Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62767

- DUS4_RAT

UniProt

Q62767 - DUS4_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dual specificity protein phosphatase 4

Gene

Dusp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: RGD
  2. protein tyrosine/threonine phosphatase activity Source: RGD
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. endoderm formation Source: RefGenome
  2. inactivation of MAPK activity Source: GOC
  3. protein dephosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 4 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 2
Short name:
MAP kinase phosphatase 2
Short name:
MKP-2
Gene namesi
Name:Dusp4
Synonyms:Mkp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620625. Dusp4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Dual specificity protein phosphatase 4PRO_0000094800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei387 – 3871Phosphoserine; by MAPKBy similarity
Modified residuei392 – 3921Phosphoserine; by MAPKBy similarity

Post-translational modificationi

Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62767.
PRIDEiQ62767.

PTM databases

PhosphoSiteiQ62767.

Expressioni

Tissue specificityi

Expressed at moderate levels in nearly all tissues and cells including brain, spleen, and testes with the higher expression in the heart and lung and lower expression in skeletal muscle and kidney. Undetectable in liver. Expressed in many areas of the brain with very strong expression in the hippocampus, piriform cortex, and the suprachiasmatic nucleus.

Inductioni

By mitogens and by stress.

Gene expression databases

GenevestigatoriQ62767.

Interactioni

Subunit structurei

Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016328.

Structurei

3D structure databases

ProteinModelPortaliQ62767.
SMRiQ62767. Positions 194-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 160119RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini198 – 395198Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000294080.
HOVERGENiHBG007347.
InParanoidiQ62767.
KOiK04459.
PhylomeDBiQ62767.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62767-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTMEELREM DCSVLKRLMN RDENGGTAGS SGGSHGALGL LSGGKCLLLD
60 70 80 90 100
CRPFLAHSAG YIRGSVNVRC NTIVRRRAKG SVSLEQILPA EEEVRARLRS
110 120 130 140 150
GLYSAVIVYD ERSPRAESLR EDSTVSLVVQ ALRRNAERTD ICLLKGGYER
160 170 180 190 200
FSSEYPEFCS KTKALAAIPP PVPPSTNESL DLGCSSCGTP LHDQGGPVEI
210 220 230 240 250
LPFLYLGSAY HAARRDMLDA LGITALLNVS SDCPNHFEGH YQYKCIPVED
260 270 280 290 300
NHKADISSWF MEAIEYIDAV KDCRGRVLVH CQAGISRSAT ICLAYLMMKK
310 320 330 340 350
RVRLEEAFEF VKQRRSIISP NFSFMGQLLQ FESQVLTTSC AAEAASPSGP
360 370 380 390
LRERGKATPT PTSQFVFSFP VSVGVHAAPS NLPYLHSPIT TSPSC
Length:395
Mass (Da):43,187
Last modified:November 1, 1996 - v1
Checksum:iA90EFFD378A050FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23438 mRNA. Translation: AAC52493.1.
RefSeqiNP_071535.1. NM_022199.1.
UniGeneiRn.44407.

Genome annotation databases

GeneIDi60587.
KEGGirno:60587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23438 mRNA. Translation: AAC52493.1 .
RefSeqi NP_071535.1. NM_022199.1.
UniGenei Rn.44407.

3D structure databases

ProteinModelPortali Q62767.
SMRi Q62767. Positions 194-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016328.

PTM databases

PhosphoSitei Q62767.

Proteomic databases

PaxDbi Q62767.
PRIDEi Q62767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 60587.
KEGGi rno:60587.

Organism-specific databases

CTDi 1846.
RGDi 620625. Dusp4.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000294080.
HOVERGENi HBG007347.
InParanoidi Q62767.
KOi K04459.
PhylomeDBi Q62767.

Miscellaneous databases

NextBioi 612322.
PROi Q62767.

Gene expression databases

Genevestigatori Q62767.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation."
    Misra-Press A., Rim C.S., Yao H., Roberson M.S., Stork P.J.S.
    J. Biol. Chem. 270:14587-14596(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.

Entry informationi

Entry nameiDUS4_RAT
AccessioniPrimary (citable) accession number: Q62767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3