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Protein

28 kDa heat- and acid-stable phosphoprotein

Gene

Pdap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
28 kDa heat- and acid-stable phosphoprotein
Alternative name(s):
PDGF-associated protein
Short name:
PAP
PDGFA-associated protein 1
Short name:
PAP1
Gene namesi
Name:Pdap1
Synonyms:Haspp28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620442. Pdap1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838991 – 18128 kDa heat- and acid-stable phosphoproteinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei19PhosphoserineBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei57PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei70PhosphotyrosineBy similarity1
Modified residuei126N6-methyllysineBy similarity1
Modified residuei132N6-acetyllysineBy similarity1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei178PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by several kinases in vitro. In vivo, can be phosphorylated by CK2.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62785.
PRIDEiQ62785.

PTM databases

iPTMnetiQ62785.
PhosphoSitePlusiQ62785.

Expressioni

Tissue specificityi

Present in all tissues tested, including brain, lung, spleen, kidney, liver, heart, and muscle, in decreasing order of abundance.

Gene expression databases

BgeeiENSRNOG00000000990.
GenevisibleiQ62785. RN.

Interactioni

Protein-protein interaction databases

BioGridi249111. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ62785.
SMRiQ62785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3375. Eukaryota.
ENOG4111T3A. LUCA.
GeneTreeiENSGT00390000018509.
HOGENOMiHOG000241539.
HOVERGENiHBG000319.
InParanoidiQ62785.
OMAiKHFSRDL.
OrthoDBiEOG091G16GX.
PhylomeDBiQ62785.
TreeFamiTF324338.

Family and domain databases

InterProiView protein in InterPro
IPR019380. Casein_kinase_sb_PP28.
PfamiView protein in Pfam
PF10252. PP28. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGGRKGGH KGRVRQYTSP EEIDAQLQAE KQKANEEDEQ EEGGDGASGD
60 70 80 90 100
PKKEKKSLDS DESEDEDDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD
110 120 130 140 150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR
160 170 180
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K
Length:181
Mass (Da):20,605
Last modified:November 1, 1996 - v1
Checksum:iC9A74B7C41174F87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13R → S in AAC52531 (PubMed:8780057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26541 mRNA. Translation: AAC52455.1.
U41744 mRNA. Translation: AAC52531.1.
BC088140 mRNA. Translation: AAH88140.1.
PIRiS62782.
RefSeqiNP_072117.1. NM_022595.1.
UniGeneiRn.6158.

Genome annotation databases

EnsembliENSRNOT00000001310; ENSRNOP00000001310; ENSRNOG00000000990.
GeneIDi64527.
KEGGirno:64527.

Similar proteinsi

Entry informationi

Entry nameiHAP28_RAT
AccessioniPrimary (citable) accession number: Q62785
Secondary accession number(s): Q62890
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families