Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostaglandin F2 receptor negative regulator

Gene

Ptgfrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur.

GO - Biological processi

  • negative regulation of translation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2 receptor negative regulator
Alternative name(s):
Prostaglandin F2-alpha receptor regulatory protein
Prostaglandin F2-alpha receptor-associated protein
CD_antigen: CD315
Gene namesi
Name:Ptgfrn
Synonyms:Fprp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3437. Ptgfrn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 832811ExtracellularSequence analysisAdd
BLAST
Transmembranei833 – 85321HelicalSequence analysisAdd
BLAST
Topological domaini854 – 87926CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 879858Prostaglandin F2 receptor negative regulatorPRO_0000014764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
Modified residuei271 – 2711PhosphothreonineCombined sources
Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence analysis
Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence analysis
Glycosylationi691 – 6911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62786.
PRIDEiQ62786.

PTM databases

iPTMnetiQ62786.
PhosphoSiteiQ62786.
SwissPalmiQ62786.

Expressioni

Tissue specificityi

Reproductive tissues, lung and heart.

Interactioni

Subunit structurei

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ62786. 1 interaction.
STRINGi10116.ENSRNOP00000021162.

Structurei

3D structure databases

ProteinModelPortaliQ62786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 129108Ig-like C2-type 1Add
BLAST
Domaini149 – 268120Ig-like C2-type 2Add
BLAST
Domaini276 – 389114Ig-like C2-type 3Add
BLAST
Domaini406 – 527122Ig-like C2-type 4Add
BLAST
Domaini544 – 662119Ig-like C2-type 5Add
BLAST
Domaini688 – 813126Ig-like C2-type 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi89 – 913Cell attachment siteSequence analysis
Motifi424 – 4274Endoplasmic reticulum retention signal
Motifi703 – 7053Cell attachment siteSequence analysis

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHZG. Eukaryota.
ENOG4111FCJ. LUCA.
HOGENOMiHOG000112641.
HOVERGENiHBG031554.
InParanoidiQ62786.
KOiK06729.
PhylomeDBiQ62786.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRPAPRPLL LALLSLAVCR GRVVRVPAGT LVRVVGTELV IPCNVSDYDG
60 70 80 90 100
PSEQNFDWSF SSSGSSFVEL ASTWEVGFPA QQYRERLQRG DILLRRTAND
110 120 130 140 150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTMQVKV LADALVVGPS
160 170 180 190 200
SRPPPGLSLR EGEPFELRCI ASTTSPLHTH LALRWELHRG PVHRSILALS
210 220 230 240 250
HEGRFHPGPG YEQRYHSGDV RLDTVGSDAY RLSVARALSA DQGSYRCVVS
260 270 280 290 300
EWITEQGSWQ EIQEKAVEVA TVVIQPTALQ LAVPRTVSVT EGKDLDLSCN
310 320 330 340 350
ITTDRVDDVR PEVTWYFKKT PDTSLLASHM LARLDRDSLV HSSPHVALSH
360 370 380 390 400
VDTRSYHLLV RDVSKENSGY YLCLVALWAP GHNRSWHKVA EAMSAPSGVS
410 420 430 440 450
VTWLEPEYQV YLNASKVPGF SDDPTELQCR VIDTKRVDAG VRLTVSWYYR
460 470 480 490 500
MNRRNDDVVA SELLAVMDGD WTLRYGERSK QRAQDGEFIF SKEHTDTFSF
510 520 530 540 550
RIQRTTEEDR GSYYCVVSAW TRQRNSSWVK SKDVFSKPVN IFWASEDSVL
560 570 580 590 600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLITAE KPVGDLSSPN
610 620 630 640 650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA
660 670 680 690 700
GLYRCMVTAW SPIGGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTLS
710 720 730 740 750
VTRGDLIKLF CIVTVDGAVL DPDDMAFDVS WFAVHSFGLD KAPILLSSLD
760 770 780 790 800
RKGVVTTGQR DWKSTVSLER VSVLEFLLQV HSSEDQDFGN YYCSVTPWVR
810 820 830 840 850
SPTGSWQREA EIHSRPIFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI
860 870
GYCSSHWCCK KEVRETRRER RRLMSMEMD
Length:879
Mass (Da):98,731
Last modified:November 1, 1996 - v1
Checksum:iDE7012D3B346C0F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471D → G.
Natural varianti136 – 1361M → V.
Natural varianti782 – 7821S → G.
Natural varianti844 – 8441G → R.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26595 mRNA. Translation: AAC18426.1.
RefSeqiNP_062116.1. NM_019243.1.
UniGeneiRn.6332.

Genome annotation databases

GeneIDi29602.
KEGGirno:29602.
UCSCiRGD:3437. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26595 mRNA. Translation: AAC18426.1.
RefSeqiNP_062116.1. NM_019243.1.
UniGeneiRn.6332.

3D structure databases

ProteinModelPortaliQ62786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62786. 1 interaction.
STRINGi10116.ENSRNOP00000021162.

PTM databases

iPTMnetiQ62786.
PhosphoSiteiQ62786.
SwissPalmiQ62786.

Proteomic databases

PaxDbiQ62786.
PRIDEiQ62786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29602.
KEGGirno:29602.
UCSCiRGD:3437. rat.

Organism-specific databases

CTDi5738.
RGDi3437. Ptgfrn.

Phylogenomic databases

eggNOGiENOG410IHZG. Eukaryota.
ENOG4111FCJ. LUCA.
HOGENOMiHOG000112641.
HOVERGENiHBG031554.
InParanoidiQ62786.
KOiK06729.
PhylomeDBiQ62786.

Miscellaneous databases

NextBioi609768.
PROiQ62786.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and proposed structure for a prostaglandin F2 alpha receptor regulatory protein."
    Orlicky D.J., Nordeen S.K.
    Prostaglandins Leukot. Essent. Fatty Acids 55:261-268(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  2. "Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)."
    Orlicky D.J.
    Prostaglandins Leukot. Essent. Fatty Acids 54:247-259(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  3. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-271, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFPRP_RAT
AccessioniPrimary (citable) accession number: Q62786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.