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Protein

Probable ATP-dependent RNA helicase DDX46

Gene

Ddx46

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in splicing, either prior to, or during A complex formation.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX46 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 46
Helicase of 117.4 kDa
Gene namesi
Name:Ddx46
Synonyms:Hel117
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi708480 Ddx46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000551242 – 1032Probable ATP-dependent RNA helicase DDX46Add BLAST1031

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei199PhosphoserineCombined sources1
Modified residuei263N6-acetyllysineBy similarity1
Modified residuei294PhosphotyrosineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei346PhosphoserineBy similarity1
Modified residuei776N6-acetyllysineBy similarity1
Cross-linki779Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei804PhosphoserineCombined sources1
Modified residuei904N6-acetyllysineBy similarity1
Cross-linki908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki916Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei929PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62780
PRIDEiQ62780

PTM databases

iPTMnetiQ62780
PhosphoSitePlusiQ62780

Expressioni

Gene expression databases

BgeeiENSRNOG00000021637
GenevisibleiQ62780 RN

Interactioni

Subunit structurei

Integral component of the 17S U2 snRNP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030772

Structurei

3D structure databases

ProteinModelPortaliQ62780
SMRiQ62780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini403 – 581Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST179
Domaini592 – 753Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 197Sequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 400Q motifAdd BLAST29
Motifi529 – 532DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 103Arg-richAdd BLAST101
Compositional biasi202 – 209Poly-Asp8
Compositional biasi297 – 300Poly-Glu4

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0334 Eukaryota
ENOG410XSQV LUCA
GeneTreeiENSGT00900000140983
HOGENOMiHOG000007229
HOVERGENiHBG081426
InParanoidiQ62780
KOiK12811
OMAiSKFHSIR
OrthoDBiEOG091G02BY
PhylomeDBiQ62780
TreeFamiTF354236

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE
60 70 80 90 100
RSRSRDKRRS RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR
110 120 130 140 150
RSRSSSPGSK SKKAENRSRS KEKAEGGDSS KEKKKDKDDK EDEKEKDAGN
160 170 180 190 200
FDQNKLEEEM RKRKERVEKW REEQRKKAME NIGELKKEIE EMKQGKKWSL
210 220 230 240 250
EDDDDDEDDP AEAEKEGNEM EDEELDPLDA YMEEVKEEVK KFNMRSVKGG
260 270 280 290 300
AGNEKKSGPT VTKVVTVVTT KKAVVDADKK KGELMENDQD AMEYSSEEEE
310 320 330 340 350
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV
360 370 380 390 400
NVFRLEMEGI TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT
410 420 430 440 450
QAIPAIMSGR DLIGIAKTGS GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI
460 470 480 490 500
MTPTRELALQ ITKECKKFSK TLGLRVVCVY GGTGISEQIA ELKRGAEIIV
510 520 530 540 550
CTPGRMIDML AANSGRVTNL RRVTYVVLDE ADRMFDMGFE PQVMRIVDNV
560 570 580 590 600
RPDRQTVMFS ATFPRAMEAL ARRILSKPIE VQVGGRSVVC SDVEQQVIVI
610 620 630 640 650
EEEKKFLKLL ELLGHYQESG SVIIFVDKQE HADGLLKDLM RASYPCMSLH
660 670 680 690 700
GGIDQYDRDS IINDFKNGTC KLLVATSVAA RGLDVKHLIL VVNYSCPNHY
710 720 730 740 750
EDYVHRAGRT GRAGNKGYAY TFITEDQARY AGDIIKALEL SGTAVPPDLE
760 770 780 790 800
KLWSDFKDQQ KAEGKIIKKS SGFSGKGFKF DETEQALANE RKKLQKAALG
810 820 830 840 850
LQDSDDEDAA VDIDEQIESM FNSKKRVKDM AAPGTSSAPA PTAGNAEKLE
860 870 880 890 900
IAKRLALRIN AQKNLGIESQ VDVMQQATNA ILRGGPLLAP TVSAKTIAEQ
910 920 930 940 950
LAEKINAKLN YVPLEKQEEE RQEGGQSESF KRYEEELEIN DFPQTARWKV
960 970 980 990 1000
TSKEALQRIS EYSEAAITIR GTYFPPGKEP KEGERKIYLA IESANELAVQ
1010 1020 1030
KAKAEITRLI KEELIRLQNS YQPTNKGRYK VL
Length:1,032
Mass (Da):117,385
Last modified:November 1, 1996 - v1
Checksum:i5A86E159EC742EC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25746 mRNA Translation: AAC52210.1
BC107590 mRNA Translation: AAI07591.1
PIRiA57514
RefSeqiNP_620798.1, NM_139098.1
UniGeneiRn.3436

Genome annotation databases

EnsembliENSRNOT00000029885; ENSRNOP00000030772; ENSRNOG00000021637
GeneIDi245957
KEGGirno:245957
UCSCiRGD:708480 rat

Similar proteinsi

Entry informationi

Entry nameiDDX46_RAT
AccessioniPrimary (citable) accession number: Q62780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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