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Q62799 (ERBB3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor tyrosine-protein kinase erbB-3

EC=2.7.10.1
Alternative name(s):
Proto-oncogene-like protein c-ErbB-3
Gene names
Name:Erbb3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Monomer and homodimer. Heterodimer with each of the other ERBB receptors Potential. Interacts with CSPG5, PA2G4, GRB7, MYOC and MUC1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Post-translational modification

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxonogenesis

Inferred from expression pattern Ref.3. Source: RGD

cellular response to insulin stimulus

Inferred from expression pattern PubMed 9389501. Source: RGD

circadian rhythm

Inferred from expression pattern PubMed 12454858. Source: RGD

epidermal growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 14711829. Source: RGD

mammary gland involution

Inferred from expression pattern PubMed 10653587. Source: RGD

odontogenesis

Inferred from expression pattern PubMed 12112465. Source: RGD

peptidyl-tyrosine phosphorylation

Traceable author statement Ref.3. Source: GOC

positive regulation of glucose import

Inferred from mutant phenotype PubMed 14711829. Source: RGD

response to drug

Inferred from expression pattern PubMed 18184445. Source: RGD

response to wounding

Inferred from expression pattern Ref.3. Source: RGD

skeletal muscle tissue development

Inferred from expression pattern PubMed 8846777. Source: RGD

tongue development

Inferred from expression pattern PubMed 10908606. Source: RGD

transmembrane receptor protein tyrosine kinase signaling pathway

Traceable author statement Ref.3. Source: RGD

   Cellular_componentintegral component of membrane

Traceable author statement Ref.3. Source: RGD

nucleus

Inferred from direct assay PubMed 17553674. Source: RGD

postsynaptic membrane

Inferred from direct assay PubMed 7589796. Source: RGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

neuregulin binding

Inferred from mutant phenotype PubMed 14711829. Source: RGD

neuregulin receptor activity

Inferred from mutant phenotype PubMed 14711829. Source: RGD

receptor signaling protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

transmembrane receptor protein tyrosine kinase activity

Traceable author statement Ref.3. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 13391320Receptor tyrosine-protein kinase erbB-3
PRO_0000016673

Regions

Topological domain20 – 643624Extracellular Potential
Transmembrane644 – 66219Helical; Potential
Topological domain663 – 1339677Cytoplasmic Potential
Domain707 – 964258Protein kinase
Nucleotide binding713 – 7219ATP By similarity
Nucleotide binding786 – 7883ATP By similarity
Nucleotide binding832 – 8376ATP By similarity
Compositional bias183 – 25977Cys-rich

Sites

Active site8321Proton acceptor By similarity
Binding site7401ATP By similarity

Amino acid modifications

Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential
Glycosylation6161N-linked (GlcNAc...) Potential
Disulfide bond186 ↔ 194 By similarity
Disulfide bond190 ↔ 202 By similarity
Disulfide bond210 ↔ 218 By similarity
Disulfide bond214 ↔ 226 By similarity
Disulfide bond227 ↔ 235 By similarity
Disulfide bond231 ↔ 243 By similarity
Disulfide bond246 ↔ 255 By similarity
Disulfide bond259 ↔ 286 By similarity
Disulfide bond290 ↔ 301 By similarity
Disulfide bond305 ↔ 320 By similarity
Disulfide bond323 ↔ 327 By similarity
Disulfide bond500 ↔ 509 By similarity
Disulfide bond504 ↔ 517 By similarity
Disulfide bond520 ↔ 529 By similarity
Disulfide bond533 ↔ 549 By similarity
Disulfide bond556 ↔ 573 By similarity
Disulfide bond576 ↔ 585 By similarity
Disulfide bond589 ↔ 610 By similarity
Disulfide bond613 ↔ 621 By similarity
Disulfide bond617 ↔ 629 By similarity

Experimental info

Sequence conflict10281L → P in AAC53050. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q62799 [UniParc].

Last modified June 6, 2002. Version 3.
Checksum: 0AA5F2402BBFDF1E

FASTA1,339147,546
        10         20         30         40         50         60 
MRATGTLQVL CFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 

        70         80         90        100        110        120 
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 

       130        140        150        160        170        180 
LNYNTNSSHA LRQLKFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRVR GAEIVVKNNG 

       190        200        210        220        230        240 
ANCPPCHEVC KGRCWGPGPD DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 

       250        260        270        280        290        300 
TDCFACRRFN DSGACVPRCP EPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTF 

       310        320        330        340        350        360 
CVRACPPDKM EVDKHGLKMC EPCGGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 

       370        380        390        400        410        420 
LDFLITGLNV DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 

       430        440        450        460        470        480 
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPSEE 

       490        500        510        520        530        540 
RLDIKYDRPL GECLAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNFLQGEP 

       550        560        570        580        590        600 
REFVHEAQCF SCHPECLPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 

       610        620        630        640        650        660 
YKYPDAQNEC RPCHENCTQG CNGPELQDCL GQAEVLMSKP HLVIAVTVGL AVILMILGGS 

       670        680        690        700        710        720 
FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 

       730        740        750        760        770        780 
VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 

       790        800        810        820        830        840 
LQLVTQYLPL GSLLDHVKQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 

       850        860        870        880        890        900 
KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 

       910        920        930        940        950        960 
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 

       970        980        990       1000       1010       1020 
NEFTRMARDP PRYLVIKRAS GPGTPPAAEP SVLTTKELQE AELEPELDLD LDLEAEEEGL 

      1030       1040       1050       1060       1070       1080 
ATSLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSSLG EACLDSAVLG GREQFSRPIS 

      1090       1100       1110       1120       1130       1140 
LHPIPRGRPA SESSEGHVTG SEAELQEKVS VCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 

      1150       1160       1170       1180       1190       1200 
TPLSPPGLEE EDGNGYVMPD THLRGASSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 

      1210       1220       1230       1240       1250       1260 
RRGSPPRPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 

      1270       1280       1290       1300       1310       1320 
NRRRGAGGAG GDYAAMGACP AAEQGYEEMR AFQGPGHHAP HVRYARLKTL RSLEATDSAF 

      1330 
DNPDYWHSRL FPKANAQRT 

« Hide

References

[1]"Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein."
Hellyer N.J., Kim H.-H., Greaves C.H., Sierke S.L., Koland J.G.
Gene 165:279-284(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[2]Hellyer N.J., Koland J.G.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 85; 513 AND 565.
[3]"Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration."
Carroll S.L., Miller M.L., Frohnert P.W., Kim S.S., Corbett J.A.
J. Neurosci. 17:1642-1659(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 922-1097.
Strain: Sprague-Dawley.
Tissue: Sciatic nerve.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29339 mRNA. Translation: AAC28498.2.
U52530 mRNA. Translation: AAC53050.1.
PIRJC4387.
RefSeqNP_058914.2. NM_017218.3.
UniGeneRn.10228.

3D structure databases

ProteinModelPortalQ62799.
SMRQ62799. Positions 25-630, 665-977.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248136. 2 interactions.
MINTMINT-132305.
STRING10116.ENSRNOP00000006796.

PTM databases

PhosphoSiteQ62799.

Proteomic databases

PaxDbQ62799.
PRIDEQ62799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29496.
KEGGrno:29496.
UCSCRGD:69323. rat.

Organism-specific databases

CTD2065.
RGD69323. Erbb3.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000230982.
HOVERGENHBG000490.
InParanoidQ62799.
KOK05084.
PhylomeDBQ62799.

Enzyme and pathway databases

BRENDA2.7.10.1. 5301.

Gene expression databases

GenevestigatorQ62799.

Family and domain databases

Gene3D3.80.20.20. 2 hits.
InterProIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609384.
PROQ62799.

Entry information

Entry nameERBB3_RAT
AccessionPrimary (citable) accession number: Q62799
Secondary accession number(s): Q62955
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families