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Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 14960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
ARIX1 homeodomain protein
Aristaless homeobox protein homolog
Paired-like homeobox 2A
Gene namesi
Name:Phox2a
Synonyms:Arix, Pmx2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621323. Phox2a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Paired mesoderm homeobox protein 2APRO_0000049261Add
BLAST

Proteomic databases

PaxDbiQ62782.

Expressioni

Tissue specificityi

Expressed in sympathetic superior cervical ganglia and in noradrenergic, dopamine beta-hydroxylase (DBH)-positive tissues. Not expressed in brain.

Developmental stagei

Expressed at E18 day in sympathetic ganglia.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026702.

Structurei

3D structure databases

ProteinModelPortaliQ62782.
SMRiQ62782. Positions 89-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 1997Poly-Pro
Compositional biasi234 – 24310Poly-Gly

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0484. Eukaryota.
ENOG4111QRU. LUCA.
HOGENOMiHOG000013060.
HOVERGENiHBG053590.
InParanoidiQ62782.
KOiK09330.
PhylomeDBiQ62782.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP
60 70 80 90 100
ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA
110 120 130 140 150
QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER
160 170 180 190 200
AATAKGAAGA TGAKKGEARC SSEDDDSKES TCSHTPDSTA SLPPPPPAPS
210 220 230 240 250
LASPLLSPSP LPAALGSGPG PQPLKGALWA GVAGGGGGGP GTGAAELLKA
260 270 280
WQPAEPGPGP FSGVLSSFHR KPGPALKTNL F
Length:281
Mass (Da):29,525
Last modified:November 1, 1996 - v1
Checksum:iE6F4626DE0014B9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25967 mRNA. Translation: AAB04168.1.
RefSeqiNP_446321.1. NM_053869.1.
UniGeneiRn.2858.

Genome annotation databases

GeneIDi116648.
KEGGirno:116648.
UCSCiRGD:621323. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25967 mRNA. Translation: AAB04168.1.
RefSeqiNP_446321.1. NM_053869.1.
UniGeneiRn.2858.

3D structure databases

ProteinModelPortaliQ62782.
SMRiQ62782. Positions 89-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026702.

Proteomic databases

PaxDbiQ62782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116648.
KEGGirno:116648.
UCSCiRGD:621323. rat.

Organism-specific databases

CTDi401.
RGDi621323. Phox2a.

Phylogenomic databases

eggNOGiKOG0484. Eukaryota.
ENOG4111QRU. LUCA.
HOGENOMiHOG000013060.
HOVERGENiHBG053590.
InParanoidiQ62782.
KOiK09330.
PhylomeDBiQ62782.

Miscellaneous databases

NextBioi619395.
PROiQ62782.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes."
    Zellmer E., Zhang Z., Greco D., Rhodes J., Cassel S., Lewis E.J.
    J. Neurosci. 15:8109-8120(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPHX2A_RAT
AccessioniPrimary (citable) accession number: Q62782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.