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Q62789

- UD2B7_RAT

UniProt

Q62789 - UD2B7_RAT

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Protein

UDP-glucuronosyltransferase 2B7

Gene

Ugt2b7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Plays a role in steroid metabolism and is active with Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro) (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei400 – 4001UDP-glucuronic acidBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi374 – 3807UDP-glucuronic acidBy similarity

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. androgen metabolic process Source: UniProtKB
  2. cellular glucuronidation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B7 (EC:2.4.1.17)
Short name:
UDPGT 2B7
Alternative name(s):
UGT2B-RH4
Gene namesi
Name:Ugt2b7
Synonyms:Ugt2b8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708417. Ugt2b7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei496 – 51621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 530513UDP-glucuronosyltransferase 2B7PRO_0000036032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62789.
PRIDEiQ62789.

Expressioni

Gene expression databases

GenevestigatoriQ62789.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002716.

Structurei

3D structure databases

ProteinModelPortaliQ62789.
SMRiQ62789. Positions 286-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOVERGENiHBG004033.
InParanoidiQ62789.
KOiK00699.
PhylomeDBiQ62789.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62789-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQKWISALL LLQISFCFRS GNCGKVLVWP LEYSHWMNLK IILDELVQRG
60 70 80 90 100
HEVTVLRPSS SVSLDPKKAS GLVYETSPTT SNNDEVEKSF YPVGDMWTYD
110 120 130 140 150
VPKYTCLRYY PSLNKMFGQF SDLWLQLCRE VVSNKELIAK LKESQFDVVL
160 170 180 190 200
SDAVGPCGEL IAEILQLPFV YSLRFATAPG IEKYSAGQPF PPSYVPIILS
210 220 230 240 250
GFSGQMTFME RVENMLCLLY FDSWFESFPA KDWDPFFSEI LGRPTTMVDT
260 270 280 290 300
MKKAEIWLIR SYWDLEFPRP SLPNIEFVGG LHCQPAKPLP KEMEDFAQSS
310 320 330 340 350
GEHGVWVFSL GSMIRNITQE RANTIASALA QIPQKVFWRF EGKKPDTLGP
360 370 380 390 400
NTRVFKWIPQ NDLLGHPKTK AFVTHGGANG IYESIHYGIP PMVGIPLFAE
410 420 430 440 450
QRDNVAHMVA KGAAVSIDFH TMSSSDLLNA LKAVINNPSY KKKVMWLSAI
460 470 480 490 500
HHDQPLKPLD RAVFWIEFVM RHKGAKHLRP LAHNLALVSV HSLDVIGFLL
510 520 530
ACVLAIVLLA VKCCLFLYRF FVKVAKNKRD
Length:530
Mass (Da):60,089
Last modified:November 1, 1996 - v1
Checksum:i532519950C6CAEDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27518 mRNA. Translation: AAA86833.1.
RefSeqiNP_775445.1. NM_173323.1.
UniGeneiRn.11131.

Genome annotation databases

GeneIDi286989.
KEGGirno:286989.
UCSCiRGD:708417. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27518 mRNA. Translation: AAA86833.1 .
RefSeqi NP_775445.1. NM_173323.1.
UniGenei Rn.11131.

3D structure databases

ProteinModelPortali Q62789.
SMRi Q62789. Positions 286-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002716.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi Q62789.
PRIDEi Q62789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286989.
KEGGi rno:286989.
UCSCi RGD:708417. rat.

Organism-specific databases

CTDi 7364.
RGDi 708417. Ugt2b7.

Phylogenomic databases

eggNOGi COG1819.
HOVERGENi HBG004033.
InParanoidi Q62789.
KOi K00699.
PhylomeDBi Q62789.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Miscellaneous databases

NextBioi 625257.

Gene expression databases

Genevestigatori Q62789.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel member of the UDPGT family is abundantly expressed in H4IIEC3 hepatoma cells."
    Cohen H., Trus M., Benvenisty N., Reshef L.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatoma.

Entry informationi

Entry nameiUD2B7_RAT
AccessioniPrimary (citable) accession number: Q62789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3