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Protein

Contactin-4

Gene

Cntn4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.1 Publication

GO - Biological processi

  • axon guidance Source: InterPro
  • brain development Source: UniProtKB
  • cell adhesion Source: UniProtKB-KW
  • negative regulation of neuron differentiation Source: UniProtKB
  • nervous system development Source: UniProtKB
  • neuron projection development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-4
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 2
Short name:
BIG-2
Gene namesi
Name:Cntn4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621361. Cntn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 1000982Contactin-4PRO_0000014715Add
BLAST
Propeptidei1001 – 102626Removed in mature formSequence analysisPRO_0000014716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 194PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi247 ↔ 295PROSITE-ProRule annotation
Disulfide bondi337 ↔ 384PROSITE-ProRule annotation
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi429 ↔ 477PROSITE-ProRule annotation
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi519 ↔ 576PROSITE-ProRule annotation
Glycosylationi705 – 7051N-linked (GlcNAc...)Sequence analysis
Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence analysis
Glycosylationi858 – 8581N-linked (GlcNAc...)Sequence analysis
Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence analysis
Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence analysis
Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence analysis
Lipidationi1000 – 10001GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ62845.
PRIDEiQ62845.

PTM databases

PhosphoSiteiQ62845.

Expressioni

Tissue specificityi

Specifically expressed in the nervous system. Not expressed in heart, spleen, lung, liver, kidney or skeletal muscle. In the hippocampus, it is highly expressed in CA1 pyramidal cells and weakly expressed in other regions of the hippocampus.1 Publication

Gene expression databases

ExpressionAtlasiQ62845. baseline and differential.
GenevisibleiQ62845. RN.

Interactioni

Subunit structurei

Interacts with PTPRG.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007788.

Structurei

3D structure databases

ProteinModelPortaliQ62845.
SMRiQ62845. Positions 884-995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11786Ig-like C2-type 1Add
BLAST
Domaini122 – 20685Ig-like C2-type 2Add
BLAST
Domaini225 – 31187Ig-like C2-type 3Add
BLAST
Domaini316 – 40085Ig-like C2-type 4Add
BLAST
Domaini406 – 49388Ig-like C2-type 5Add
BLAST
Domaini497 – 58690Ig-like C2-type 6Add
BLAST
Domaini599 – 69799Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini702 – 79998Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini804 – 89996Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini900 – 99596Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ62845.
KOiK06762.
OMAiFIQEPSH.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ62845.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033007. Contactin-4.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF568. PTHR10489:SF568. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPWELLVL QSFMLCLADD YTLHGPVFVQ EPSHVMFPLD SEEKKVKLSC
60 70 80 90 100
EVKGNPKPHI RWKLNGTDVD IGMDFRYSVV EGSLLINNPN KTQDSGTYQC
110 120 130 140 150
IATNSFGTIV SREAKLQFAY LENFKTRTRS TVSVRRGQGM VLLCGPPPHS
160 170 180 190 200
GELSYAWIFN EHPSYQDNRR FVSQETGNLY IAKVEKADVG NYTCVVTNTV
210 220 230 240 250
TSHQVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPAEKG STVKLECFAL
260 270 280 290 300
GNPVPTILWR RADGKPIARK ARRHKSSGIL EIPNFQQEDA GSYECVAENS
310 320 330 340 350
RGKNIAKGQV TFYAQPNWVQ IINDIHVAME ESVFWECKAN GRPKPTYRWL
360 370 380 390 400
KNGDPLLTRE RIQIEQGTLN ITIVNLSDAG MYQCVAENKH GVIYASAELS
410 420 430 440 450
VIAESPDFSR TLLKRVTLVK VGGEVVIECK PKASPRPVYT WRKGREILRE
460 470 480 490 500
NERITISEDG NLRIINVTKS DAGSYTCIAT NHFGTASSTG NVVVKDPTKV
510 520 530 540 550
MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWTFNGHLI DFDKDGDHFE
560 570 580 590 600
RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDKLSAAAD LIVRGPPGPP
610 620 630 640 650
EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE
660 670 680 690 700
LVDGKTFTAT VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE
710 720 730 740 750
VTPANVSGGG GSKSELVITW ETVPEELQNG RGFGYVVAFR PHGKMIWMLT
760 770 780 790 800
VLASADASRY VFRNESVRPF SPFEVKVGVF NNKGEGPFSP TTLVYSAEEE
810 820 830 840 850
PTKPPASIFA RSLSATDIEV FWASPIGKNR GRIQGYEVKY WRHDDKEENA
860 870 880 890 900
RKIRTVGNQT STKITNLKGN ALYHLSVKAY NSAGTGPSSA AVNVTTRKPP
910 920 930 940 950
PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV
960 970 980 990 1000
IETNKTSVEL SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNSYARGS
1010 1020
GASTSNACTL SAISTIMISL TARSSL
Length:1,026
Mass (Da):113,393
Last modified:November 1, 1996 - v1
Checksum:iB60C0EEFA17BE3CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35371 mRNA. Translation: AAC52262.1.
RefSeqiNP_446331.1. NM_053879.1.
UniGeneiRn.10117.

Genome annotation databases

EnsembliENSRNOT00000007788; ENSRNOP00000007788; ENSRNOG00000005652.
GeneIDi116658.
KEGGirno:116658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35371 mRNA. Translation: AAC52262.1.
RefSeqiNP_446331.1. NM_053879.1.
UniGeneiRn.10117.

3D structure databases

ProteinModelPortaliQ62845.
SMRiQ62845. Positions 884-995.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007788.

PTM databases

PhosphoSiteiQ62845.

Proteomic databases

PaxDbiQ62845.
PRIDEiQ62845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007788; ENSRNOP00000007788; ENSRNOG00000005652.
GeneIDi116658.
KEGGirno:116658.

Organism-specific databases

CTDi152330.
RGDi621361. Cntn4.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ62845.
KOiK06762.
OMAiFIQEPSH.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ62845.
TreeFamiTF351103.

Miscellaneous databases

PROiQ62845.

Gene expression databases

ExpressionAtlasiQ62845. baseline and differential.
GenevisibleiQ62845. RN.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033007. Contactin-4.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF568. PTHR10489:SF568. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily."
    Yoshihara Y., Kawasaki M., Tamada A., Nagata S., Kagamiyama H., Mori K.
    J. Neurobiol. 28:51-69(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Brain.
  2. "Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain."
    Radom J., Colin D., Thiebault F., Dognin-Bergeret M.J., Mairet-Coello G., Esnard-Feve A., Fellmann D., Jouvenot M.
    Biochim. Biophys. Acta 1759:225-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCNTN4_RAT
AccessioniPrimary (citable) accession number: Q62845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.