Q62784 (INP4A_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 67.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Type I inositol-3,4-bisphosphate 4-phosphatase EC=3.1.3.66 Alternative name(s): Inositol polyphosphate 4-phosphatase type I | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 939 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. |
| Catalytic activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Tissue specificity | Widely expressed. Expressed at highest levels in the brain, heart and skeletal muscle. Ref.1 |
| Sequence similarities | Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Traceable author statement Ref.1. Source: RGD phosphatidylinositol-4,5-bisphosphate 4-phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q62784-1) Also known as: Alpha1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q62784-2) Also known as: Alpha2; The sequence of this isoform differs from the canonical sequence as follows: 575-585: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 939 | 939 | Type I inositol-3,4-bisphosphate 4-phosphatase | PRO_0000190234 | |||||
Regions | |||||||||
| Domain | 31 – 137 | 107 | C2 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 355 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 488 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 575 – 585 | 11 | Missing in isoform 2. | VSP_015247 | |||||
Sequences
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References
| [1] | "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase." Norris F.A., Auethavekiat V., Majerus P.W. J. Biol. Chem. 270:16128-16133(1995) [PubMed: 7608176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 22-48; 245-248; 330-342; 494-504; 747-752; 755-781; 795-804 AND 927-939, TISSUE SPECIFICITY. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U26397 mRNA. Translation: AAB01069.1. |
| IPI | IPI00208276. IPI00650127. |
| PIR | A57487. |
| RefSeq | NP_112264.3. NM_031002.3. |
| UniGene | Rn.11215. |
3D structure databases | |
| ProteinModelPortal | Q62784. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q62784. |
PTM databases | |
| PhosphoSite | Q62784. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 80849. |
| KEGG | rno:80849. |
| UCSC | NM_031002. rat. |
Organism-specific databases | |
| CTD | 3631. |
| RGD | 68386. Inpp4a. |
Phylogenomic databases | |
| eggNOG | roNOG12714. |
| GeneTree | ENSGT00390000002033. |
| HOVERGEN | HBG081796. |
| InParanoid | Q62784. |
| OrthoDB | EOG4G7BXN. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.66. 5301. |
Gene expression databases | |
| ArrayExpress | Q62784. |
| Genevestigator | Q62784. |
| GermOnline | ENSRNOG00000017660. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view] |
| KO | K01109. |
| SUPFAM | SSF49562. C2_CaLB. 1 hit. |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 614898. |
Entry information
| Entry name | INP4A_RAT | ||||||||
| Accession | Primary (citable) accession number: Q62784 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |