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Protein

Type I inositol 3,4-bisphosphate 4-phosphatase

Gene

Inpp4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.66. 5301.
UniPathwayiUPA00944.

Chemistry

SwissLipidsiSLP:000000897.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type I
Gene namesi
Name:Inpp4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68386. Inpp4a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 939939Type I inositol 3,4-bisphosphate 4-phosphatasePRO_0000190234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei355 – 3551PhosphotyrosineBy similarity
Modified residuei488 – 4881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62784.
PRIDEiQ62784.

PTM databases

iPTMnetiQ62784.
PhosphoSiteiQ62784.

Expressioni

Tissue specificityi

Widely expressed. Expressed at highest levels in the brain, heart and skeletal muscle.1 Publication

Interactioni

Subunit structurei

Interacts with INPP5F.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024330.

Structurei

3D structure databases

ProteinModelPortaliQ62784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 137107C2Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiQ62784.
KOiK01109.
PhylomeDBiQ62784.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62784-1) [UniParc]FASTAAdd to basket

Also known as: Alpha1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAREHSPRH GARARAMQRA STIDVTADMV GLSLAGNIQD PDEPILEFSL
60 70 80 90 100
ACSELHTPSL DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS
110 120 130 140 150
IAFFQDSLIN QMTQIKLSVY DVKDRSQGTM YLLGSGTFVV KDLLQDRHHR
160 170 180 190 200
LHLTLRSAES DRVGNITVIG WQMEEKSDQQ PPVTRSLDTV NGRMVLPVDE
210 220 230 240 250
SLTEALGIRS KYASLRKDSL LKAVFGGAIC RMYRFPTTDG NHLRILEQMA
260 270 280 290 300
ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT
310 320 330 340 350
IILTYQENLT DLHQYKGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG
360 370 380 390 400
SDQNYDVVTI GAPAAHCQGF KSGGLRKKLH KFEEAKKHSF EECCTSSTCQ
410 420 430 440 450
SIIYIPQDVV RAKEIIAQIN TLKTQVSYYA ERLSRAAKDR SATGLERTLA
460 470 480 490 500
ILADKTRQLV TVCDCKLLAN SIHGLNAARP DYIASKASPT STEEEQVMLR
510 520 530 540 550
NDQDTLMARW AGRSSRSSLQ VDWHEEEWEK VWLNVDKSLE CIIQRVDKLL
560 570 580 590 600
QKERLHGEGG EDVFPCSSTC SSKKDCSPPP EESCPGEWSE ALYPLLTTLT
610 620 630 640 650
DCVAMMSDKA KAAMVFLLMQ TAAPTIASYL SLQYRRDVVF CQTLTALICG
660 670 680 690 700
FIIKLRNCLH DGGFLRQLYT IGLLAQFESL LSTYGEELAM LEDMSLGIMD
710 720 730 740 750
LRNVTFKVTQ ATSNASSDML PVITGNRDGF NVRIPLPGPL FDSLPREIQS
760 770 780 790 800
GMLLRVQPVL FNVGINEQQT LAERFGDTSL QEVINVESLV RLNSYFEQFK
810 820 830 840 850
EVLPEDCLPR SRSQTCLPEL LRFLGQNVHA RKNKNVDILW QAAEVCRRLN
860 870 880 890 900
GVRFTSCKSA KDRTAMSVTL EQCLILQHEH GMAPQVFTQA LECMRSEGCR
910 920 930
RENTMKNVGS RKYAFNSLQL KAFPKHYRPP EGTYGKVET
Length:939
Mass (Da):105,589
Last modified:November 1, 1996 - v1
Checksum:i1DC4B3F0A8F47D0D
GO
Isoform 2 (identifier: Q62784-2) [UniParc]FASTAAdd to basket

Also known as: Alpha2

The sequence of this isoform differs from the canonical sequence as follows:
     575-585: Missing.

Show »
Length:928
Mass (Da):104,447
Checksum:i1E3E2D631437E265
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei575 – 58511Missing in isoform 2. 1 PublicationVSP_015247Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26397 mRNA. Translation: AAB01069.1.
PIRiA57487.
RefSeqiNP_112264.3. NM_031002.3. [Q62784-1]
UniGeneiRn.11215.

Genome annotation databases

GeneIDi80849.
KEGGirno:80849.
UCSCiRGD:68386. rat. [Q62784-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26397 mRNA. Translation: AAB01069.1.
PIRiA57487.
RefSeqiNP_112264.3. NM_031002.3. [Q62784-1]
UniGeneiRn.11215.

3D structure databases

ProteinModelPortaliQ62784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024330.

Chemistry

SwissLipidsiSLP:000000897.

PTM databases

iPTMnetiQ62784.
PhosphoSiteiQ62784.

Proteomic databases

PaxDbiQ62784.
PRIDEiQ62784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80849.
KEGGirno:80849.
UCSCiRGD:68386. rat. [Q62784-1]

Organism-specific databases

CTDi3631.
RGDi68386. Inpp4a.

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiQ62784.
KOiK01109.
PhylomeDBiQ62784.

Enzyme and pathway databases

UniPathwayiUPA00944.
BRENDAi3.1.3.66. 5301.

Miscellaneous databases

NextBioi614898.
PROiQ62784.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase."
    Norris F.A., Auethavekiat V., Majerus P.W.
    J. Biol. Chem. 270:16128-16133(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 22-48; 245-248; 330-342; 494-504; 747-752; 755-781; 795-804 AND 927-939, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiINP4A_RAT
AccessioniPrimary (citable) accession number: Q62784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.