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Protein

Dorsal root ganglia homeobox protein

Gene

Drgx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 92HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal root ganglia homeobox protein
Alternative name(s):
Dorsal root ganglion 11
Homeobox protein DRG11
Paired-related homeobox protein-like 1
Gene namesi
Name:Drgx
Synonyms:Drg11, Prrxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628616. Drgx.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492581 – 263Dorsal root ganglia homeobox proteinAdd BLAST263

Proteomic databases

PaxDbiQ62798.

PTM databases

PhosphoSitePlusiQ62798.

Expressioni

Tissue specificityi

Expressed in most sensory neurons but not in autonomic neurons. Also expressed in the dorsal horn of the spinal cord.

Developmental stagei

First detected at E12.5 in the nervous system and in the dorsal root ganglia of the trunk region. By E15.5, strong expression in trunk and dorsal spinal cord and at E17.5 expression increases in the dorsal horns.

Interactioni

Subunit structurei

Interacts with RGMB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027186.

Structurei

3D structure databases

ProteinModelPortaliQ62798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 217OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG106743.
InParanoidiQ62798.
PhylomeDBiQ62798.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYFHCPPQL EGTAPFGNHS TGDFDDGFLR RKQRRNRTTF ALQQLEALEA
60 70 80 90 100
VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP
110 120 130 140 150
GAKEPMAEVT PPPVRNINSP PPGDQARGKK EALEAQQSLG RTVGPAGPFF
160 170 180 190 200
PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS
210 220 230 240 250
NRTASVAALR MKAREHSEAV LQSANLLPST SSSPGPASKQ VPPEGSQDKP
260
SPTKEQSEGE KSV
Length:263
Mass (Da):28,621
Last modified:November 1, 1996 - v1
Checksum:i195DBB44D5953D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29174 mRNA. Translation: AAA87203.1.
RefSeqiNP_665710.1. NM_145767.1.
UniGeneiRn.10189.

Genome annotation databases

GeneIDi252880.
KEGGirno:252880.
UCSCiRGD:628616. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29174 mRNA. Translation: AAA87203.1.
RefSeqiNP_665710.1. NM_145767.1.
UniGeneiRn.10189.

3D structure databases

ProteinModelPortaliQ62798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027186.

PTM databases

PhosphoSitePlusiQ62798.

Proteomic databases

PaxDbiQ62798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252880.
KEGGirno:252880.
UCSCiRGD:628616. rat.

Organism-specific databases

CTDi644168.
RGDi628616. Drgx.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG106743.
InParanoidiQ62798.
PhylomeDBiQ62798.

Miscellaneous databases

PROiQ62798.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRGX_RAT
AccessioniPrimary (citable) accession number: Q62798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.