Curated

Phylogenomic databases

eggNOGiKOG3334. Eukaryota.
COG5094. LUCA.
GeneTreeiENSGT00390000001626.
HOGENOMiHOG000231730.
HOVERGENiHBG002304.
InParanoidiQ62880.
KOiK03133.
OMAiNMANESN.
OrthoDBiEOG7HF1KM.
PhylomeDBiQ62880.
TreeFamiTF351417.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view]
PfamiPF02291. TFIID-31kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSKMAPLK NAPRDALVMA QILKDMGITD YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN
110 120 130 140 150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLVKKGPNQG RLVPRLSVGA
160 170 180 190 200
VSSRPTTPTV APPQAVSVPN KVATPVSVTS QRFAVQIPTS QSTPAKPAPA
210 220 230 240 250
ATSVQNVLIN PSMIGSKNIL ITTNMVSSQS TATDSNPLKR KHDDDDDDDD

DDDDNDTM
Length:258
Mass (Da):28,220
Last modified:January 10, 2006 - v2
Checksum:i42244D3E14F238B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171K → T in AAC53201 (PubMed:9168994).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40188 mRNA. Translation: AAC53201.1.
BC090332 mRNA. Translation: AAH90332.1.
PIRiJC5511.
RefSeqiNP_598299.1. NM_133615.1.
UniGeneiRn.11270.

Genome annotation databases

EnsembliENSRNOT00000091234; ENSRNOP00000073891; ENSRNOG00000061102.
GeneIDi171152.
KEGGirno:171152.
UCSCiRGD:621116. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40188 mRNA. Translation: AAC53201.1.
BC090332 mRNA. Translation: AAH90332.1.
PIRiJC5511.
RefSeqiNP_598299.1. NM_133615.1.
UniGeneiRn.11270.

3D structure databases

ProteinModelPortaliQ62880.
SMRiQ62880. Positions 13-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003335.

PTM databases

iPTMnetiQ62880.
PhosphoSiteiQ62880.

Proteomic databases

PaxDbiQ62880.
PRIDEiQ62880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091234; ENSRNOP00000073891; ENSRNOG00000061102.
GeneIDi171152.
KEGGirno:171152.
UCSCiRGD:621116. rat.

Organism-specific databases

CTDi51616.
RGDi621116. Taf9b.

Phylogenomic databases

eggNOGiKOG3334. Eukaryota.
COG5094. LUCA.
GeneTreeiENSGT00390000001626.
HOGENOMiHOG000231730.
HOVERGENiHBG002304.
InParanoidiQ62880.
KOiK03133.
OMAiNMANESN.
OrthoDBiEOG7HF1KM.
PhylomeDBiQ62880.
TreeFamiTF351417.

Enzyme and pathway databases

ReactomeiR-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiQ62880.

Gene expression databases

GenevisibleiQ62880. RN.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view]
PfamiPF02291. TFIID-31kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Heart.
  2. "Rat TAFII31 gene is induced upon programmed cell death in differentiated PC12 cells deprived of NGF."
    Aoki T., Koike T., Nakano T., Shibahara K., Nishimura H., Kikuchi H., Honjo T.
    Biochem. Biophys. Res. Commun. 234:230-234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-258, INDUCTION.

Entry informationi

Entry nameiTAF9B_RAT
AccessioniPrimary (citable) accession number: Q62880
Secondary accession number(s): Q5EAN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.