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Q62763

- KC1G3_RAT

UniProt

Q62763 - KC1G3_RAT

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Protein

Casein kinase I isoform gamma-3

Gene

Csnk1g3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotation
Binding sitei117 – 1171Inhibitor triazolodiamine 1; via carbonyl oxygenBy similarity
Binding sitei119 – 1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. glycoprotein binding Source: RGD
  3. magnesium ion binding Source: RGD
  4. peptide binding Source: RGD
  5. phosphoprotein binding Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. protein autophosphorylation Source: RGD
  2. protein phosphorylation Source: RGD
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
Gene namesi
Name:Csnk1g3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621408. Csnk1g3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Casein kinase I isoform gamma-3PRO_0000192847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei414 – 4141PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62763.
PRIDEiQ62763.

PTM databases

PhosphoSiteiQ62763.

Expressioni

Tissue specificityi

Expressed in testis, brain, heart, kidney, lung, liver and muscle.

Gene expression databases

GenevestigatoriQ62763.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi249201. 1 interaction.
STRINGi10116.ENSRNOP00000022792.

Structurei

3D structure databases

ProteinModelPortaliQ62763.
SMRiQ62763. Positions 36-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 313271Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiQ62763.
KOiK08958.
OrthoDBiEOG7G1V66.
PhylomeDBiQ62763.
TreeFamiTF313349.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62763-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG
60 70 80 90 100
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP
110 120 130 140 150
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM
160 170 180 190 200
EYVHSKNLIY RDVKPENFLI GRPGNKAQQV IHIIDFGLAK EYIDPETKKH
210 220 230 240 250
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ
260 270 280 290 300
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP
310 320 330 340 350
DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA
360 370 380 390 400
HQHRDKIQQS KNQSADHRAA WDSQQANPHH LRAHLAADRH GGSVQVVSST
410 420 430 440
NGELNTDDPT AGRSNAPITA PTEVEVMDET KCCCFFKRRK RKTIQRHK
Length:448
Mass (Da):51,429
Last modified:November 1, 1996 - v1
Checksum:i6065DEC2D98B3087
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22321 mRNA. Translation: AAC52202.1.
PIRiC56711.
RefSeqiNP_074046.1. NM_022855.2.
UniGeneiRn.10084.

Genome annotation databases

GeneIDi64823.
KEGGirno:64823.
UCSCiRGD:621408. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22321 mRNA. Translation: AAC52202.1 .
PIRi C56711.
RefSeqi NP_074046.1. NM_022855.2.
UniGenei Rn.10084.

3D structure databases

ProteinModelPortali Q62763.
SMRi Q62763. Positions 36-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249201. 1 interaction.
STRINGi 10116.ENSRNOP00000022792.

PTM databases

PhosphoSitei Q62763.

Proteomic databases

PaxDbi Q62763.
PRIDEi Q62763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64823.
KEGGi rno:64823.
UCSCi RGD:621408. rat.

Organism-specific databases

CTDi 1456.
RGDi 621408. Csnk1g3.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000182054.
HOVERGENi HBG000176.
InParanoidi Q62763.
KOi K08958.
OrthoDBi EOG7G1V66.
PhylomeDBi Q62763.
TreeFami TF313349.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5301.

Miscellaneous databases

NextBioi 613722.
PROi Q62763.

Gene expression databases

Genevestigatori Q62763.

Family and domain databases

InterProi IPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
    Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
    J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKC1G3_RAT
AccessioniPrimary (citable) accession number: Q62763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3