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Protein

Sodium-dependent phosphate transport protein 1

Gene

Slc17a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.By similarity

GO - Molecular functioni

  • phosphate ion transmembrane transporter activity Source: InterPro
  • sodium:phosphate symporter activity Source: RGD

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:Slc17a1
Synonyms:Npt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi620099 Slc17a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209391 – 465Sodium-dependent phosphate transport protein 1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62795
PRIDEiQ62795

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061056

Chemistry databases

BindingDBiQ62795

Structurei

3D structure databases

ProteinModelPortaliQ62795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
HOVERGENiHBG008834
InParanoidiQ62795
PhylomeDBiQ62795

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004745 Pi_cotranspt
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00894 2A0114euk, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q62795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENRCLPKKV PGFCSFRYGL AILLHFCNIV IMAQRVCLNL TMVAMVNKTE
60 70 80 90 100
PPHLSNKSVA EMLDNVKNPV HSWSLDIQGL VLSSVFLGMV VIQVPVGYLS
110 120 130 140 150
GAYPMEKIIG SSLFLSSVLS LLIPPAAQVG AALVIVCRVL QGIAQGAVST
160 170 180 190 200
GQHGIWVKWA PPLERGRLTS MTLSGFVMGP FIALLVSGFI CDLLGWPMVF
210 220 230 240 250
YIFGIVGCVL SLFWFILLFD DPNNHPYMSS SEKDYITSSL MQQVHSGRQS
260 270 280 290 300
LPIKAMLKSL PLWAIILNSF AFIWSNNLLV TYTPTFISTT LHVNVRENGL
310 320 330 340 350
LSSLPYLLAY ICGIVAGQMS DFLLSRKIFS VVAVRKLFTT LGIFCPVIFV
360 370 380 390 400
VCLLYLSYNF YSTVIFLTLA NSTLSFSFCG QLINALDIAP RYYGFLKAVT
410 420 430 440 450
ALIGIFGGLI SSTLAGLILN QDPEYAWHKN FFLMAGINVT CLAFYLLFAK
460
GDIQDWAKET KTTRL
Length:465
Mass (Da):51,350
Last modified:November 1, 1997 - v1
Checksum:i28BBBF8DC5C0AC52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28504 mRNA Translation: AAC52487.1
UniGeneiRn.11150

Similar proteinsi

Entry informationi

Entry nameiNPT1_RAT
AccessioniPrimary (citable) accession number: Q62795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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