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Protein

UDP-glucuronosyltransferase 2B7

Gene

Ugt2b7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Plays a role in steroid metabolism and is active with Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro) (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei400UDP-glucuronic acidBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 380UDP-glucuronic acidBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B7 (EC:2.4.1.17)
Short name:
UDPGT 2B7
Alternative name(s):
UGT2B-RH4
Gene namesi
Name:Ugt2b7
Synonyms:Ugt2b8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708417. Ugt2b7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000003603218 – 530UDP-glucuronosyltransferase 2B7Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ62789.

PTM databases

PhosphoSitePlusiQ62789.

Structurei

3D structure databases

ProteinModelPortaliQ62789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ62789.
KOiK00699.
PhylomeDBiQ62789.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQKWISALL LLQISFCFRS GNCGKVLVWP LEYSHWMNLK IILDELVQRG
60 70 80 90 100
HEVTVLRPSS SVSLDPKKAS GLVYETSPTT SNNDEVEKSF YPVGDMWTYD
110 120 130 140 150
VPKYTCLRYY PSLNKMFGQF SDLWLQLCRE VVSNKELIAK LKESQFDVVL
160 170 180 190 200
SDAVGPCGEL IAEILQLPFV YSLRFATAPG IEKYSAGQPF PPSYVPIILS
210 220 230 240 250
GFSGQMTFME RVENMLCLLY FDSWFESFPA KDWDPFFSEI LGRPTTMVDT
260 270 280 290 300
MKKAEIWLIR SYWDLEFPRP SLPNIEFVGG LHCQPAKPLP KEMEDFAQSS
310 320 330 340 350
GEHGVWVFSL GSMIRNITQE RANTIASALA QIPQKVFWRF EGKKPDTLGP
360 370 380 390 400
NTRVFKWIPQ NDLLGHPKTK AFVTHGGANG IYESIHYGIP PMVGIPLFAE
410 420 430 440 450
QRDNVAHMVA KGAAVSIDFH TMSSSDLLNA LKAVINNPSY KKKVMWLSAI
460 470 480 490 500
HHDQPLKPLD RAVFWIEFVM RHKGAKHLRP LAHNLALVSV HSLDVIGFLL
510 520 530
ACVLAIVLLA VKCCLFLYRF FVKVAKNKRD
Length:530
Mass (Da):60,089
Last modified:November 1, 1996 - v1
Checksum:i532519950C6CAEDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27518 mRNA. Translation: AAA86833.1.
RefSeqiNP_775445.1. NM_173323.1.
UniGeneiRn.11131.

Genome annotation databases

GeneIDi286989.
KEGGirno:286989.
UCSCiRGD:708417. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27518 mRNA. Translation: AAA86833.1.
RefSeqiNP_775445.1. NM_173323.1.
UniGeneiRn.11131.

3D structure databases

ProteinModelPortaliQ62789.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitePlusiQ62789.

Proteomic databases

PRIDEiQ62789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286989.
KEGGirno:286989.
UCSCiRGD:708417. rat.

Organism-specific databases

CTDi7364.
RGDi708417. Ugt2b7.

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiQ62789.
KOiK00699.
PhylomeDBiQ62789.

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Miscellaneous databases

PROiQ62789.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD2B7_RAT
AccessioniPrimary (citable) accession number: Q62789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.