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Protein

Noggin

Gene

Nog

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

GO - Biological processi

  • cartilage development Source: UniProtKB-KW
  • epithelial to mesenchymal transition Source: UniProtKB
  • forebrain development Source: RGD
  • hippocampus development Source: RGD
  • memory Source: RGD
  • negative regulation of astrocyte differentiation Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: UniProtKB
  • negative regulation of cardiac muscle cell proliferation Source: UniProtKB
  • ossification Source: RGD
  • osteoblast differentiation Source: UniProtKB
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of glomerulus development Source: UniProtKB
  • positive regulation of oligodendrocyte progenitor proliferation Source: RGD
  • skeletal system development Source: GO_Central
  • visual learning Source: RGD
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin
Gene namesi
Name:Nog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3183. Nog.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 4›4Sequence analysis
Chaini5 – 144140NogginPRO_0000019815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 104By similarity
Disulfide bondi90 ↔ 140By similarity
Disulfide bondi96 ↔ 142By similarity
Disulfide bondi119 ↔ 127By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62809.
PRIDEiQ62809.

Expressioni

Tissue specificityi

Prominently expressed in the CNS. High levels found in mitral and tufted cells in the olfactory bulb, piriform cortex of the brain and Purkinje cells in the cerebellum. Low level expression seen in the lung, skeletal muscle and skin.

Developmental stagei

First detected at embryonic day 9 and in the brain, expression increases steadily from embryonic day 17 to postnatal day 19.

Interactioni

Subunit structurei

Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030212.

Structurei

3D structure databases

ProteinModelPortaliQ62809.
SMRiQ62809. Positions 8-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIR6. Eukaryota.
ENOG410Z62S. LUCA.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiQ62809.
PhylomeDBiQ62809.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494:SF5. PTHR10494:SF5. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GGGGGPAGGA EDLAELDQLL RQRPSGAMPS EIKGLEFSEG LAQGKKQRLS
60 70 80 90 100
KKLRRKLQMW LWSQTFCPVL YAWNDLGSRF WARYVKVGSC FSKRSCSVPE
110 120 130 140
GMVCKPSKSV HLTVLRWRCQ RRGGQRCGWI PIQYPIISEC KCSC
Length:144
Mass (Da):16,139
Last modified:November 1, 1996 - v1
Checksum:i53BBE432B0D7298D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31203 mRNA. Translation: AAA83260.1.
UniGeneiRn.10154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31203 mRNA. Translation: AAA83260.1.
UniGeneiRn.10154.

3D structure databases

ProteinModelPortaliQ62809.
SMRiQ62809. Positions 8-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030212.

Proteomic databases

PaxDbiQ62809.
PRIDEiQ62809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3183. Nog.

Phylogenomic databases

eggNOGiENOG410IIR6. Eukaryota.
ENOG410Z62S. LUCA.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiQ62809.
PhylomeDBiQ62809.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494:SF5. PTHR10494:SF5. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOGG_RAT
AccessioniPrimary (citable) accession number: Q62809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.