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Protein
Submitted name:

Cys2/His2 zinc finger protein

Gene

Zfp111

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: RGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Cys2/His2 zinc finger proteinImported
Gene namesi
Name:Zfp111Imported
Synonyms:rKr2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620595. Zfp111.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ62788.

Expressioni

Gene expression databases

GenevisibleiQ62788. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046964.

Structurei

3D structure databases

ProteinModelPortaliQ62788.
SMRiQ62788. Positions 236-400, 459-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8679KRABInterPro annotationAdd
BLAST
Domaini210 – 23728C2H2-typeInterPro annotationAdd
BLAST
Domaini236 – 26530C2H2-typeInterPro annotationAdd
BLAST
Domaini266 – 29328C2H2-typeInterPro annotationAdd
BLAST
Domaini294 – 32128C2H2-typeInterPro annotationAdd
BLAST
Domaini322 – 34928C2H2-typeInterPro annotationAdd
BLAST
Domaini350 – 37728C2H2-typeInterPro annotationAdd
BLAST
Domaini378 – 40528C2H2-typeInterPro annotationAdd
BLAST
Domaini406 – 43328C2H2-typeInterPro annotationAdd
BLAST
Domaini434 – 46128C2H2-typeInterPro annotationAdd
BLAST
Domaini462 – 48928C2H2-typeInterPro annotationAdd
BLAST
Domaini490 – 51728C2H2-typeInterPro annotationAdd
BLAST
Domaini518 – 54528C2H2-typeInterPro annotationAdd
BLAST
Domaini546 – 57328C2H2-typeInterPro annotationAdd
BLAST
Domaini574 – 60128C2H2-typeInterPro annotationAdd
BLAST
Domaini602 – 62928C2H2-typeInterPro annotationAdd
BLAST
Domaini630 – 65728C2H2-typeInterPro annotationAdd
BLAST
Domaini658 – 68528C2H2-typeInterPro annotationAdd
BLAST
Domaini686 – 71328C2H2-typeInterPro annotationAdd
BLAST
Domaini714 – 74128C2H2-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains KRAB domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
KOiK09228.
PhylomeDBiQ62788.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLQEAVTF RDVAVVFSKE EMGLLDAAQR KLYHDVMLEN LRNLLAVGGQ
60 70 80 90 100
SPNKMKTVDA TGVRCLLLGQ LLYWEITGHD ANKLARAPEA VVHTQGKGSH
110 120 130 140 150
FLEQGHSSCH REAEEPRRPS EDDSSLDSLT RDHSSTTENQ EFLSGRAQGS
160 170 180 190 200
WCKTHLRKRQ NHQKHCLQTL MKNKPELLTQ HSPVQRTQED SRHSSSVPIQ
210 220 230 240 250
QSVHPGRKRY WCHECGKGFS QSSALQTHRR VHTGEKPCRD NSCRKSFSRS
260 270 280 290 300
SGLSIHRQVH TGERPYRCKV CGKGFLRWSH LQAHERIHTG EKPYKCGECG
310 320 330 340 350
KRFSCISNLH THQRFHSKEK PYKCDKCGKC FSLNFNLHIH QRVHTGEKPY
360 370 380 390 400
KCEECGKCFS LSFNLHSHQR VHTGEKPYKC EECGKCFSSA SSFQRHRQIH
410 420 430 440 450
IKEKTLHRDV CGKGSSRDSN LQTHQRVHIQ EKPYRCNSCG KSFRCSMDLN
460 470 480 490 500
IHRRVHTGEK PYKCEVCGKG FNYLSHLQAH EKIHADQKPY KCEYCGRRFS
510 520 530 540 550
YSSNLHTHQR VHTGEKPYKC EECGKSFSLA SSLQAHQRVQ TGKKPFKCNA
560 570 580 590 600
CQKRFSQAWN LQAHQRVHTG EKPYKCDTCG KAFGQRSSLQ IHQRIHTGEK
610 620 630 640 650
PFKCEECGKE FSLNSGLTAH RRVHTGEKPY ECTECGKGFS LASSLRTHQR
660 670 680 690 700
IHTGEKPFQC NECQKRFSQV SHLQSHQRVH TGEKPYKCDT CGKAFSQKSG
710 720 730 740
LQVHRRIHTG EKPFKCEECG KEFIWSSGLS AHRRVHTGEK TLHG
Length:744
Mass (Da):85,422
Last modified:November 1, 1996 - v1
Checksum:i02EDA246E4EEA0F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27186 mRNA. Translation: AAB60512.1.
RefSeqiNP_579857.1. NM_133323.1.
UniGeneiRn.10168.

Genome annotation databases

GeneIDi170849.
KEGGirno:170849.
UCSCiRGD:620595. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27186 mRNA. Translation: AAB60512.1.
RefSeqiNP_579857.1. NM_133323.1.
UniGeneiRn.10168.

3D structure databases

ProteinModelPortaliQ62788.
SMRiQ62788. Positions 236-400, 459-736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046964.

Proteomic databases

PaxDbiQ62788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170849.
KEGGirno:170849.
UCSCiRGD:620595. rat.

Organism-specific databases

CTDi56707.
RGDi620595. Zfp111.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
KOiK09228.
PhylomeDBiQ62788.

Gene expression databases

GenevisibleiQ62788. RN.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain."
    Pott U., Thiesen H.J., Colello R.J., Schwab M.E.
    J. Neurochem. 65:1955-1966(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ62788_RAT
AccessioniPrimary (citable) accession number: Q62788
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.