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Protein
Submitted name:

Protein tyrosine phosphatase D30

Gene

Ptpro

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase D30Imported
Submitted name:
Protein tyrosine phosphatase, receptor type, OImported
Submitted name:
Protein tyrosine phosphatase, receptor type, O, isoform CRA_bImported
Gene namesi
Name:PtproImported
ORF Names:rCG_30002Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi62068. Ptpro.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei820 – 844HelicalSequence analysisAdd BLAST25
Transmembranei880 – 901HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501050623930 – 1216Sequence analysisAdd BLAST1187

Expressioni

Gene expression databases

BgeeiENSRNOG00000006231.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044055.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 425Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini435 – 531Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini532 – 634Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini725 – 817Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini938 – 1195Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1112 – 1186TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00880000137849.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
KOiK18035.
OMAiSVTACTE.
OrthoDBiEOG091G00JF.
TreeFamiTF351926.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 5 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 4 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLPRERRG GRRLLPLLGL FVLLKIVSTF HVTVRDDNNI VVSLEASDVV
60 70 80 90 100
SPTSVYVVRV AGESKNYFFE FEESNGTLPP PVVFKATYHG LYYIISLVVV
110 120 130 140 150
SGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG KDFRTMLYKD FLKGKTVFNH WLPGICYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVECSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPQDAIG RDRPFHFPEE TPETPASNAS SGWPDPNGTE YESTSQPYWW
310 320 330 340 350
DSASAAPENE EDFVSVLPAD YDTEATLGRT EKPTADPFSA FPVQMTLSWL
360 370 380 390 400
PPKPPTAFDG FNILIEREGN FTDYLTVDEE AHEFVAELKE PGKYRLSVTT
410 420 430 440 450
FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS VHVLSSTTAL
460 470 480 490 500
LSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPVIENLV
510 520 530 540 550
PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW
560 570 580 590 600
TRPYLGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT SSVRIANLLP
610 620 630 640 650
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
660 670 680 690 700
WTYGDATTDL SHSRMLHWMV VAEGRRKIKK SVTRNVMTAI LSLPPGDIYN
710 720 730 740 750
LSVTACTERG SNTSMLRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD
760 770 780 790 800
FFEVLCQKLG SGHDGKLQEP VAVSSHVVTI SSLLPATAYN CSVTSFSHDS
810 820 830 840 850
PSVPTFIAVS TMVTEVNPNV VVISVLAILS ILLIGLLLVT LVILRKKHLQ
860 870 880 890 900
MARECGAGTF VNFASLEREG KLPYSWRRSV FTFLTLLPSC LWTDYLLAFY
910 920 930 940 950
INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL QFEELKLIGL
960 970 980 990 1000
DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG
1010 1020 1030 1040 1050
YNSPQEYIAT QGPLPETRND FWKMVLQQKS RIIVMLTQCN EKRRVKCDHY
1060 1070 1080 1090 1100
WPFTEEPIAY GDITVEMVSE EEQEDWASRH FRINYADEAQ DVMHFNYTAW
1110 1120 1130 1140 1150
PDHGVPPANA AESILQFVYT VRQQATKSKG PMIIHCSAGV GRTGTFIALD
1160 1170 1180 1190 1200
RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWLKKK
1210
QQFCISDVIY ENVSKS
Length:1,216
Mass (Da):137,611
Last modified:November 1, 1996 - v1
Checksum:i665B95ABDB4A4AB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062356 Genomic DNA. No translation available.
U28938 mRNA. Translation: AAB51771.1.
CH473964 Genomic DNA. Translation: EDM01587.1.
RefSeqiNP_059032.1. NM_017336.1.
UniGeneiRn.10163.

Genome annotation databases

EnsembliENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231.
GeneIDi50677.
KEGGirno:50677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062356 Genomic DNA. No translation available.
U28938 mRNA. Translation: AAB51771.1.
CH473964 Genomic DNA. Translation: EDM01587.1.
RefSeqiNP_059032.1. NM_017336.1.
UniGeneiRn.10163.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231.
GeneIDi50677.
KEGGirno:50677.

Organism-specific databases

CTDi5800.
RGDi62068. Ptpro.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00880000137849.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
KOiK18035.
OMAiSVTACTE.
OrthoDBiEOG091G00JF.
TreeFamiTF351926.

Gene expression databases

BgeeiENSRNOG00000006231.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 5 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 4 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ62797_RAT
AccessioniPrimary (citable) accession number: Q62797
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.