Reviewed, UniProtKB/Swiss-Prot Q62789 (UD2B8_RAT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B8
      Short name=UDPGT 2B8
    EC=2.4.1.17
Alternative name(s):
    UGT2B-RH4

Gene names

Name:

Ugt2b8

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	By similarity
	Chain	18 – 530	513	UDP-glucuronosyltransferase 2B8		PRO_0000036032
Regions
	Transmembrane	496 – 516	21	Potential
Amino acid modifications
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q62789-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 532519950C6CAEDE	FASTA	530	60,089
	10 20 30 40 50 60 MPQKWISALL LLQISFCFRS GNCGKVLVWP LEYSHWMNLK IILDELVQRG HEVTVLRPSS 70 80 90 100 110 120 SVSLDPKKAS GLVYETSPTT SNNDEVEKSF YPVGDMWTYD VPKYTCLRYY PSLNKMFGQF 130 140 150 160 170 180 SDLWLQLCRE VVSNKELIAK LKESQFDVVL SDAVGPCGEL IAEILQLPFV YSLRFATAPG 190 200 210 220 230 240 IEKYSAGQPF PPSYVPIILS GFSGQMTFME RVENMLCLLY FDSWFESFPA KDWDPFFSEI 250 260 270 280 290 300 LGRPTTMVDT MKKAEIWLIR SYWDLEFPRP SLPNIEFVGG LHCQPAKPLP KEMEDFAQSS 310 320 330 340 350 360 GEHGVWVFSL GSMIRNITQE RANTIASALA QIPQKVFWRF EGKKPDTLGP NTRVFKWIPQ 370 380 390 400 410 420 NDLLGHPKTK AFVTHGGANG IYESIHYGIP PMVGIPLFAE QRDNVAHMVA KGAAVSIDFH 430 440 450 460 470 480 TMSSSDLLNA LKAVINNPSY KKKVMWLSAI HHDQPLKPLD RAVFWIEFVM RHKGAKHLRP 490 500 510 520 530 LAHNLALVSV HSLDVIGFLL ACVLAIVLLA VKCCLFLYRF FVKVAKNKRD

References

[1]	"A novel member of the UDPGT family is abundantly expressed in H4IIEC3 hepatoma cells." Cohen H., Trus M., Benvenisty N., Reshef L. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U27518 mRNA. Translation: AAA86833.1.
IPI	IPI00208281.
RefSeq	NP_775445.1.
UniGene	Rn.11131
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	Q62789.
Genome annotation databases
Ensembl	ENSRNOG00000028907. Rattus norvegicus. [Contig view]
GeneID	286989.
KEGG	rno:286989.
Organism-specific databases
RGD	708417. LOC286989.
Phylogenomic databases
HOVERGEN	Q62789.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	Q62789.
GermOnline	ENSRNOG00000028907. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	625257.

Entry information

Entry name

UD2B8_RAT

Accession

Primary (citable) accession number: Q62789

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)