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Q62799

- ERBB3_RAT

UniProt

Q62799 - ERBB3_RAT

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Protein

Receptor tyrosine-protein kinase erbB-3

Gene
Erbb3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei740 – 7401ATP By similarity
Active sitei832 – 8321Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi713 – 7219ATP By similarity
Nucleotide bindingi786 – 7883ATP By similarity
Nucleotide bindingi832 – 8376ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. neuregulin binding Source: RGD
  3. neuregulin receptor activity Source: RGD
  4. receptor signaling protein tyrosine kinase activity Source: InterPro
  5. transmembrane receptor protein tyrosine kinase activity Source: RGD

GO - Biological processi

  1. axonogenesis Source: RGD
  2. cellular response to insulin stimulus Source: RGD
  3. circadian rhythm Source: RGD
  4. epidermal growth factor receptor signaling pathway Source: RGD
  5. mammary gland involution Source: RGD
  6. odontogenesis Source: RGD
  7. peptidyl-tyrosine phosphorylation Source: GOC
  8. positive regulation of glucose import Source: RGD
  9. response to drug Source: RGD
  10. response to wounding Source: RGD
  11. skeletal muscle tissue development Source: RGD
  12. tongue development Source: RGD
  13. transmembrane receptor protein tyrosine kinase signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene-like protein c-ErbB-3
Gene namesi
Name:Erbb3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69323. Erbb3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 643624Extracellular Reviewed predictionAdd
BLAST
Transmembranei644 – 66219Helical; Reviewed predictionAdd
BLAST
Topological domaini663 – 1339677Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. nucleus Source: RGD
  3. postsynaptic membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 13391320Receptor tyrosine-protein kinase erbB-3PRO_0000016673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi186 ↔ 194 By similarity
Disulfide bondi190 ↔ 202 By similarity
Disulfide bondi210 ↔ 218 By similarity
Disulfide bondi214 ↔ 226 By similarity
Disulfide bondi227 ↔ 235 By similarity
Disulfide bondi231 ↔ 243 By similarity
Disulfide bondi246 ↔ 255 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi259 ↔ 286 By similarity
Disulfide bondi290 ↔ 301 By similarity
Disulfide bondi305 ↔ 320 By similarity
Disulfide bondi323 ↔ 327 By similarity
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi500 ↔ 509 By similarity
Disulfide bondi504 ↔ 517 By similarity
Disulfide bondi520 ↔ 529 By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi533 ↔ 549 By similarity
Disulfide bondi556 ↔ 573 By similarity
Glycosylationi566 – 5661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi576 ↔ 585 By similarity
Disulfide bondi589 ↔ 610 By similarity
Disulfide bondi613 ↔ 621 By similarity
Glycosylationi616 – 6161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi617 ↔ 629 By similarity

Post-translational modificationi

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62799.
PRIDEiQ62799.

PTM databases

PhosphoSiteiQ62799.

Expressioni

Gene expression databases

GenevestigatoriQ62799.

Interactioni

Subunit structurei

Monomer and homodimer. Heterodimer with each of the other ERBB receptors Reviewed prediction. Interacts with CSPG5, PA2G4, GRB7, MYOC and MUC1 By similarity.

Protein-protein interaction databases

BioGridi248136. 2 interactions.
MINTiMINT-132305.
STRINGi10116.ENSRNOP00000006796.

Structurei

3D structure databases

ProteinModelPortaliQ62799.
SMRiQ62799. Positions 25-630, 665-977.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini707 – 964258Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 25977Cys-richAdd
BLAST

Domaini

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
InParanoidiQ62799.
KOiK05084.
PhylomeDBiQ62799.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62799-1 [UniParc]FASTAAdd to Basket

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MRATGTLQVL CFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY     50
KLYEKCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP 100
NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLKFTQLT EILSGGVYIE 150
KNDKLCHMDT IDWRDIVRVR GAEIVVKNNG ANCPPCHEVC KGRCWGPGPD 200
DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD TDCFACRRFN 250
DSGACVPRCP EPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTF 300
CVRACPPDKM EVDKHGLKMC EPCGGLCPKA CEGTGSGSRY QTVDSSNIDG 350
FVNCTKILGN LDFLITGLNV DPWHKIPALD PEKLNVFRTV REITGYLNIQ 400
SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS 450
AGRVYISANQ QLCYHHSLNW TRLLRGPSEE RLDIKYDRPL GECLAEGKVC 500
DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNFLQGEP REFVHEAQCF 550
SCHPECLPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600
YKYPDAQNEC RPCHENCTQG CNGPELQDCL GQAEVLMSKP HLVIAVTVGL 650
AVILMILGGS FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR 700
IFKETELRKL KVLGSGVFGT VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS 750
FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS LQLVTQYLPL GSLLDHVKQH 800
RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML KSPSQVQVAD 850
FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE 950
NIRPTFKELA NEFTRMARDP PRYLVIKRAS GPGTPPAAEP SVLTTKELQE 1000
AELEPELDLD LDLEAEEEGL ATSLGSALSL PTGTLTRPRG SQSLLSPSSG 1050
YMPMNQSSLG EACLDSAVLG GREQFSRPIS LHPIPRGRPA SESSEGHVTG 1100
SEAELQEKVS VCRSRSRSRS PRPRGDSAYH SQRHSLLTPV TPLSPPGLEE 1150
EDGNGYVMPD THLRGASSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200
RRGSPPRPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG 1250
TTPDEDYEYM NRRRGAGGAG GDYAAMGACP AAEQGYEEMR AFQGPGHHAP 1300
HVRYARLKTL RSLEATDSAF DNPDYWHSRL FPKANAQRT 1339
Length:1,339
Mass (Da):147,546
Last modified:June 6, 2002 - v3
Checksum:i0AA5F2402BBFDF1E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1028 – 10281L → P in AAC53050. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29339 mRNA. Translation: AAC28498.2.
U52530 mRNA. Translation: AAC53050.1.
PIRiJC4387.
RefSeqiNP_058914.2. NM_017218.3.
UniGeneiRn.10228.

Genome annotation databases

GeneIDi29496.
KEGGirno:29496.
UCSCiRGD:69323. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29339 mRNA. Translation: AAC28498.2 .
U52530 mRNA. Translation: AAC53050.1 .
PIRi JC4387.
RefSeqi NP_058914.2. NM_017218.3.
UniGenei Rn.10228.

3D structure databases

ProteinModelPortali Q62799.
SMRi Q62799. Positions 25-630, 665-977.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248136. 2 interactions.
MINTi MINT-132305.
STRINGi 10116.ENSRNOP00000006796.

PTM databases

PhosphoSitei Q62799.

Proteomic databases

PaxDbi Q62799.
PRIDEi Q62799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29496.
KEGGi rno:29496.
UCSCi RGD:69323. rat.

Organism-specific databases

CTDi 2065.
RGDi 69323. Erbb3.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000230982.
HOVERGENi HBG000490.
InParanoidi Q62799.
KOi K05084.
PhylomeDBi Q62799.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 5301.

Miscellaneous databases

NextBioi 609384.
PROi Q62799.

Gene expression databases

Genevestigatori Q62799.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein."
    Hellyer N.J., Kim H.-H., Greaves C.H., Sierke S.L., Koland J.G.
    Gene 165:279-284(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. Hellyer N.J., Koland J.G.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 85; 513 AND 565.
  3. "Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration."
    Carroll S.L., Miller M.L., Frohnert P.W., Kim S.S., Corbett J.A.
    J. Neurosci. 17:1642-1659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 922-1097.
    Strain: Sprague-Dawley.
    Tissue: Sciatic nerve.

Entry informationi

Entry nameiERBB3_RAT
AccessioniPrimary (citable) accession number: Q62799
Secondary accession number(s): Q62955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi