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Q62763

- KC1G3_RAT

UniProt

Q62763 - KC1G3_RAT

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Protein
Casein kinase I isoform gamma-3
Gene
Csnk1g3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATP By similarity
Binding sitei117 – 1171Inhibitor triazolodiamine 1; via carbonyl oxygen By similarity
Binding sitei119 – 1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygen By similarity
Active sitei162 – 1621Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. glycoprotein binding Source: RGD
  3. magnesium ion binding Source: RGD
  4. peptide binding Source: RGD
  5. phosphoprotein binding Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. protein autophosphorylation Source: RGD
  3. protein phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
Gene namesi
Name:Csnk1g3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621408. Csnk1g3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Casein kinase I isoform gamma-3
PRO_0000192847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei414 – 4141Phosphoserine By similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62763.
PRIDEiQ62763.

PTM databases

PhosphoSiteiQ62763.

Expressioni

Tissue specificityi

Expressed in testis, brain, heart, kidney, lung, liver and muscle.

Gene expression databases

GenevestigatoriQ62763.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi249201. 1 interaction.
STRINGi10116.ENSRNOP00000022792.

Structurei

3D structure databases

ProteinModelPortaliQ62763.
SMRiQ62763. Positions 36-334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 313271Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiQ62763.
KOiK08958.
OrthoDBiEOG7G1V66.
PhylomeDBiQ62763.
TreeFamiTF313349.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62763-1 [UniParc]FASTAAdd to Basket

« Hide

MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG    50
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP 100
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM 150
EYVHSKNLIY RDVKPENFLI GRPGNKAQQV IHIIDFGLAK EYIDPETKKH 200
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ 250
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 300
DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA 350
HQHRDKIQQS KNQSADHRAA WDSQQANPHH LRAHLAADRH GGSVQVVSST 400
NGELNTDDPT AGRSNAPITA PTEVEVMDET KCCCFFKRRK RKTIQRHK 448
Length:448
Mass (Da):51,429
Last modified:November 1, 1996 - v1
Checksum:i6065DEC2D98B3087
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22321 mRNA. Translation: AAC52202.1.
PIRiC56711.
RefSeqiNP_074046.1. NM_022855.2.
UniGeneiRn.10084.

Genome annotation databases

GeneIDi64823.
KEGGirno:64823.
UCSCiRGD:621408. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22321 mRNA. Translation: AAC52202.1 .
PIRi C56711.
RefSeqi NP_074046.1. NM_022855.2.
UniGenei Rn.10084.

3D structure databases

ProteinModelPortali Q62763.
SMRi Q62763. Positions 36-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249201. 1 interaction.
STRINGi 10116.ENSRNOP00000022792.

Chemistry

BindingDBi Q62763.

PTM databases

PhosphoSitei Q62763.

Proteomic databases

PaxDbi Q62763.
PRIDEi Q62763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64823.
KEGGi rno:64823.
UCSCi RGD:621408. rat.

Organism-specific databases

CTDi 1456.
RGDi 621408. Csnk1g3.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000182054.
HOVERGENi HBG000176.
InParanoidi Q62763.
KOi K08958.
OrthoDBi EOG7G1V66.
PhylomeDBi Q62763.
TreeFami TF313349.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5301.

Miscellaneous databases

NextBioi 613722.
PROi Q62763.

Gene expression databases

Genevestigatori Q62763.

Family and domain databases

InterProi IPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
    Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
    J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKC1G3_RAT
AccessioniPrimary (citable) accession number: Q62763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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