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Q62805 (GALR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 1

Short name=GAL1-R
Short name=GALR-1
Gene names
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.

Post-translational modification

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Galanin receptor type 1
PRO_0000069465

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Name=1; Potential
Topological domain55 – 6915Cytoplasmic Potential
Transmembrane70 – 9021Helical; Name=2; Potential
Topological domain91 – 10818Extracellular Potential
Transmembrane109 – 13022Helical; Name=3; Potential
Topological domain131 – 15020Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 19625Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 24629Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 2692Extracellular Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 34656Cytoplasmic Potential

Amino acid modifications

Lipidation3181S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62805 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 789FFBE40D1D3805

FASTA34638,862
        10         20         30         40         50         60 
MELAPVNLSE GNGSDPEPPA EPRPLFGIGV ENFITLVVFG LIFAMGVLGN SLVITVLARS 

        70         80         90        100        110        120 
KPGKPRSTTN LFILNLSIAD LAYLLFCIPF QATVYALPTW VLGAFICKFI HYFFTVSMLV 

       130        140        150        160        170        180 
SIFTLAAMSV DRYVAIVHSR RSSSLRVSRN ALLGVGFIWA LSIAMASPVA YYQRLFHRDS 

       190        200        210        220        230        240 
NQTFCWEHWP NQLHKKAYVV CTFVFGYLLP LLLICFCYAK VLNHLHKKLK NMSKKSEASK 

       250        260        270        280        290        300 
KKTAQTVLVV VVVFGISWLP HHVIHLWAEF GAFPLTPASF FFRITAHCLA YSNSSVNPII 

       310        320        330        340 
YAFLSENFRK AYKQVFKCRV CNESPHGDAK EKNRIDTPPS TNCTHV 

« Hide

References

[1]"Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells."
Parker E.M., Izzarelli D.G., Nowak H.P., Mahle C.D., Iben L.G., Wang J., Goldstein M.E.
Brain Res. Mol. Brain Res. 34:179-189(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Insulinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30290 mRNA. Translation: AAC52438.1.
RefSeqNP_037090.2. NM_012958.2.
UniGeneRn.10213.

3D structure databases

ProteinModelPortalQ62805.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000022400.

Chemistry

BindingDBQ62805.
ChEMBLCHEMBL5504.
GuidetoPHARMACOLOGY243.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ62805.

Proteomic databases

PRIDEQ62805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022401; ENSRNOP00000022400; ENSRNOG00000016654.
GeneID50577.
KEGGrno:50577.

Organism-specific databases

CTD2587.
RGD2656. Galr1.

Phylogenomic databases

eggNOGNOG320953.
GeneTreeENSGT00620000087530.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidQ62805.
KOK04230.
OMAPVAYHQG.
OrthoDBEOG7327PK.
PhylomeDBQ62805.
TreeFamTF315737.

Gene expression databases

GenevestigatorQ62805.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610426.
PROQ62805.

Entry information

Entry nameGALR1_RAT
AccessionPrimary (citable) accession number: Q62805
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries