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Q62789 (UD2B7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B7

Short name=UDPGT 2B7
EC=2.4.1.17
Alternative name(s):
UGT2B-RH4
Gene names
Name:Ugt2b7
Synonyms:Ugt2b8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Plays a role in steroid metabolism and is active with Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro) By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 530513UDP-glucuronosyltransferase 2B7
PRO_0000036032

Regions

Transmembrane496 – 51621Helical; Potential
Nucleotide binding374 – 3807UDP-glucuronic acid By similarity

Sites

Binding site4001UDP-glucuronic acid By similarity

Amino acid modifications

Glycosylation3161N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q62789 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 532519950C6CAEDE

FASTA53060,089
        10         20         30         40         50         60 
MPQKWISALL LLQISFCFRS GNCGKVLVWP LEYSHWMNLK IILDELVQRG HEVTVLRPSS 

        70         80         90        100        110        120 
SVSLDPKKAS GLVYETSPTT SNNDEVEKSF YPVGDMWTYD VPKYTCLRYY PSLNKMFGQF 

       130        140        150        160        170        180 
SDLWLQLCRE VVSNKELIAK LKESQFDVVL SDAVGPCGEL IAEILQLPFV YSLRFATAPG 

       190        200        210        220        230        240 
IEKYSAGQPF PPSYVPIILS GFSGQMTFME RVENMLCLLY FDSWFESFPA KDWDPFFSEI 

       250        260        270        280        290        300 
LGRPTTMVDT MKKAEIWLIR SYWDLEFPRP SLPNIEFVGG LHCQPAKPLP KEMEDFAQSS 

       310        320        330        340        350        360 
GEHGVWVFSL GSMIRNITQE RANTIASALA QIPQKVFWRF EGKKPDTLGP NTRVFKWIPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHGGANG IYESIHYGIP PMVGIPLFAE QRDNVAHMVA KGAAVSIDFH 

       430        440        450        460        470        480 
TMSSSDLLNA LKAVINNPSY KKKVMWLSAI HHDQPLKPLD RAVFWIEFVM RHKGAKHLRP 

       490        500        510        520        530 
LAHNLALVSV HSLDVIGFLL ACVLAIVLLA VKCCLFLYRF FVKVAKNKRD 

« Hide

References

[1]"A novel member of the UDPGT family is abundantly expressed in H4IIEC3 hepatoma cells."
Cohen H., Trus M., Benvenisty N., Reshef L.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hepatoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27518 mRNA. Translation: AAA86833.1.
RefSeqNP_775445.1. NM_173323.1.
UniGeneRn.11131.

3D structure databases

ProteinModelPortalQ62789.
SMRQ62789. Positions 286-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000002716.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbQ62789.
PRIDEQ62789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID286989.
KEGGrno:286989.
UCSCRGD:708417. rat.

Organism-specific databases

CTD7364.
RGD708417. Ugt2b7.

Phylogenomic databases

eggNOGCOG1819.
HOVERGENHBG004033.
InParanoidQ62789.
KOK00699.
PhylomeDBQ62789.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorQ62789.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio625257.

Entry information

Entry nameUD2B7_RAT
AccessionPrimary (citable) accession number: Q62789
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families