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Protein
Submitted name:

Cytotoxic T-lymphocyte associated protein-4

Gene

Ctla4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor activity Source: RGD

GO - Biological processi

  • immune response Source: InterPro
  • negative regulation of immune response Source: RGD
  • negative regulation of T cell proliferation Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cytotoxic T-lymphocyte associated protein-4Imported
Gene namesi
Name:Ctla4Imported
Synonyms:CTLA-4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61975. Ctla4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18625HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ62859.

PTM databases

iPTMnetiQ62859.
PhosphoSiteiQ62859.

Expressioni

Gene expression databases

GenevisibleiQ62859. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013941.

Structurei

3D structure databases

ProteinModelPortaliQ62859.
SMRiQ62859. Positions 38-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 132101Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
HOGENOMiHOG000112047.
HOVERGENiHBG057978.
KOiK06538.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLGLQRYK THLQLPSRTW PFGVLLSLLF IPIFSEAIQV TQPSVVLASS
60 70 80 90 100
HGVASFPCEY ASSHNTDEVR VTVLRQTNDQ VTEVCATTFT VKNTLGFLDD
110 120 130 140 150
PFCSGTFNES RVNLTIQGLR AADTGLYFCK VELMYPPPYF VGMGNGTQIY
160 170 180 190 200
VIDPEPCPDS DFLLWILAAV SSGLFFYSFL VTAVSLNRTL KKRSPLTTGV
210 220
YVKMPPTEPE CEKQFQPYFI PIN
Length:223
Mass (Da):24,859
Last modified:November 1, 1996 - v1
Checksum:iC19EE4F242C6A87B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37121 mRNA. Translation: AAC52502.1.
RefSeqiNP_113862.1. NM_031674.1.
UniGeneiRn.10259.

Genome annotation databases

GeneIDi63835.
KEGGirno:63835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37121 mRNA. Translation: AAC52502.1.
RefSeqiNP_113862.1. NM_031674.1.
UniGeneiRn.10259.

3D structure databases

ProteinModelPortaliQ62859.
SMRiQ62859. Positions 38-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013941.

PTM databases

iPTMnetiQ62859.
PhosphoSiteiQ62859.

Proteomic databases

PaxDbiQ62859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi63835.
KEGGirno:63835.

Organism-specific databases

CTDi1493.
RGDi61975. Ctla4.

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
HOGENOMiHOG000112047.
HOVERGENiHBG057978.
KOiK06538.

Gene expression databases

GenevisibleiQ62859. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ62859_RAT
AccessioniPrimary (citable) accession number: Q62859
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.