Q62797 (Q62797_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Ptpro Ensembl ENSRNOP00000044055

Submitted name:
Protein tyrosine phosphatase D30 EMBL AAB51771.1
Submitted name:
Protein tyrosine phosphatase, receptor type, O, isoform CRA_b EMBL EDM01587.1

Gene names

Name:	Ptpro EMBL EDM01587.1 RGD 62068 Ensembl ENSRNOP00000044055
ORF Names:	rCG_30002 EMBL EDM01587.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. SAAS SAAS016130

Ontologies

Keywords
Domain	Signal EMBL AAB51771.1
Molecular function	Hydrolase Protein phosphatase SAAS SAAS016130 Receptor EMBL EDM01587.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from sequence or structural similarity. Source: UniProtKB glomerular visceral epithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB lamellipodium assembly Inferred from sequence or structural similarity. Source: UniProtKB monocyte chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glomerular filtration Inferred from mutant phenotype PubMed 19403647. Source: UniProtKB slit diaphragm assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB dendritic spine Inferred from sequence or structural similarity. Source: UniProtKB lateral plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	Wnt-protein binding Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential EMBL AAB51771.1
	Chain	30 – 1216	1187	Potential EMBL AAB51771.1		PRO_5000144620

Sequences

	Sequence		Length	Mass (Da)
	Q62797 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 665B95ABDB4A4AB0	FASTA	1,216	137,611
	10 20 30 40 50 60 MGHLPRERRG GRRLLPLLGL FVLLKIVSTF HVTVRDDNNI VVSLEASDVV SPTSVYVVRV 70 80 90 100 110 120 AGESKNYFFE FEESNGTLPP PVVFKATYHG LYYIISLVVV SGNVVTKPSR SITVLTKPLP 130 140 150 160 170 180 VTSVSIYDYK PSPETGVLFE IHYPEKYNVF SRVNISYWEG KDFRTMLYKD FLKGKTVFNH 190 200 210 220 230 240 WLPGICYSNI TFQLVSEATF NKSTLVECSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW 250 260 270 280 290 300 EEPSGSFPED SFIKPQDAIG RDRPFHFPEE TPETPASNAS SGWPDPNGTE YESTSQPYWW 310 320 330 340 350 360 DSASAAPENE EDFVSVLPAD YDTEATLGRT EKPTADPFSA FPVQMTLSWL PPKPPTAFDG 370 380 390 400 410 420 FNILIEREGN FTDYLTVDEE AHEFVAELKE PGKYRLSVTT FSSSGACETR KSQSAKSLSF 430 440 450 460 470 480 YISPTGEWIE ELTEKPQHVS VHVLSSTTAL LSWTSSQENY NSTIVSVVSL TCQKQKESQR 490 500 510 520 530 540 LEKQYCTQVN SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP 550 560 570 580 590 600 LGPTAVVLSW TRPYLGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT SSVRIANLLP 610 620 630 640 650 660 AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS WTYGDATTDL 670 680 690 700 710 720 SHSRMLHWMV VAEGRRKIKK SVTRNVMTAI LSLPPGDIYN LSVTACTERG SNTSMLRLVK 730 740 750 760 770 780 LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD FFEVLCQKLG SGHDGKLQEP VAVSSHVVTI 790 800 810 820 830 840 SSLLPATAYN CSVTSFSHDS PSVPTFIAVS TMVTEVNPNV VVISVLAILS ILLIGLLLVT 850 860 870 880 890 900 LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWRRSV FTFLTLLPSC LWTDYLLAFY 910 920 930 940 950 960 INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP 970 980 990 1000 1010 1020 LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND 1030 1040 1050 1060 1070 1080 FWKMVLQQKS RIIVMLTQCN EKRRVKCDHY WPFTEEPIAY GDITVEMVSE EEQEDWASRH 1090 1100 1110 1120 1130 1140 FRINYADEAQ DVMHFNYTAW PDHGVPPANA AESILQFVYT VRQQATKSKG PMIIHCSAGV 1150 1160 1170 1180 1190 1200 GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWLKKK 1210 QQFCISDVIY ENVSKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system." Tagawa M., Shirasawa T., Yahagi Y., Tomoda T., Kuroyanagi H., Fujimura S., Sakiyama S., Maruyama N. Biochem. J. 321:865-871(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAB51771.1. Tissue: Brain EMBL AAB51771.1.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000044055.
[3]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM01587.1.
[4]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM01587.1.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000044055.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06033972 Genomic DNA. No translation available. AABR06033973 Genomic DNA. No translation available. AABR06033974 Genomic DNA. No translation available. U28938 mRNA. Translation: AAB51771.1. CH473964 Genomic DNA. Translation: EDM01587.1.
IPI	IPI00208299.
RefSeq	NP_059032.1. NM_017336.1.
UniGene	Rn.10163.
3D structure databases
SMR	Q62797. Positions 916-1208.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231.
GeneID	50677.
KEGG	rno:50677.
Organism-specific databases
CTD	5800.
RGD	62068. Ptpro.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00700000104388.
HOGENOM	HOG000115792.
HOVERGEN	HBG053763.
InParanoid	Q62797.
KO	K01104.
OMA	FFEVFCQ.
OrthoDB	EOG4F7NJ6.
Gene expression databases
Genevestigator	Q62797.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 4 hits. SM00194. PTPc. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 6 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610510.

Entry information

Entry name

Q62797_RAT

Accession

Primary (citable) accession number: Q62797

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)