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Protein

Synaptotagmin-17

Gene

Syt17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in dendrite formation by melanocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-17
Alternative name(s):
Protein B/K
Synaptotagmin XVII
Short name:
SytXVII
Gene namesi
Name:Syt17
Synonyms:Bk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi708576. Syt17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Synaptotagmin-17PRO_0000311939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineCombined sources
Modified residuei119 – 1191PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62807.
PRIDEiQ62807.

PTM databases

iPTMnetiQ62807.
PhosphoSiteiQ62807.
SwissPalmiQ62807.

Expressioni

Tissue specificityi

Expressed in brain and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000017136.
ExpressionAtlasiQ62807. baseline and differential.
GenevisibleiQ62807. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023090.

Structurei

3D structure databases

ProteinModelPortaliQ62807.
SMRiQ62807. Positions 182-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 294109C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 426104C2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 4018Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000154478.
HOVERGENiHBG108530.
InParanoidiQ62807.
KOiK19915.
OMAiDGARQDM.
OrthoDBiEOG091G0E6G.
PhylomeDBiQ62807.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR014705. SYT17.
[Graphical view]
PANTHERiPTHR10024:SF251. PTHR10024:SF251. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYIQLEPLN EGFLSRISDV LLCGWTCQHC CQRCYESSCC QSSEDEVEIL
60 70 80 90 100
GPFPAQTPPW LMASRSNDKD GDSVHTASDV PLTPRTNSPD GRRSSSDTSK
110 120 130 140 150
STYSLTRRIS SLDSRRPSSP LIDIKPIEFG VLSAKKEPIQ PSVLRRTYTP
160 170 180 190 200
DDYFRKFEPR LYSLDSNLDD VDSLTDEEIM SKYQLGMLHF STQYDLLHNH
210 220 230 240 250
LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK NSKQTGVKRK
260 270 280 290 300
TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVAVPLCEV
310 320 330 340 350
DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DIIRAKQLLQ
360 370 380 390 400
TDVSQGSDPF VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE
410 420 430 440 450
LENASLVFTV FGHNMKSSND FIGRIVIGQY SSGPSESNHW RRMLNTHRTA
460 470
VEQWHSLRSR AECDRVSPAS LEVT
Length:474
Mass (Da):53,827
Last modified:November 1, 1996 - v1
Checksum:i048ACA8CE20D3F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30831 mRNA. Translation: AAC52379.1.
PIRiS68695.
RefSeqiNP_620204.1. NM_138849.1.
UniGeneiRn.31973.

Genome annotation databases

EnsembliENSRNOT00000023090; ENSRNOP00000023090; ENSRNOG00000017136.
GeneIDi192189.
KEGGirno:192189.
UCSCiRGD:708576. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30831 mRNA. Translation: AAC52379.1.
PIRiS68695.
RefSeqiNP_620204.1. NM_138849.1.
UniGeneiRn.31973.

3D structure databases

ProteinModelPortaliQ62807.
SMRiQ62807. Positions 182-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023090.

PTM databases

iPTMnetiQ62807.
PhosphoSiteiQ62807.
SwissPalmiQ62807.

Proteomic databases

PaxDbiQ62807.
PRIDEiQ62807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023090; ENSRNOP00000023090; ENSRNOG00000017136.
GeneIDi192189.
KEGGirno:192189.
UCSCiRGD:708576. rat.

Organism-specific databases

CTDi51760.
RGDi708576. Syt17.

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000154478.
HOVERGENiHBG108530.
InParanoidiQ62807.
KOiK19915.
OMAiDGARQDM.
OrthoDBiEOG091G0E6G.
PhylomeDBiQ62807.
TreeFamiTF315600.

Miscellaneous databases

PROiQ62807.

Gene expression databases

BgeeiENSRNOG00000017136.
ExpressionAtlasiQ62807. baseline and differential.
GenevisibleiQ62807. RN.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR014705. SYT17.
[Graphical view]
PANTHERiPTHR10024:SF251. PTHR10024:SF251. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT17_RAT
AccessioniPrimary (citable) accession number: Q62807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.