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Reviewed, UniProtKB/Swiss-Prot Q62838 (MUSK_RAT)

Last modified June 16, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Muscle, skeletal receptor tyrosine protein kinase
    EC=2.7.10.1
Alternative name(s):
    Muscle-specific kinase receptor
      Short name=MuSK
Gene names
Name: Musk
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length868 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with DOK7, which probably regulates its activity By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Muscle specific. Ref.1

Developmental stage

From E14.0 day, expressed in developing myotomes. Once the muscle is innervated, localized to the neuromuscular junction (NMJ), where its expression is restricted to synaptic nuclei. Declined slowly to adult. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 FZ (frizzled) domain.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Lrp4Q8VI561EBI-2106354,EBI-2106160From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 868847Muscle, skeletal receptor tyrosine protein kinase
PRO_0000024448

Regions

Topological domain22 – 494473Extracellular Potential
Transmembrane495 – 51521 Potential
Topological domain516 – 868353Cytoplasmic Potential
Domain28 – 11689Ig-like 1
Domain121 – 20585Ig-like 2
Domain212 – 30291Ig-like 3
Domain312 – 450139FZ
Domain574 – 855282Protein kinase
Nucleotide binding580 – 5889ATP By similarity

Sites

Active site7241Proton acceptor By similarity
Binding site6081ATP By similarity

Amino acid modifications

Modified residue7541Phosphotyrosine; by autocatalysis By similarity
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation3381N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 99 By similarity
Disulfide bond142 ↔ 190 By similarity
Disulfide bond233 ↔ 282 By similarity
Disulfide bond317 ↔ 382 By similarity
Disulfide bond325 ↔ 375 By similarity
Disulfide bond366 ↔ 406 By similarity
Disulfide bond394 ↔ 447 By similarity
Disulfide bond398 ↔ 434 By similarity

Secondary structure

1 .............................................................................................. 868
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q62838-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C146B4E74EE25B24

FASTA86896,822
        10         20         30         40         50         60 
MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 

        70         80         90        100        110        120 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 

       130        140        150        160        170        180 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSA LRENSRIAVL ESGSLRIHNV 

       190        200        210        220        230        240 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGMPV 

       250        260        270        280        290        300 
PTISWIENGN AVSSGSIQEN VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 

       310        320        330        340        350        360 
VSIAEWSKSQ KESKGYCAQY RGEVCDAVLV KDSLVFFNTS YPDPEEAQEL LIHTAWNELK 

       370        380        390        400        410        420 
AVSPLCRPAA EALLCNHLFQ ECSPGVLPTP MPICREYCLA VKELFCAKEW LAMEGKTHRG 

       430        440        450        460        470        480 
LYRSGMHFLP VPECSKLPSM HQDPTACTRL PYLDYKKENI TTFPSITSSK PSVDIPNLPA 

       490        500        510        520        530        540 
STSSFAVSPA YSMTVIISIM SCFAVFALLT ITTLYCCRRR REWKNKKRES AAVTLTTLPS 

       550        560        570        580        590        600 
ELLLDRLHPN PMYQRMPLLL NPKLLSLEYP RNNIEYVRDI GEGAFGRVFQ ARAPGLLPYE 

       610        620        630        640        650        660 
PFTMVAVKML KEEASADMQA DFQREAALMA EFDNPNIVKL LGVCAVGKPM CLLFEYMAYG 

       670        680        690        700        710        720 
DLNEFLRSMS PHTVCSLSHS DLSTRARVSS PGPPPLSCAE QLCIARQVAA GMAYLSERKF 

       730        740        750        760        770        780 
VHRDLATRNC LVGENMVVKI ADFGLSRNIY SADYYKADGN DAIPIRWMPP ESIFYNRYTT 

       790        800        810        820        830        840 
ESDVWAYGVV LWEIFSYGLQ PYYGMAHEEV IYYVRDGNIL ACPENCPLEL YNLMRLCWSK 

       850        860 
LPADRPSFCS IHRILQRMCE RAEGTVGV

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References

[1]"Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury."
Valenzuela D.M., Stitt T.N., DiStefano P.S., Rojas E., Mattsson K., Compton D.L., Nunez L., Park J.S., Stark J.L., Gies D.R., Thomas S., LeBeau M.M., Fernald A.A., Copeland N.G., Jenkins N.A., Burden S.J., Glass D.J., Yancopoulos G.D.
Neuron 15:573-584(1995) [PubMed: 7546737] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Muscle.
[2]"Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation."
Till J.H., Becerra M., Watty A., Lu Y., Ma Y., Neubert T.A., Burden S.J., Hubbard S.R.
Structure 10:1187-1196(2002) [PubMed: 12220490] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 560-860.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U34985 mRNA. Translation: AAA90956.1.
IPIIPI00209185.
RefSeqNP_112323.1.
UniGeneRn.10210

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1LUFX-ray2.05A529-868[»]
2IEPX-ray2.21A/B22-212[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ62838. 2 interactions.

PTM databases

PhosphoSiteQ62838.

Genome annotation databases

EnsemblENSRNOG00000033567. Rattus norvegicus. [Contig view]
GeneID81725.
KEGGrno:81725.

Organism-specific databases

RGD3211. Musk.

Phylogenomic databases

HOVERGENQ62838.

Enzyme and pathway databases

BRENDA2.7.10.1. 248.

Gene expression databases

ArrayExpressQ62838.
GermOnlineENSRNOG00000033567. Rattus norvegicus.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio615376.

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Entry information

Entry nameMUSK_RAT
AccessionPrimary (citable) accession number: Q62838
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents