UniProtKB - Q62797 (Q62797_RAT)
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Protein
Submitted name:
Protein tyrosine phosphatase D30
Gene
Ptpro
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1136 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- protein tyrosine phosphatase activity Source: RGD
- Wnt-protein binding Source: UniProtKB
GO - Biological processi
- axon guidance Source: UniProtKB
- cell morphogenesis Source: UniProtKB
- glomerular visceral epithelial cell differentiation Source: UniProtKB
- glomerulus development Source: UniProtKB
- lamellipodium assembly Source: UniProtKB
- monocyte chemotaxis Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of glomerular filtration Source: UniProtKB
- nervous system development Source: RGD
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
- regulation of glomerular filtration Source: UniProtKB
- slit diaphragm assembly Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: Protein tyrosine phosphatase D30ImportedSubmitted name: Protein tyrosine phosphatase, receptor type, OImportedSubmitted name: Protein tyrosine phosphatase, receptor type, O, isoform CRA_bImported |
Gene namesi | Name:PtproImported ORF Names:rCG_30002Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62068. Ptpro. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 820 – 844 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 880 – 901 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5014106078 | 30 – 1216 | Sequence analysisAdd BLAST | 1187 |
Interactioni
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- Wnt-protein binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044055. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 329 – 425 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 435 – 531 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 532 – 634 | Fibronectin type-IIIInterPro annotationAdd BLAST | 103 | |
Domaini | 725 – 817 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 938 – 1195 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 258 | |
Domaini | 1112 – 1186 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 75 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG0791. Eukaryota. COG5599. LUCA. |
GeneTreei | ENSGT00900000140785. |
HOGENOMi | HOG000115792. |
HOVERGENi | HBG053763. |
KOi | K18035. |
OMAi | SVTACTE. |
OrthoDBi | EOG091G00JF. |
TreeFami | TF351926. |
Family and domain databases
CDDi | cd00063. FN3. 3 hits. |
Gene3Di | 2.60.40.10. 3 hits. 3.90.190.10. 1 hit. |
InterProi | View protein in InterPro IPR003961. FN3_dom. IPR036116. FN3_sf. IPR013783. Ig-like_fold. IPR029021. Prot-tyrosine_phosphatase-like. IPR000242. PTPase_domain. IPR016130. Tyr_Pase_AS. IPR003595. Tyr_Pase_cat. IPR000387. TYR_PHOSPHATASE_dom. |
Pfami | View protein in Pfam PF00041. fn3. 2 hits. PF00102. Y_phosphatase. 1 hit. |
PRINTSi | PR00700. PRTYPHPHTASE. |
SMARTi | View protein in SMART SM00060. FN3. 4 hits. SM00194. PTPc. 1 hit. SM00404. PTPc_motif. 1 hit. |
SUPFAMi | SSF49265. SSF49265. 2 hits. SSF52799. SSF52799. 1 hit. |
PROSITEi | View protein in PROSITE PS50853. FN3. 4 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q62797-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHLPRERRG GRRLLPLLGL FVLLKIVSTF HVTVRDDNNI VVSLEASDVV
60 70 80 90 100
SPTSVYVVRV AGESKNYFFE FEESNGTLPP PVVFKATYHG LYYIISLVVV
110 120 130 140 150
SGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG KDFRTMLYKD FLKGKTVFNH WLPGICYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVECSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPQDAIG RDRPFHFPEE TPETPASNAS SGWPDPNGTE YESTSQPYWW
310 320 330 340 350
DSASAAPENE EDFVSVLPAD YDTEATLGRT EKPTADPFSA FPVQMTLSWL
360 370 380 390 400
PPKPPTAFDG FNILIEREGN FTDYLTVDEE AHEFVAELKE PGKYRLSVTT
410 420 430 440 450
FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS VHVLSSTTAL
460 470 480 490 500
LSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPVIENLV
510 520 530 540 550
PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW
560 570 580 590 600
TRPYLGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT SSVRIANLLP
610 620 630 640 650
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
660 670 680 690 700
WTYGDATTDL SHSRMLHWMV VAEGRRKIKK SVTRNVMTAI LSLPPGDIYN
710 720 730 740 750
LSVTACTERG SNTSMLRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD
760 770 780 790 800
FFEVLCQKLG SGHDGKLQEP VAVSSHVVTI SSLLPATAYN CSVTSFSHDS
810 820 830 840 850
PSVPTFIAVS TMVTEVNPNV VVISVLAILS ILLIGLLLVT LVILRKKHLQ
860 870 880 890 900
MARECGAGTF VNFASLEREG KLPYSWRRSV FTFLTLLPSC LWTDYLLAFY
910 920 930 940 950
INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL QFEELKLIGL
960 970 980 990 1000
DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG
1010 1020 1030 1040 1050
YNSPQEYIAT QGPLPETRND FWKMVLQQKS RIIVMLTQCN EKRRVKCDHY
1060 1070 1080 1090 1100
WPFTEEPIAY GDITVEMVSE EEQEDWASRH FRINYADEAQ DVMHFNYTAW
1110 1120 1130 1140 1150
PDHGVPPANA AESILQFVYT VRQQATKSKG PMIIHCSAGV GRTGTFIALD
1160 1170 1180 1190 1200
RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWLKKK
1210
QQFCISDVIY ENVSKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07062356 Genomic DNA. No translation available. U28938 mRNA. Translation: AAB51771.1. CH473964 Genomic DNA. Translation: EDM01587.1. |
RefSeqi | NP_059032.1. NM_017336.1. |
UniGenei | Rn.10163. |
Genome annotation databases
Ensembli | ENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231. |
GeneIDi | 50677. |
KEGGi | rno:50677. |
Similar proteinsi
Entry informationi
Entry namei | Q62797_RAT | |
Accessioni | Q62797Primary (citable) accession number: Q62797 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |