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Q62805

- GALR1_RAT

UniProt

Q62805 - GALR1_RAT

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Protein

Galanin receptor type 1

Gene

Galr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. galanin receptor activity Source: RGD
  2. neuropeptide binding Source: RGD
  3. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  2. G-protein coupled receptor signaling pathway Source: RGD
  3. negative regulation of adenylate cyclase activity Source: InterPro
  4. neuropeptide signaling pathway Source: GOC
  5. positive regulation of cortisol secretion Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration Source: InterPro
  7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi2656. Galr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 6915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 10818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 15020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19625ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 24629CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 2692ExtracellularSequence Analysis
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 34656CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Galanin receptor type 1PRO_0000069465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 185PROSITE-ProRule annotation
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Lipidationi318 – 3181S-palmitoyl cysteineBy similarity

Post-translational modificationi

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ62805.

PTM databases

PhosphoSiteiQ62805.

Expressioni

Tissue specificityi

Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.

Gene expression databases

ExpressionAtlasiQ62805. differential.
GenevestigatoriQ62805.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022400.

Structurei

3D structure databases

ProteinModelPortaliQ62805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiQ62805.
KOiK04230.
OMAiPVAYHQG.
OrthoDBiEOG7327PK.
PhylomeDBiQ62805.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62805-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELAPVNLSE GNGSDPEPPA EPRPLFGIGV ENFITLVVFG LIFAMGVLGN
60 70 80 90 100
SLVITVLARS KPGKPRSTTN LFILNLSIAD LAYLLFCIPF QATVYALPTW
110 120 130 140 150
VLGAFICKFI HYFFTVSMLV SIFTLAAMSV DRYVAIVHSR RSSSLRVSRN
160 170 180 190 200
ALLGVGFIWA LSIAMASPVA YYQRLFHRDS NQTFCWEHWP NQLHKKAYVV
210 220 230 240 250
CTFVFGYLLP LLLICFCYAK VLNHLHKKLK NMSKKSEASK KKTAQTVLVV
260 270 280 290 300
VVVFGISWLP HHVIHLWAEF GAFPLTPASF FFRITAHCLA YSNSSVNPII
310 320 330 340
YAFLSENFRK AYKQVFKCRV CNESPHGDAK EKNRIDTPPS TNCTHV
Length:346
Mass (Da):38,862
Last modified:November 1, 1997 - v1
Checksum:i789FFBE40D1D3805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30290 mRNA. Translation: AAC52438.1.
RefSeqiNP_037090.2. NM_012958.2.
UniGeneiRn.10213.

Genome annotation databases

EnsembliENSRNOT00000022401; ENSRNOP00000022400; ENSRNOG00000016654.
GeneIDi50577.
KEGGirno:50577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30290 mRNA. Translation: AAC52438.1 .
RefSeqi NP_037090.2. NM_012958.2.
UniGenei Rn.10213.

3D structure databases

ProteinModelPortali Q62805.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022400.

Chemistry

BindingDBi Q62805.
ChEMBLi CHEMBL5504.
GuidetoPHARMACOLOGYi 243.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q62805.

Proteomic databases

PRIDEi Q62805.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022401 ; ENSRNOP00000022400 ; ENSRNOG00000016654 .
GeneIDi 50577.
KEGGi rno:50577.

Organism-specific databases

CTDi 2587.
RGDi 2656. Galr1.

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi Q62805.
KOi K04230.
OMAi PVAYHQG.
OrthoDBi EOG7327PK.
PhylomeDBi Q62805.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 610426.
PROi Q62805.

Gene expression databases

ExpressionAtlasi Q62805. differential.
Genevestigatori Q62805.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells."
    Parker E.M., Izzarelli D.G., Nowak H.P., Mahle C.D., Iben L.G., Wang J., Goldstein M.E.
    Brain Res. Mol. Brain Res. 34:179-189(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.

Entry informationi

Entry nameiGALR1_RAT
AccessioniPrimary (citable) accession number: Q62805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3