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Protein
Submitted name:

Cytotoxic T-lymphocyte associated protein-4

Gene

Ctla4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • signaling receptor activity Source: RGD

GO - Biological processi

  • immune response Source: InterPro
  • negative regulation of immune response Source: RGD
  • negative regulation of T cell proliferation Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
Cytotoxic T-lymphocyte associated protein-4Imported
Gene namesi
Name:Ctla4Imported
Synonyms:CTLA-4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61975 Ctla4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei162 – 186HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

iPTMnetiQ62859
PhosphoSitePlusiQ62859

Expressioni

Gene expression databases

GenevisibleiQ62859 RN

Structurei

3D structure databases

ProteinModelPortaliQ62859
SMRiQ62859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 132Ig-likeInterPro annotationAdd BLAST101

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05 Eukaryota
ENOG410YUQR LUCA
HOGENOMiHOG000112047
HOVERGENiHBG057978
KOiK06538

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008096 CTLA4
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PANTHERiPTHR11494:SF8 PTHR11494:SF8, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR01720 CTLANTIGEN4
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q62859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLGLQRYK THLQLPSRTW PFGVLLSLLF IPIFSEAIQV TQPSVVLASS
60 70 80 90 100
HGVASFPCEY ASSHNTDEVR VTVLRQTNDQ VTEVCATTFT VKNTLGFLDD
110 120 130 140 150
PFCSGTFNES RVNLTIQGLR AADTGLYFCK VELMYPPPYF VGMGNGTQIY
160 170 180 190 200
VIDPEPCPDS DFLLWILAAV SSGLFFYSFL VTAVSLNRTL KKRSPLTTGV
210 220
YVKMPPTEPE CEKQFQPYFI PIN
Length:223
Mass (Da):24,859
Last modified:November 1, 1996 - v1
Checksum:iC19EE4F242C6A87B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37121 mRNA Translation: AAC52502.1
RefSeqiNP_113862.1, NM_031674.1
UniGeneiRn.10259

Genome annotation databases

GeneIDi63835
KEGGirno:63835

Similar proteinsi

Entry informationi

Entry nameiQ62859_RAT
AccessioniPrimary (citable) accession number: Q62859
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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