Reviewed, UniProtKB/Swiss-Prot Q62784 (INP4A_RAT)

Names and origin

Protein names

Recommended name:
    Type I inositol-3,4-bisphosphate 4-phosphatase
    EC=3.1.3.66
Alternative name(s):
    Inositol polyphosphate 4-phosphatase type I

Gene names

Name:

Inpp4a

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	939 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.
Catalytic activity	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Tissue specificity	Widely expressed. Expressed at highest levels in the brain, heart and skeletal muscle. Ref.1
Sequence similarities	Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Ref.1 Traceable author statement. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q62784-1)

Also known as: Alpha1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q62784-2)

Also known as: Alpha2;

The sequence of this isoform differs from the canonical sequence as follows:
     575-585: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 939	939	Type I inositol-3,4-bisphosphate 4-phosphatase		PRO_0000190234
Regions
	Domain	31 – 137	107	C2
Amino acid modifications
	Modified residue	355	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	575 – 585	11	Missing in isoform 2.		VSP_015247

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha1) [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1DC4B3F0A8F47D0D	FASTA	939	105,589
	10 20 30 40 50 60 MTAREHSPRH GARARAMQRA STIDVTADMV GLSLAGNIQD PDEPILEFSL ACSELHTPSL 70 80 90 100 110 120 DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQIKLSVY 130 140 150 160 170 180 DVKDRSQGTM YLLGSGTFVV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQQ 190 200 210 220 230 240 PPVTRSLDTV NGRMVLPVDE SLTEALGIRS KYASLRKDSL LKAVFGGAIC RMYRFPTTDG 250 260 270 280 290 300 NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 310 320 330 340 350 360 IILTYQENLT DLHQYKGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDVVTI 370 380 390 400 410 420 GAPAAHCQGF KSGGLRKKLH KFEEAKKHSF EECCTSSTCQ SIIYIPQDVV RAKEIIAQIN 430 440 450 460 470 480 TLKTQVSYYA ERLSRAAKDR SATGLERTLA ILADKTRQLV TVCDCKLLAN SIHGLNAARP 490 500 510 520 530 540 DYIASKASPT STEEEQVMLR NDQDTLMARW AGRSSRSSLQ VDWHEEEWEK VWLNVDKSLE 550 560 570 580 590 600 CIIQRVDKLL QKERLHGEGG EDVFPCSSTC SSKKDCSPPP EESCPGEWSE ALYPLLTTLT 610 620 630 640 650 660 DCVAMMSDKA KAAMVFLLMQ TAAPTIASYL SLQYRRDVVF CQTLTALICG FIIKLRNCLH 670 680 690 700 710 720 DGGFLRQLYT IGLLAQFESL LSTYGEELAM LEDMSLGIMD LRNVTFKVTQ ATSNASSDML 730 740 750 760 770 780 PVITGNRDGF NVRIPLPGPL FDSLPREIQS GMLLRVQPVL FNVGINEQQT LAERFGDTSL 790 800 810 820 830 840 QEVINVESLV RLNSYFEQFK EVLPEDCLPR SRSQTCLPEL LRFLGQNVHA RKNKNVDILW 850 860 870 880 890 900 QAAEVCRRLN GVRFTSCKSA KDRTAMSVTL EQCLILQHEH GMAPQVFTQA LECMRSEGCR 910 920 930 RENTMKNVGS RKYAFNSLQL KAFPKHYRPP EGTYGKVET
	Isoform 2 (Alpha2). Checksum: 1E3E2D631437E265	FASTA	928	104,447
	10 20 30 40 50 60 MTAREHSPRH GARARAMQRA STIDVTADMV GLSLAGNIQD PDEPILEFSL ACSELHTPSL 70 80 90 100 110 120 DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQIKLSVY 130 140 150 160 170 180 DVKDRSQGTM YLLGSGTFVV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQQ 190 200 210 220 230 240 PPVTRSLDTV NGRMVLPVDE SLTEALGIRS KYASLRKDSL LKAVFGGAIC RMYRFPTTDG 250 260 270 280 290 300 NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 310 320 330 340 350 360 IILTYQENLT DLHQYKGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDVVTI 370 380 390 400 410 420 GAPAAHCQGF KSGGLRKKLH KFEEAKKHSF EECCTSSTCQ SIIYIPQDVV RAKEIIAQIN 430 440 450 460 470 480 TLKTQVSYYA ERLSRAAKDR SATGLERTLA ILADKTRQLV TVCDCKLLAN SIHGLNAARP 490 500 510 520 530 540 DYIASKASPT STEEEQVMLR NDQDTLMARW AGRSSRSSLQ VDWHEEEWEK VWLNVDKSLE 550 560 570 580 590 600 CIIQRVDKLL QKERLHGEGG EDVFPCSSTC SSKKGEWSEA LYPLLTTLTD CVAMMSDKAK 610 620 630 640 650 660 AAMVFLLMQT AAPTIASYLS LQYRRDVVFC QTLTALICGF IIKLRNCLHD GGFLRQLYTI 670 680 690 700 710 720 GLLAQFESLL STYGEELAML EDMSLGIMDL RNVTFKVTQA TSNASSDMLP VITGNRDGFN 730 740 750 760 770 780 VRIPLPGPLF DSLPREIQSG MLLRVQPVLF NVGINEQQTL AERFGDTSLQ EVINVESLVR 790 800 810 820 830 840 LNSYFEQFKE VLPEDCLPRS RSQTCLPELL RFLGQNVHAR KNKNVDILWQ AAEVCRRLNG 850 860 870 880 890 900 VRFTSCKSAK DRTAMSVTLE QCLILQHEHG MAPQVFTQAL ECMRSEGCRR ENTMKNVGSR 910 920 KYAFNSLQLK AFPKHYRPPE GTYGKVET

References

[1]

"The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase." Norris F.A., Auethavekiat V., Majerus P.W. J. Biol. Chem. 270:16128-16133(1995) [PubMed: 7608176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 22-48; 245-248; 330-342; 494-504; 747-752; 755-781; 795-804 AND 927-939, TISSUE SPECIFICITY. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U26397 mRNA. Translation: AAB01069.1.
IPI	IPI00208276. IPI00650127.
PIR	A57487.
RefSeq	NP_112264.3.
UniGene	Rn.11215
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000017660. Rattus norvegicus. [Contig view]
GeneID	80849.
KEGG	rno:80849.
Organism-specific databases
RGD	68386. Inpp4a.
Phylogenomic databases
HOVERGEN	Q62784.
Enzyme and pathway databases
BRENDA	3.1.3.66. 248.
Gene expression databases
ArrayExpress	Q62784.
GermOnline	ENSRNOG00000017660. Rattus norvegicus.
Family and domain databases
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	614898.

Entry information

Entry name

INP4A_RAT

Accession

Primary (citable) accession number: Q62784

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)