Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62805

- GALR1_RAT

UniProt

Q62805 - GALR1_RAT

Protein

Galanin receptor type 1

Gene

Galr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. galanin receptor activity Source: RGD
    2. neuropeptide binding Source: RGD
    3. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
    2. G-protein coupled receptor signaling pathway Source: RGD
    3. negative regulation of adenylate cyclase activity Source: InterPro
    4. neuropeptide signaling pathway Source: GOC
    5. positive regulation of cytosolic calcium ion concentration Source: InterPro
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 1
    Short name:
    GAL1-R
    Short name:
    GALR-1
    Gene namesi
    Name:Galr1
    Synonyms:Galnr, Galnr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi2656. Galr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Galanin receptor type 1PRO_0000069465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 185PROSITE-ProRule annotation
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Lipidationi318 – 3181S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ62805.

    PTM databases

    PhosphoSiteiQ62805.

    Expressioni

    Tissue specificityi

    Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.

    Gene expression databases

    GenevestigatoriQ62805.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022400.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62805.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 6915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 15020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19625ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24629CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 2692ExtracellularSequence Analysis
    Topological domaini291 – 34656CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    GeneTreeiENSGT00620000087530.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiQ62805.
    KOiK04230.
    OMAiPVAYHQG.
    OrthoDBiEOG7327PK.
    PhylomeDBiQ62805.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62805-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELAPVNLSE GNGSDPEPPA EPRPLFGIGV ENFITLVVFG LIFAMGVLGN    50
    SLVITVLARS KPGKPRSTTN LFILNLSIAD LAYLLFCIPF QATVYALPTW 100
    VLGAFICKFI HYFFTVSMLV SIFTLAAMSV DRYVAIVHSR RSSSLRVSRN 150
    ALLGVGFIWA LSIAMASPVA YYQRLFHRDS NQTFCWEHWP NQLHKKAYVV 200
    CTFVFGYLLP LLLICFCYAK VLNHLHKKLK NMSKKSEASK KKTAQTVLVV 250
    VVVFGISWLP HHVIHLWAEF GAFPLTPASF FFRITAHCLA YSNSSVNPII 300
    YAFLSENFRK AYKQVFKCRV CNESPHGDAK EKNRIDTPPS TNCTHV 346
    Length:346
    Mass (Da):38,862
    Last modified:November 1, 1997 - v1
    Checksum:i789FFBE40D1D3805
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30290 mRNA. Translation: AAC52438.1.
    RefSeqiNP_037090.2. NM_012958.2.
    UniGeneiRn.10213.

    Genome annotation databases

    EnsembliENSRNOT00000022401; ENSRNOP00000022400; ENSRNOG00000016654.
    GeneIDi50577.
    KEGGirno:50577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30290 mRNA. Translation: AAC52438.1 .
    RefSeqi NP_037090.2. NM_012958.2.
    UniGenei Rn.10213.

    3D structure databases

    ProteinModelPortali Q62805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022400.

    Chemistry

    BindingDBi Q62805.
    ChEMBLi CHEMBL5504.
    GuidetoPHARMACOLOGYi 243.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q62805.

    Proteomic databases

    PRIDEi Q62805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022401 ; ENSRNOP00000022400 ; ENSRNOG00000016654 .
    GeneIDi 50577.
    KEGGi rno:50577.

    Organism-specific databases

    CTDi 2587.
    RGDi 2656. Galr1.

    Phylogenomic databases

    eggNOGi NOG320953.
    GeneTreei ENSGT00620000087530.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi Q62805.
    KOi K04230.
    OMAi PVAYHQG.
    OrthoDBi EOG7327PK.
    PhylomeDBi Q62805.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 610426.
    PROi Q62805.

    Gene expression databases

    Genevestigatori Q62805.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells."
      Parker E.M., Izzarelli D.G., Nowak H.P., Mahle C.D., Iben L.G., Wang J., Goldstein M.E.
      Brain Res. Mol. Brain Res. 34:179-189(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Insulinoma.

    Entry informationi

    Entry nameiGALR1_RAT
    AccessioniPrimary (citable) accession number: Q62805
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3