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Protein

Vomeronasal type-1 receptor 105

Gene

Vom1r105

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processPheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 105
Alternative name(s):
Pheromone receptor VN1
Vomeronasal type-1 receptor 51
Vomeronasal type-1 receptor A1
Short name:
Vomeronasal receptor 1
Gene namesi
Name:Vom1r105
Synonyms:Vmn1r51, Vnr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708382. Vom1r105.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 50CytoplasmicSequence analysisAdd BLAST12
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 94ExtracellularSequence analysisAdd BLAST23
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 135CytoplasmicSequence analysisAdd BLAST20
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 188ExtracellularSequence analysisAdd BLAST32
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 239CytoplasmicSequence analysisAdd BLAST30
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 271ExtracellularSequence analysisAdd BLAST11
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002399561 – 311Vomeronasal type-1 receptor 105Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 173PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62850.
PRIDEiQ62850.

Expressioni

Tissue specificityi

Expressed in 1-4% of neurons of the vomeronasal organ. Only one pheromone receptor gene may be expressed in a particular neuron. Not expressed in the main olfactory epithelium.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039516.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
HOVERGENiHBG101191.
InParanoidiQ62850.
KOiK04614.

Family and domain databases

CDDicd13949. 7tm_V1R_pheromone. 1 hit.
InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
PANTHERiPTHR24062. PTHR24062. 1 hit.
PfamiView protein in Pfam
PF03402. V1R. 1 hit.
PRINTSiPR01534. VOMERONASL1R.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKNSRLYT DSNIRNTFFA EIGIGVSANS LLLLFNIFKL ICGQRSRLTD
60 70 80 90 100
LPIGLLSLIN LLMLLMTAFI ATDTFISWRG WDDIICKSLL YLYRTFRGLS
110 120 130 140 150
LCTSCLLSVL QAIILSPRSS CLAKFKHKPS HHISCAILSL SVLYMFISSH
160 170 180 190 200
LLVSIIATPN LTTNDFIHVT QWCSILPMSY LMQSMFSTLL AIRDVFLISL
210 220 230 240 250
MVLSTWYMVA LLCRHRKQTR HLQGTSLSPK ASPEQRATRS ILMLMSLFVL
260 270 280 290 300
MSVFDSIVCS SRTMYLNDPI SYSYQLFMVH IYATVSPFVF IVTEKHIVNS
310
LRSMCVKVMN V
Length:311
Mass (Da):35,377
Last modified:June 13, 2006 - v2
Checksum:i8498FEC174EF2066
GO

Sequence cautioni

The sequence AAA92007 differs from that shown. Reason: Frameshift at position 309.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36785 mRNA. Translation: AAA92007.1. Frameshift.
RefSeqiNP_775136.1. NM_173113.1.
UniGeneiRn.144688.

Genome annotation databases

GeneIDi286893.
KEGGirno:286893.
UCSCiRGD:708382. rat.

Similar proteinsi

Entry informationi

Entry nameiVR105_RAT
AccessioniPrimary (citable) accession number: Q62850
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 22, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families