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Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi90 – 149HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
ARIX1 homeodomain protein
Aristaless homeobox protein homolog
Paired-like homeobox 2A
Gene namesi
Name:Phox2a
Synonyms:Arix, Pmx2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621323 Phox2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492611 – 281Paired mesoderm homeobox protein 2AAdd BLAST281

Proteomic databases

PaxDbiQ62782

Expressioni

Tissue specificityi

Expressed in sympathetic superior cervical ganglia and in noradrenergic, dopamine beta-hydroxylase (DBH)-positive tissues. Not expressed in brain.

Developmental stagei

Expressed at E18 day in sympathetic ganglia.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026702

Structurei

3D structure databases

ProteinModelPortaliQ62782
SMRiQ62782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 199Poly-Pro7
Compositional biasi234 – 243Poly-Gly10

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0484 Eukaryota
ENOG4111QRU LUCA
HOGENOMiHOG000013060
HOVERGENiHBG053590
InParanoidiQ62782
KOiK09330
PhylomeDBiQ62782

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q62782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP
60 70 80 90 100
ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA
110 120 130 140 150
QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER
160 170 180 190 200
AATAKGAAGA TGAKKGEARC SSEDDDSKES TCSHTPDSTA SLPPPPPAPS
210 220 230 240 250
LASPLLSPSP LPAALGSGPG PQPLKGALWA GVAGGGGGGP GTGAAELLKA
260 270 280
WQPAEPGPGP FSGVLSSFHR KPGPALKTNL F
Length:281
Mass (Da):29,525
Last modified:November 1, 1996 - v1
Checksum:iE6F4626DE0014B9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25967 mRNA Translation: AAB04168.1
RefSeqiNP_446321.1, NM_053869.1
UniGeneiRn.2858

Genome annotation databases

GeneIDi116648
KEGGirno:116648
UCSCiRGD:621323 rat

Similar proteinsi

Entry informationi

Entry nameiPHX2A_RAT
AccessioniPrimary (citable) accession number: Q62782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health