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Protein

Folate transporter 1

Gene

Slc19a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter for the intake of folate, reduced folates and methotrexate.

GO - Molecular functioni

  • folic acid binding Source: RGD
  • folic acid transporter activity Source: RGD
  • methotrexate transporter activity Source: RGD
  • reduced folate carrier activity Source: RGD

GO - Biological processi

  • female pregnancy Source: RGD
  • folic acid transport Source: RGD
  • methotrexate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Folate-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Folate transporter 1
Alternative name(s):
Reduced folate carrier 1
Short name:
RFC-1
Short name:
RFC1
Solute carrier family 19 member 1
Gene namesi
Name:Slc19a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3695. Slc19a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • brush border membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Folate transporter 1PRO_0000178662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei471 – 4711PhosphoserineBy similarity
Modified residuei476 – 4761PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62866.
PRIDEiQ62866.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041562.

Structurei

3D structure databases

ProteinModelPortaliQ62866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiQ62866.
PhylomeDBiQ62866.

Family and domain databases

InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PTHR10686:SF12. PTHR10686:SF12. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00806. rfc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPTGQVGEK QACEEPRQDR ELKSWRWLVF YLCFFGFMAQ LRPGESFITP
60 70 80 90 100
YLLERNFTKE QVTNEIIPML PYSHLAVLVP IFLLTDYLRY KPVLVLQCLS
110 120 130 140 150
FVCVWLLLLL GTSVVHMQLM EVFYSITMAA RIAYSSYIFS LVQPSRYQRM
160 170 180 190 200
ASYSRAAVLL GVFISSVLGQ VLVTLGGIST YMLNCISLGF ILFSLSLSLF
210 220 230 240 250
LKRPKRSLFF NRSALVQGAL PCELDQMHPG PGRPEPRKLE RMLGTCRDSF
260 270 280 290 300
LVRMLSELVK NVRQPQLRLW CLWWVFNSAG YYLITYYVHV LWKITDSRLN
310 320 330 340 350
YNGAVDAAST LLSAITAFTA GFVNIRWALW SKLVIASVIA IQAGLVFCMF
360 370 380 390 400
QIPDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA
410 420 430 440 450
TALKTSITLV VSDKRGLGLQ VHQQFRIYFM YFLTLSIICL AWAGLDGLRY
460 470 480 490 500
YRRGRHQPLA QAQALSPLED SVQAISLQDG DLRRPQPSAP QLLPEDGSVE
510
DGRADLRVEA KA
Length:512
Mass (Da):58,094
Last modified:November 1, 1996 - v1
Checksum:i71E1834F30337B44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38180 mRNA. Translation: AAC61788.1.
UniGeneiRn.9042.

Genome annotation databases

UCSCiRGD:3695. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38180 mRNA. Translation: AAC61788.1.
UniGeneiRn.9042.

3D structure databases

ProteinModelPortaliQ62866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041562.

Proteomic databases

PaxDbiQ62866.
PRIDEiQ62866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3695. rat.

Organism-specific databases

RGDi3695. Slc19a1.

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiQ62866.
PhylomeDBiQ62866.

Miscellaneous databases

PROiQ62866.

Family and domain databases

InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PTHR10686:SF12. PTHR10686:SF12. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00806. rfc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS19A1_RAT
AccessioniPrimary (citable) accession number: Q62866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.