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Protein

Transcription factor E2F5

Gene

E2f5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi2 – 73Sequence analysisAdd BLAST72

GO - Molecular functioni

  • DNA binding transcription factor activity Source: RGD
  • protein dimerization activity Source: InterPro
  • sequence-specific DNA binding Source: RGD

GO - Biological processi

  • cell projection organization Source: UniProtKB-KW
  • regulation of cell cycle Source: RGD
  • regulation of transcription, DNA-templated Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCilium biogenesis/degradation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E2F5
Short name:
E2F-5
Gene namesi
Name:E2f5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621357 E2f5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000219471‹1 – 300Transcription factor E2F5Add BLAST›300

Proteomic databases

PaxDbiQ62814

Expressioni

Tissue specificityi

Found in placenta followed by kidney, lung and brain.

Interactioni

Subunit structurei

Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044464

Structurei

3D structure databases

ProteinModelPortaliQ62814
SMRiQ62814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 53Leucine-zipperAdd BLAST23
Regioni74 – 170DimerizationSequence analysisAdd BLAST97
Regioni242 – 300TransactivationSequence analysisAdd BLAST59
Regioni277 – 294RBL2 associationSequence analysisAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 73DEF boxAdd BLAST38

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2577 Eukaryota
ENOG410XNYI LUCA
HOGENOMiHOG000232045
HOVERGENiHBG002227
InParanoidiQ62814
PhylomeDBiQ62814

Family and domain databases

CDDicd14660 E2F_DD, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR015633 E2F
IPR037241 E2F-DP_heterodim
IPR028316 E2F5
IPR032198 E2F_CC-MB
IPR003316 E2F_WHTH_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12081 PTHR12081, 2 hits
PTHR12081:SF35 PTHR12081:SF35, 2 hits
PfamiView protein in Pfam
PF16421 E2F_CC-MB, 1 hit
PF02319 E2F_TDP, 1 hit
SMARTiView protein in SMART
SM01372 E2F_TDP, 1 hit
SUPFAMiSSF144074 SSF144074, 1 hit
SSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Fragment.

Q62814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GGSSRHEKSL GLLTTKFVSL LQEAQDGVLD LKAAADTLAV RQKRRIYDIT
60 70 80 90 100
NVLEGIDLIE KKSKNSIQWK GVGAGCNTKE VIDRLRCLKA EIEDLELKER
110 120 130 140 150
ELDQQKLWLQ QSIKNVMEDS INNRFSYVTH EDICSCFNGD TLLAIQAPSG
160 170 180 190 200
TQLEVPIPEM GQNGQKKYQI NLKSHSGPIH VLLINKESNS SKPVVFPVPP
210 220 230 240 250
PDDLTQPSSQ SSTSVTPPKS TMAAQNLPEQ HVSERSQNFQ QTPATEISSG
260 270 280 290 300
SISGDIIDEL MSSDVFPLLR LSPTPADDYN FNLDDNEGVC DLFDVQILNY
Length:300
Mass (Da):33,224
Last modified:November 1, 1996 - v1
Checksum:i3FAF0AEA8875541E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31668 mRNA Translation: AAB00180.1
UniGeneiRn.52317

Genome annotation databases

UCSCiRGD:621357 rat

Similar proteinsi

Entry informationi

Entry nameiE2F5_RAT
AccessioniPrimary (citable) accession number: Q62814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health