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Protein

Galanin receptor type 1

Gene

Galr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.By similarity1 Publication

GO - Molecular functioni

  • galanin receptor activity Source: RGD
  • neuropeptide binding Source: RGD
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2656. Galr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 69CytoplasmicSequence analysisAdd BLAST15
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 108ExtracellularSequence analysisAdd BLAST18
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 150CytoplasmicSequence analysisAdd BLAST20
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 196ExtracellularSequence analysisAdd BLAST25
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 246CytoplasmicSequence analysisAdd BLAST29
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 269ExtracellularSequence analysis2
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 346CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5504.
GuidetoPHARMACOLOGYi243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694651 – 346Galanin receptor type 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 185
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi318S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ62805.
PRIDEiQ62805.

PTM databases

PhosphoSitePlusiQ62805.

Expressioni

Tissue specificityi

Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.1 Publication

Gene expression databases

BgeeiENSRNOG00000016654.
GenevisibleiQ62805. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022400.

Chemistry databases

BindingDBiQ62805.

Structurei

3D structure databases

ProteinModelPortaliQ62805.
SMRiQ62805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiQ62805.
KOiK04230.
OMAiKQVFKCH.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ62805.
TreeFamiTF315737.

Family and domain databases

CDDicd15098. 7tmA_Gal1_R. 1 hit.
InterProiView protein in InterPro
IPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAPVNLSE GNGSDPEPPA EPRPLFGIGV ENFITLVVFG LIFAMGVLGN
60 70 80 90 100
SLVITVLARS KPGKPRSTTN LFILNLSIAD LAYLLFCIPF QATVYALPTW
110 120 130 140 150
VLGAFICKFI HYFFTVSMLV SIFTLAAMSV DRYVAIVHSR RSSSLRVSRN
160 170 180 190 200
ALLGVGFIWA LSIAMASPVA YYQRLFHRDS NQTFCWEHWP NQLHKKAYVV
210 220 230 240 250
CTFVFGYLLP LLLICFCYAK VLNHLHKKLK NMSKKSEASK KKTAQTVLVV
260 270 280 290 300
VVVFGISWLP HHVIHLWAEF GAFPLTPASF FFRITAHCLA YSNSSVNPII
310 320 330 340
YAFLSENFRK AYKQVFKCRV CNESPHGDAK EKNRIDTPPS TNCTHV
Length:346
Mass (Da):38,862
Last modified:November 1, 1997 - v1
Checksum:i789FFBE40D1D3805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30290 mRNA. Translation: AAC52438.1.
RefSeqiNP_037090.2. NM_012958.3.

Genome annotation databases

EnsembliENSRNOT00000022401; ENSRNOP00000022400; ENSRNOG00000016654.
GeneIDi50577.
KEGGirno:50577.

Similar proteinsi

Entry informationi

Entry nameiGALR1_RAT
AccessioniPrimary (citable) accession number: Q62805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families