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Protein

Protein unc-13 homolog C

Gene

Unc13c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1087 – 113751Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-13 homolog C
Alternative name(s):
Munc13-3
Gene namesi
Name:Unc13c
Synonyms:Unc13h3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628592. Unc13c.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Cell junctionsynapsepresynaptic cell membrane 1 Publication; Peripheral membrane protein 1 Publication

  • Note: Localized to presynaptic structures.Curated

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: RGD
  • presynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22042204Protein unc-13 homolog CPRO_0000188580Add
BLAST

Proteomic databases

PaxDbiQ62770.
PRIDEiQ62770.

PTM databases

iPTMnetiQ62770.
PhosphoSiteiQ62770.

Expressioni

Tissue specificityi

Exclusively expressed in brain, predominantly in the cerebellum.2 Publications

Developmental stagei

First detected at birth, after which expression level is steadily increasing until it reaches a plateau at P15.1 Publication

Interactioni

Subunit structurei

Interacts with STX1A and/or STX1B1, VAMP2 and SNAP25.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010330.

Structurei

3D structure databases

ProteinModelPortaliQ62770.
SMRiQ62770. Positions 1088-1137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1197 – 1303107C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini1627 – 1770144MHD1PROSITE-ProRule annotationAdd
BLAST
Domaini1876 – 2018143MHD2PROSITE-ProRule annotationAdd
BLAST
Domaini2038 – 2143106C2 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili961 – 98424Sequence analysisAdd
BLAST

Domaini

The C2 domains are not involved in calcium-dependent phospholipid binding.

Sequence similaritiesi

Belongs to the unc-13 family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 MHD1 (MUNC13 homology domain 1) domain.PROSITE-ProRule annotation
Contains 1 MHD2 (MUNC13 homology domain 2) domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1087 – 113751Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
HOGENOMiHOG000154775.
HOVERGENiHBG108648.
InParanoidiQ62770.
KOiK15293.
PhylomeDBiQ62770.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
IPR027087. Unc13C.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PTHR10480:SF2. PTHR10480:SF2. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 2 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 2 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASLFKSLI LAYIHKLCKG MFTKKLGNTT KKKENRQQNK DQDFPTAGHT
60 70 80 90 100
KPPKLSNALK STVKKIAKCS STRNFSVEDE EGHKDFSLSP TFSYRVAIAN
110 120 130 140 150
GLQTAVTNSD EDLLQELSSI ESSYSESFNE LRSSTENQVQ STHTMPVRRN
160 170 180 190 200
RKSSSSLAPS EGSSDGERTL HTLKLGALRK LRKWKKSQEC VSSDSELSTV
210 220 230 240 250
KKTWGIRSKS LDRTARNPKT NVLEPGFSSS GCISQTHDVM EMIFKELQGI
260 270 280 290 300
SQIETELSEL RGHVNALKYS IDEISSSVEV VQSEIEQLRT GFVQARRETR
310 320 330 340 350
DIHDYIKHLG HMGSKVSLRF LNVPEERHEY VESVVYQILV DKMGFSDVPN
360 370 380 390 400
AIKIEFAQRI GQQRDCPNAK PRPILVYFET PQQRDSVLKK SYKLKGTGIA
410 420 430 440 450
ISTDILTYDI RERKEKGVLP SSQTYESMDM KLSTPEPKAK KNAWLSPNDS
460 470 480 490 500
DRELESDLSR SSYADSPAKG SSSKSSSKSH SARSKNKAAN SRTSQKSDYN
510 520 530 540 550
KRPSKPPASE KPTPHYVEAT PLWHSQSDFF TPKLSRSESD FSKLCQSYSE
560 570 580 590 600
DFSESQFFCR TNGSSLLSSS DRELWQRKQE GMTALYHSPQ DQGLDGNIPT
610 620 630 640 650
VPGQGEIENT ETVDSGMSNS VVCASGDRSN YSGSQLSLHE DLSPWKEWNQ
660 670 680 690 700
AGHGTDGLDS STQEPFDYDT NSLSDQQLDM SSKDLDDLGK CHSDLQDDSE
710 720 730 740 750
SYDLTQDDNS SPCPGLDNEP QGQWVGQYDS YQKTNSNDLY PNQSHPSMMY
760 770 780 790 800
RSQSELQSDD SEAAQPKSWH SRLSIDLSDK TFKFPKFGST LQRAKSALEV
810 820 830 840 850
VWNKSTQSLS GCEDSGSSLM GRFRTLSQST ANESSTTLDS DIYTEPYYYK
860 870 880 890 900
AEEEEDYCEP VADSETDYVE VMEQVLAKLE NRTSVTEVDE HIKEYDHPSY
910 920 930 940 950
ETPYETPQDE GYDGQADDII SEGELETLNE PAVEMELVED ESQNLPVEPP
960 970 980 990 1000
EVMKPKRIRP SFKEAALRAY KKQMAELEEK ILAGDSSSVD EKARIVSGND
1010 1020 1030 1040 1050
LDASKFSALQ VFGGAGRGLY GIDSMPDLRR KKTLPIVRDV AMTLAARKSG
1060 1070 1080 1090 1100
LSLAMVIRTS LNNEELKMHV FRKTLQALIY PISSTTPHNF EVWTATTPTY
1110 1120 1130 1140 1150
CYECEGLLWG IARQGMKCLE CGVKCHEKCQ DLLNADCLQR AAEKSSKHGA
1160 1170 1180 1190 1200
EDKTQTIITA MKERMKIRER NRPEVFEVIQ EMFQISKEDF VQYTKAAKQS
1210 1220 1230 1240 1250
VLDGTSKWSA KITITVVSAQ GLQAKDKTGS SDPYVTVQVG KNKRRTKTIF
1260 1270 1280 1290 1300
GNLNPVWDEK FYFECHNSTD RIKVRVWDED DDIKSRVKQH FKKESDDFLG
1310 1320 1330 1340 1350
QTIVEVRTLS GEMDVWYNLE KRTDKSAVSG AIRLKINVEI KGEEKVAPYH
1360 1370 1380 1390 1400
IQYTCLHENL FHYLTEVKSN GSVKIPEVKG DEAWKVFFDD ASQEIVDEFA
1410 1420 1430 1440 1450
MRYGVESIYQ AMTHFSCLSS KYMCPGVPAV MSALLANINA FYAHTTVSTN
1460 1470 1480 1490 1500
VQVSASDRFA ATNFGREKFI KLLDQLHNSL RIDLSKYREN FPASNSERLQ
1510 1520 1530 1540 1550
DLKSTVDLLT SITFFRMKVL ELQSPPKASA VVKDCVRACL DSTYKYIFDN
1560 1570 1580 1590 1600
CHELYSQLID PSKKQDVPRE EQGPTTKNLD FWPQLITLMV TIIDEDKTAY
1610 1620 1630 1640 1650
TPVLNQFPQE LNMGKISAEI MWSLFALDMK YALEEHEKQR LCKSTDYMNL
1660 1670 1680 1690 1700
HFKVKWFYNE YVRELPAFKD AVPEYSLWFE PFVMQWLDEN EDVSMEFLHG
1710 1720 1730 1740 1750
ALGRDKKDGF QQTSDHALFS CSVVDVFAQL NQSFEIIKKL ECPNPEALSH
1760 1770 1780 1790 1800
LMRRFAKTIN KVLVQYAAIV SSDFSSYCDK ETVPCILMNN IQQLRVQLEK
1810 1820 1830 1840 1850
MFESMGGKEL DPEASTILKE LQIKLNGVLD ALSVTYGESF QLVIEECIKQ
1860 1870 1880 1890 1900
MGAELNQMRA NGNSAANKNN AAMDAEIVLR PLMDFLDKIL SLSAKICEKT
1910 1920 1930 1940 1950
VLKRVLKELW KLVLNKIEKQ IVLPPLTDQT GPQMIFIAAK ELGQLSKLKE
1960 1970 1980 1990 2000
HMIRDDAKGL TPRQCAIMEV VLATIKQYFH AGGNGLKKNF LEKSPDLHSL
2010 2020 2030 2040 2050
RYALSLYTQT TDALIKKFIE TQGSQSRSSK DAVGQISVHV DVTTTPGTGE
2060 2070 2080 2090 2100
HKVTVKVIAI NDLNWQTTTM FRPFVEVCML GPSLGDKKRK QGTKTKSNTW
2110 2120 2130 2140 2150
SPKYNETFQF ILGNENRPGA YELHLSVKDY CFAREDRIIG MTVIQLQNIA
2160 2170 2180 2190 2200
EKGSYGAWYP LLKNLSMDET GLTILRILSQ RTSDDVAKEF VRLKSETRSI

DESA
Length:2,204
Mass (Da):249,136
Last modified:August 16, 2004 - v3
Checksum:i13F1C251FA28E00E
GO

Sequence cautioni

The sequence AAB39720.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75361 mRNA. Translation: AAB39720.1. Different initiation.
PIRiT42759.
RefSeqiNP_775169.4. NM_173146.2.
UniGeneiRn.11278.

Genome annotation databases

GeneIDi286931.
KEGGirno:286931.
UCSCiRGD:628592. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75361 mRNA. Translation: AAB39720.1. Different initiation.
PIRiT42759.
RefSeqiNP_775169.4. NM_173146.2.
UniGeneiRn.11278.

3D structure databases

ProteinModelPortaliQ62770.
SMRiQ62770. Positions 1088-1137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010330.

PTM databases

iPTMnetiQ62770.
PhosphoSiteiQ62770.

Proteomic databases

PaxDbiQ62770.
PRIDEiQ62770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286931.
KEGGirno:286931.
UCSCiRGD:628592. rat.

Organism-specific databases

CTDi440279.
RGDi628592. Unc13c.

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
HOGENOMiHOG000154775.
HOVERGENiHBG108648.
InParanoidiQ62770.
KOiK15293.
PhylomeDBiQ62770.

Miscellaneous databases

NextBioi625104.
PROiQ62770.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
IPR027087. Unc13C.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PTHR10480:SF2. PTHR10480:SF2. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 2 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 2 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Telemenakis I., Brose N., Suedhof T.C.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins."
    Brose N., Hofmann K., Hata Y., Suedhof T.C.
    J. Biol. Chem. 270:25273-25280(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 942-1634, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Differential expression of two novel Munc13 proteins in rat brain."
    Augustin I., Betz A., Herrmann C., Jo T., Brose N.
    Biochem. J. 337:363-371(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH SYNTAXIN 1; VAMP2 AND SNAP25.

Entry informationi

Entry nameiUN13C_RAT
AccessioniPrimary (citable) accession number: Q62770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.