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Protein

Vomeronasal type-1 receptor 105

Gene

Vom1r105

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 105
Alternative name(s):
Pheromone receptor VN1
Vomeronasal type-1 receptor 51
Vomeronasal type-1 receptor A1
Short name:
Vomeronasal receptor 1
Gene namesi
Name:Vom1r105
Synonyms:Vmn1r51, Vnr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708382. Vom1r105.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence analysisAdd
BLAST
Transmembranei18 – 3821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 5012CytoplasmicSequence analysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini72 – 9423ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 13520CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 18832ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 23930CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27111ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Vomeronasal type-1 receptor 105PRO_0000239956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 173PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62850.
PRIDEiQ62850.

Expressioni

Tissue specificityi

Expressed in 1-4% of neurons of the vomeronasal organ. Only one pheromone receptor gene may be expressed in a particular neuron. Not expressed in the main olfactory epithelium.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
HOVERGENiHBG101191.
InParanoidiQ62850.
KOiK04614.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKNSRLYT DSNIRNTFFA EIGIGVSANS LLLLFNIFKL ICGQRSRLTD
60 70 80 90 100
LPIGLLSLIN LLMLLMTAFI ATDTFISWRG WDDIICKSLL YLYRTFRGLS
110 120 130 140 150
LCTSCLLSVL QAIILSPRSS CLAKFKHKPS HHISCAILSL SVLYMFISSH
160 170 180 190 200
LLVSIIATPN LTTNDFIHVT QWCSILPMSY LMQSMFSTLL AIRDVFLISL
210 220 230 240 250
MVLSTWYMVA LLCRHRKQTR HLQGTSLSPK ASPEQRATRS ILMLMSLFVL
260 270 280 290 300
MSVFDSIVCS SRTMYLNDPI SYSYQLFMVH IYATVSPFVF IVTEKHIVNS
310
LRSMCVKVMN V
Length:311
Mass (Da):35,377
Last modified:June 13, 2006 - v2
Checksum:i8498FEC174EF2066
GO

Sequence cautioni

The sequence AAA92007.1 differs from that shown. Reason: Frameshift at position 309. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36785 mRNA. Translation: AAA92007.1. Frameshift.
RefSeqiNP_775136.1. NM_173113.1.
UniGeneiRn.144688.

Genome annotation databases

GeneIDi286893.
KEGGirno:286893.
UCSCiRGD:708382. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36785 mRNA. Translation: AAA92007.1. Frameshift.
RefSeqiNP_775136.1. NM_173113.1.
UniGeneiRn.144688.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ62850.
PRIDEiQ62850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286893.
KEGGirno:286893.
UCSCiRGD:708382. rat.

Organism-specific databases

CTDi286893.
RGDi708382. Vom1r105.

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
HOVERGENiHBG101191.
InParanoidiQ62850.
KOiK04614.

Miscellaneous databases

NextBioi624965.
PROiQ62850.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel family of genes encoding putative pheromone receptors in mammals."
    Dulac C., Axel R.
    Cell 83:195-206(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
    Tissue: Vomeronasal organImported.

Entry informationi

Entry nameiVR105_RAT
AccessioniPrimary (citable) accession number: Q62850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 11, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.