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Protein

Limbic system-associated membrane protein

Gene

Lsamp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Gene namesi
Name:Lsamp
Synonyms:Lamp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71102. Lsamp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001510629 – 315Limbic system-associated membrane proteinAdd BLAST287
PropeptideiPRO_0000015107316 – 338Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Modified residuei94PhosphotyrosineBy similarity1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Lipidationi315GPI-anchor amidated asparagine; alternateSequence analysis1
Glycosylationi315N-linked (GlcNAc...); alternateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ62813.

PTM databases

iPTMnetiQ62813.
PhosphoSitePlusiQ62813.
UniCarbKBiQ62813.

Expressioni

Tissue specificityi

Expressed mostly by neurons comprising limbic-associated cortical and subcortical regions that function in cognition, emotion, memory, and learning.

Developmental stagei

First detected at E15-16, at stage E20 it is detected in presumptive cortex, medial limbic areas of the thalamus and hypothalamus. In the adult, it is found in hypothalamus, perirhinal cortex, amygdala and medial thalamic region.

Gene expression databases

BgeeiENSRNOG00000031852.
GenevisibleiQ62813. RN.

Structurei

3D structure databases

ProteinModelPortaliQ62813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 122Ig-like C2-type 1Add BLAST94
Domaini132 – 214Ig-like C2-type 2Add BLAST83
Domaini219 – 304Ig-like C2-type 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ62813.
KOiK06772.
OrthoDBiEOG091G0B5D.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH ALEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP LGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LFCLLSKC
Note: GPI-anchored form.
Length:338
Mass (Da):37,324
Last modified:November 1, 1996 - v1
Checksum:i0B76AFDD68A39BB6
GO
Isoform 2 (identifier: Q62813-2) [UniParc]FASTAAdd to basket
Also known as: 6C

The sequence of this isoform differs from the canonical sequence as follows:
     307-307: R → KRVLPTVPHPIQEIGTTVHFKQKG

Show »
Length:361
Mass (Da):39,861
Checksum:iCF93DECA78E1EC59
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011601307R → KRVLPTVPHPIQEIGTTVHF KQKG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31554 mRNA. Translation: AAA86120.1.
AY326256 mRNA. Translation: AAQ91613.1.
RefSeqiNP_058938.1. NM_017242.1. [Q62813-1]
XP_006248401.1. XM_006248339.3. [Q62813-2]
UniGeneiRn.10176.

Genome annotation databases

GeneIDi29561.
KEGGirno:29561.
UCSCiRGD:71102. rat. [Q62813-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31554 mRNA. Translation: AAA86120.1.
AY326256 mRNA. Translation: AAQ91613.1.
RefSeqiNP_058938.1. NM_017242.1. [Q62813-1]
XP_006248401.1. XM_006248339.3. [Q62813-2]
UniGeneiRn.10176.

3D structure databases

ProteinModelPortaliQ62813.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ62813.
PhosphoSitePlusiQ62813.
UniCarbKBiQ62813.

Proteomic databases

PRIDEiQ62813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29561.
KEGGirno:29561.
UCSCiRGD:71102. rat. [Q62813-1]

Organism-specific databases

CTDi4045.
RGDi71102. Lsamp.

Phylogenomic databases

HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ62813.
KOiK06772.
OrthoDBiEOG091G0B5D.
TreeFamiTF325565.

Miscellaneous databases

PROiQ62813.

Gene expression databases

BgeeiENSRNOG00000031852.
GenevisibleiQ62813. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSAMP_RAT
AccessioniPrimary (citable) accession number: Q62813
Secondary accession number(s): Q6VUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.