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Protein

Sodium-dependent phosphate transport protein 1

Gene

Slc17a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:Slc17a1
Synonyms:Npt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620099. Slc17a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Sodium-dependent phosphate transport protein 1PRO_0000220939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62795.
PRIDEiQ62795.

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061056.

Chemistry

BindingDBiQ62795.

Structurei

3D structure databases

ProteinModelPortaliQ62795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
HOVERGENiHBG008834.
InParanoidiQ62795.
PhylomeDBiQ62795.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRCLPKKV PGFCSFRYGL AILLHFCNIV IMAQRVCLNL TMVAMVNKTE
60 70 80 90 100
PPHLSNKSVA EMLDNVKNPV HSWSLDIQGL VLSSVFLGMV VIQVPVGYLS
110 120 130 140 150
GAYPMEKIIG SSLFLSSVLS LLIPPAAQVG AALVIVCRVL QGIAQGAVST
160 170 180 190 200
GQHGIWVKWA PPLERGRLTS MTLSGFVMGP FIALLVSGFI CDLLGWPMVF
210 220 230 240 250
YIFGIVGCVL SLFWFILLFD DPNNHPYMSS SEKDYITSSL MQQVHSGRQS
260 270 280 290 300
LPIKAMLKSL PLWAIILNSF AFIWSNNLLV TYTPTFISTT LHVNVRENGL
310 320 330 340 350
LSSLPYLLAY ICGIVAGQMS DFLLSRKIFS VVAVRKLFTT LGIFCPVIFV
360 370 380 390 400
VCLLYLSYNF YSTVIFLTLA NSTLSFSFCG QLINALDIAP RYYGFLKAVT
410 420 430 440 450
ALIGIFGGLI SSTLAGLILN QDPEYAWHKN FFLMAGINVT CLAFYLLFAK
460
GDIQDWAKET KTTRL
Length:465
Mass (Da):51,350
Last modified:November 1, 1997 - v1
Checksum:i28BBBF8DC5C0AC52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28504 mRNA. Translation: AAC52487.1.
UniGeneiRn.11150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28504 mRNA. Translation: AAC52487.1.
UniGeneiRn.11150.

3D structure databases

ProteinModelPortaliQ62795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061056.

Chemistry

BindingDBiQ62795.
ChEMBLiCHEMBL3398.

Proteomic databases

PaxDbiQ62795.
PRIDEiQ62795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620099. Slc17a1.

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
HOVERGENiHBG008834.
InParanoidiQ62795.
PhylomeDBiQ62795.

Miscellaneous databases

PROiQ62795.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts."
    Li H., Xie Z.
    Cell. Mol. Biol. Res. 41:451-460(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiNPT1_RAT
AccessioniPrimary (citable) accession number: Q62795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.