Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rab GTPase-binding effector protein 2

Gene

Rabep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in membrane trafficking and in homotypic early endosome fusion.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-binding effector protein 2
Alternative name(s):
MP13 protein
Rabaptin-5beta
Gene namesi
Name:Rabep2
Synonyms:Rabpt5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621416. Rabep2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Rab GTPase-binding effector protein 2PRO_0000187561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62835.
PRIDEiQ62835.

Interactioni

Subunit structurei

Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi249480. 1 interaction.
STRINGi10116.ENSRNOP00000025043.

Structurei

3D structure databases

ProteinModelPortaliQ62835.
SMRiQ62835. Positions 495-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 173159Sequence analysisAdd
BLAST
Coiled coili274 – 512239Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 1005Poly-Gln
Compositional biasi270 – 420151Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the rabaptin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0993. Eukaryota.
ENOG410XSZ1. LUCA.
HOGENOMiHOG000154063.
HOVERGENiHBG108391.
InParanoidiQ62835.
PhylomeDBiQ62835.

Family and domain databases

InterProiIPR003914. Rabaptin.
IPR029882. Rabaptin-5beta.
IPR018514. Rabaptin_coiled-coil.
IPR015390. Rabaptin_Rab5-bd_dom.
[Graphical view]
PANTHERiPTHR31179:SF6. PTHR31179:SF6. 1 hit.
PfamiPF09311. Rab5-bind. 1 hit.
PF03528. Rabaptin. 1 hit.
[Graphical view]
PRINTSiPR01432. RABAPTIN.

Sequencei

Sequence statusi: Complete.

Q62835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPAALAL DPQPQEEQKD ASESSELSRL RAELAGALAE METMKAVAEV
60 70 80 90 100
SESTKAEAVA AVQRQCQEEV ASLQAILKDS ISSYETQIAA LKQERQQQQQ
110 120 130 140 150
DSEEKERELG HLKQLLARAH PLDSLEKQME KAHEDSEKLR EIVLPMEQEI
160 170 180 190 200
AELKVKLLRA EELIQEIQRR PRQPASLHGS TELLPLSRNP SPPLEPSEEP
210 220 230 240 250
SGDAGPAAEA FAHNCDDSAS ISSFSLGGAA GSVSLRGPQG LSPEQEETAS
260 270 280 290 300
LVSTGTLVPE GIYLPPPGYQ LVPDSQWEQL QVEGRQLQKE LESVRRERDE
310 320 330 340 350
LQEGLSRSNE DCAKQMQVLL AQVQNSEQLL RTLQGTVSQA QERVQRQMAE
360 370 380 390 400
LATSHKCLSQ EVKRLNEENR GLRAEQLPSS ALQGSEQQED QDEALPSSIQ
410 420 430 440 450
ELHQLVRHTR QQARARQQAQ EHEAERLRIE IVKLREALDE ETAAKASLEG
460 470 480 490 500
QLRVQREETD VLEASLCSLR IETERVQQEH HKAQLTDLLS EQRAKALRLQ
510 520 530 540 550
AELETSEQVQ RDFVRLSQAL QVRLEQIRQA DTLEQVRSIL DEAPLRDIKD

IKDS
Length:554
Mass (Da):61,973
Last modified:November 1, 1996 - v1
Checksum:i39448FAF2B41A004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34932 mRNA. Translation: AAA79137.1.
RefSeqiNP_085074.1. NM_030585.1.
UniGeneiRn.3228.

Genome annotation databases

GeneIDi80754.
KEGGirno:80754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34932 mRNA. Translation: AAA79137.1.
RefSeqiNP_085074.1. NM_030585.1.
UniGeneiRn.3228.

3D structure databases

ProteinModelPortaliQ62835.
SMRiQ62835. Positions 495-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249480. 1 interaction.
STRINGi10116.ENSRNOP00000025043.

Proteomic databases

PaxDbiQ62835.
PRIDEiQ62835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80754.
KEGGirno:80754.

Organism-specific databases

CTDi79874.
RGDi621416. Rabep2.

Phylogenomic databases

eggNOGiKOG0993. Eukaryota.
ENOG410XSZ1. LUCA.
HOGENOMiHOG000154063.
HOVERGENiHBG108391.
InParanoidiQ62835.
PhylomeDBiQ62835.

Miscellaneous databases

NextBioi614862.
PROiQ62835.

Family and domain databases

InterProiIPR003914. Rabaptin.
IPR029882. Rabaptin-5beta.
IPR018514. Rabaptin_coiled-coil.
IPR015390. Rabaptin_Rab5-bd_dom.
[Graphical view]
PANTHERiPTHR31179:SF6. PTHR31179:SF6. 1 hit.
PfamiPF09311. Rab5-bind. 1 hit.
PF03528. Rabaptin. 1 hit.
[Graphical view]
PRINTSiPR01432. RABAPTIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation."
    Feng Z., Hong J., Qi Q., Han Y., Wilson B., Iadarola M., Tiao N., Bing G.
    Neurosci. Lett. 296:129-132(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
    Tissue: Hippocampus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRABE2_RAT
AccessioniPrimary (citable) accession number: Q62835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.