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Protein

Ameloblastin

Gene

Ambn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the mineralization and structural organization of enamel.

GO - Molecular functioni

  • structural constituent of tooth enamel Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Ameloblastin
Short name:
Amelin
Gene namesi
Name:Ambn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2101. Ambn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 422396AmeloblastinPRO_0000001195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421HydroxyprolineBy similarity
Modified residuei48 – 481PhosphoserineBy similarity
Glycosylationi117 – 1171O-linked (GalNAc...)By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiQ62840.

Expressioni

Tissue specificityi

Ameloblast-specific.

Interactioni

Protein-protein interaction databases

IntActiQ62840. 8 interactions.
STRINGi10116.ENSRNOP00000005003.

Family & Domainsi

Sequence similaritiesi

Belongs to the ameloblastin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMU1. Eukaryota.
ENOG41128SS. LUCA.
GeneTreeiENSGT00390000018227.
HOGENOMiHOG000033918.
HOVERGENiHBG007128.
InParanoidiQ62840.
OMAiWMHGLLP.
OrthoDBiEOG091G0EPP.
PhylomeDBiQ62840.
TreeFamiTF337860.

Family and domain databases

InterProiIPR007798. Amelin.
[Graphical view]
PANTHERiPTHR14115. PTHR14115. 1 hit.
PfamiPF05111. Amelin. 1 hit.
[Graphical view]
SMARTiSM00817. Amelin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62840-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASKIPLFK MKGLLLFLSL VKMSLAVPAF PQQPGAQGMA PPGMASLSLE
60 70 80 90 100
TMRQLGSLQG LNALSQYSRL GFGKALNSLW LHGLLPPHNS FPWIGPREHE
110 120 130 140 150
TQQYEYSLPV HPPPLPSQPS LQPHQPGLKP FLQPTAATGV QVTPQKPGPH
160 170 180 190 200
PPMHPGQLPL QEGELIAPDE PQVAPSENPP TPEVPIMDFA DPQFPTVFQI
210 220 230 240 250
AHSLSRGPMA HNKVPTFYPG MFYMSYGANQ LNAPARIGFM SSEEMPGERG
260 270 280 290 300
SPMAYGTLFP GYGGFRQTLR GLNQNSPKGG DFTVEVDSPV SVTKGPEKGE
310 320 330 340 350
GPEGSPLQEA SPDKGENPAL LSQMAPGAHA GLLAFPNDHI PNMARGPAGQ
360 370 380 390 400
RLLGVTPAAA DPLITPELAE VYETYGADVT TPLGDGEATM DITMSPDTQQ
410 420
PPMPGNKVHQ PQVHNAWRFQ EP
Length:422
Mass (Da):45,206
Last modified:November 1, 1996 - v1
Checksum:i0F983772E9082A89
GO
Isoform 2 (identifier: Q62840-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-118: Missing.

Show »
Length:407
Mass (Da):43,501
Checksum:iF7C5EDDA0A775642
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241M → I in CAA90414 (PubMed:8797107).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 11815Missing in isoform 2. 1 PublicationVSP_000226Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35097 mRNA. Translation: AAC52428.1.
Z50083 mRNA. Translation: CAA90414.1.
AY159302
, AY159295, AY159296, AY159297, AY159298, AY159299, AY159300 Genomic DNA. Translation: AAN71737.1.
RefSeqiNP_037032.1. NM_012900.1. [Q62840-1]
UniGeneiRn.11370.

Genome annotation databases

EnsembliENSRNOT00000005003; ENSRNOP00000005003; ENSRNOG00000003718. [Q62840-1]
GeneIDi25376.
KEGGirno:25376.
UCSCiRGD:2101. rat. [Q62840-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35097 mRNA. Translation: AAC52428.1.
Z50083 mRNA. Translation: CAA90414.1.
AY159302
, AY159295, AY159296, AY159297, AY159298, AY159299, AY159300 Genomic DNA. Translation: AAN71737.1.
RefSeqiNP_037032.1. NM_012900.1. [Q62840-1]
UniGeneiRn.11370.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62840. 8 interactions.
STRINGi10116.ENSRNOP00000005003.

Proteomic databases

PaxDbiQ62840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005003; ENSRNOP00000005003; ENSRNOG00000003718. [Q62840-1]
GeneIDi25376.
KEGGirno:25376.
UCSCiRGD:2101. rat. [Q62840-1]

Organism-specific databases

CTDi258.
RGDi2101. Ambn.

Phylogenomic databases

eggNOGiENOG410IMU1. Eukaryota.
ENOG41128SS. LUCA.
GeneTreeiENSGT00390000018227.
HOGENOMiHOG000033918.
HOVERGENiHBG007128.
InParanoidiQ62840.
OMAiWMHGLLP.
OrthoDBiEOG091G0EPP.
PhylomeDBiQ62840.
TreeFamiTF337860.

Miscellaneous databases

PROiQ62840.

Family and domain databases

InterProiIPR007798. Amelin.
[Graphical view]
PANTHERiPTHR14115. PTHR14115. 1 hit.
PfamiPF05111. Amelin. 1 hit.
[Graphical view]
SMARTiSM00817. Amelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMBN_RAT
AccessioniPrimary (citable) accession number: Q62840
Secondary accession number(s): Q540J9, Q63043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.