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Q62789

- UD2B7_RAT

UniProt

Q62789 - UD2B7_RAT

Protein

UDP-glucuronosyltransferase 2B7

Gene

Ugt2b7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Plays a role in steroid metabolism and is active with Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro) By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei400 – 4001UDP-glucuronic acidBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi374 – 3807UDP-glucuronic acidBy similarity

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. androgen metabolic process Source: UniProtKB
    2. cellular glucuronidation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B7 (EC:2.4.1.17)
    Short name:
    UDPGT 2B7
    Alternative name(s):
    UGT2B-RH4
    Gene namesi
    Name:Ugt2b7
    Synonyms:Ugt2b8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708417. Ugt2b7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 530513UDP-glucuronosyltransferase 2B7PRO_0000036032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ62789.
    PRIDEiQ62789.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62789.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002716.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62789.
    SMRiQ62789. Positions 286-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOVERGENiHBG004033.
    InParanoidiQ62789.
    KOiK00699.
    PhylomeDBiQ62789.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62789-1 [UniParc]FASTAAdd to Basket

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    MPQKWISALL LLQISFCFRS GNCGKVLVWP LEYSHWMNLK IILDELVQRG    50
    HEVTVLRPSS SVSLDPKKAS GLVYETSPTT SNNDEVEKSF YPVGDMWTYD 100
    VPKYTCLRYY PSLNKMFGQF SDLWLQLCRE VVSNKELIAK LKESQFDVVL 150
    SDAVGPCGEL IAEILQLPFV YSLRFATAPG IEKYSAGQPF PPSYVPIILS 200
    GFSGQMTFME RVENMLCLLY FDSWFESFPA KDWDPFFSEI LGRPTTMVDT 250
    MKKAEIWLIR SYWDLEFPRP SLPNIEFVGG LHCQPAKPLP KEMEDFAQSS 300
    GEHGVWVFSL GSMIRNITQE RANTIASALA QIPQKVFWRF EGKKPDTLGP 350
    NTRVFKWIPQ NDLLGHPKTK AFVTHGGANG IYESIHYGIP PMVGIPLFAE 400
    QRDNVAHMVA KGAAVSIDFH TMSSSDLLNA LKAVINNPSY KKKVMWLSAI 450
    HHDQPLKPLD RAVFWIEFVM RHKGAKHLRP LAHNLALVSV HSLDVIGFLL 500
    ACVLAIVLLA VKCCLFLYRF FVKVAKNKRD 530
    Length:530
    Mass (Da):60,089
    Last modified:November 1, 1996 - v1
    Checksum:i532519950C6CAEDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27518 mRNA. Translation: AAA86833.1.
    RefSeqiNP_775445.1. NM_173323.1.
    UniGeneiRn.11131.

    Genome annotation databases

    GeneIDi286989.
    KEGGirno:286989.
    UCSCiRGD:708417. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27518 mRNA. Translation: AAA86833.1 .
    RefSeqi NP_775445.1. NM_173323.1.
    UniGenei Rn.11131.

    3D structure databases

    ProteinModelPortali Q62789.
    SMRi Q62789. Positions 286-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002716.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q62789.
    PRIDEi Q62789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286989.
    KEGGi rno:286989.
    UCSCi RGD:708417. rat.

    Organism-specific databases

    CTDi 7364.
    RGDi 708417. Ugt2b7.

    Phylogenomic databases

    eggNOGi COG1819.
    HOVERGENi HBG004033.
    InParanoidi Q62789.
    KOi K00699.
    PhylomeDBi Q62789.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Miscellaneous databases

    NextBioi 625257.

    Gene expression databases

    Genevestigatori Q62789.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel member of the UDPGT family is abundantly expressed in H4IIEC3 hepatoma cells."
      Cohen H., Trus M., Benvenisty N., Reshef L.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hepatoma.

    Entry informationi

    Entry nameiUD2B7_RAT
    AccessioniPrimary (citable) accession number: Q62789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3