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Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • protein complex binding Source: RGD

GO - Biological processi

  • chemical synaptic transmission Source: RGD
  • establishment of cell polarity Source: RGD
  • Golgi to transport vesicle transport Source: RGD
  • membrane biogenesis Source: RGD
  • oligodendrocyte differentiation Source: RGD
  • positive regulation of calcium-mediated signaling Source: RGD
  • protein targeting to membrane Source: UniProtKB
  • regulation of protein transport Source: UniProtKB
  • vesicle docking involved in exocytosis Source: InterPro
  • vesicle targeting Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Short name:
rSec8
Gene namesi
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621791. Exoc4.

Subcellular locationi

GO - Cellular componenti

  • dendritic shaft Source: UniProtKB
  • exocyst Source: UniProtKB
  • growth cone Source: UniProtKB
  • myelin sheath Source: RGD
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • postsynaptic density Source: UniProtKB
  • protein complex Source: RGD
  • synapse Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 975974Exocyst complex component 4PRO_0000118936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineCombined sources
Modified residuei238 – 2381PhosphothreonineBy similarity
Modified residuei469 – 4691PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ62824.

PTM databases

iPTMnetiQ62824.
PhosphoSiteiQ62824.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity1 Publication

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi250539. 2 interactions.
DIPiDIP-40985N.
IntActiQ62824. 1 interaction.
MINTiMINT-87397.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11483Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000044203.
HOVERGENiHBG036151.
InParanoidiQ62824.
KOiK06111.
PhylomeDBiQ62824.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKMSS HGKDASPGPL IDVSNISTPR KFLDATQYSA
260 270 280 290 300
AGSSSVREMN LQDIKEDLDC DPEENSTLFM GILIQGLARL KKIPETVKAI
310 320 330 340 350
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF
360 370 380 390 400
NAVASAHSIV LGYLQDSVGT QPTQQEEIKL YDMADVWVKI QDVLQMLLTE
410 420 430 440 450
YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH
460 470 480 490 500
AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI
510 520 530 540 550
FHPLLRFIQE IEHALGLGPA KQCLLREFLT IYIKNIFLNQ VLTEINKEIE
560 570 580 590 600
GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA
610 620 630 640 650
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL
660 670 680 690 700
KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD
710 720 730 740 750
ILRDVSDLKA LANMHESLEW LAGRTKSAFS SLSASQMLSP AQESHVNMDL
760 770 780 790 800
PPVSEQIMQT LSELAKSFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY
810 820 830 840 850
AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS
860 870 880 890 900
CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY
910 920 930 940 950
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL
960 970
QRLKEIICEQ AAIKQATKDK KITTV
Length:975
Mass (Da):110,553
Last modified:November 1, 1996 - v1
Checksum:iC52FD3553BE75858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32498 mRNA. Translation: AAC52265.1.
PIRiI59422.
RefSeqiNP_446327.1. NM_053875.1.
UniGeneiRn.51841.

Genome annotation databases

GeneIDi116654.
KEGGirno:116654.
UCSCiRGD:621791. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32498 mRNA. Translation: AAC52265.1.
PIRiI59422.
RefSeqiNP_446327.1. NM_053875.1.
UniGeneiRn.51841.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250539. 2 interactions.
DIPiDIP-40985N.
IntActiQ62824. 1 interaction.
MINTiMINT-87397.

PTM databases

iPTMnetiQ62824.
PhosphoSiteiQ62824.

Proteomic databases

PRIDEiQ62824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116654.
KEGGirno:116654.
UCSCiRGD:621791. rat.

Organism-specific databases

CTDi60412.
RGDi621791. Exoc4.

Phylogenomic databases

HOGENOMiHOG000044203.
HOVERGENiHBG036151.
InParanoidiQ62824.
KOiK06111.
PhylomeDBiQ62824.

Miscellaneous databases

PROiQ62824.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC4_RAT
AccessioniPrimary (citable) accession number: Q62824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.