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Q62763

- KC1G3_RAT

UniProt

Q62763 - KC1G3_RAT

Protein

Casein kinase I isoform gamma-3

Gene

Csnk1g3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPPROSITE-ProRule annotation
    Binding sitei117 – 1171Inhibitor triazolodiamine 1; via carbonyl oxygenBy similarity
    Binding sitei119 – 1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: RGD
    2. glycoprotein binding Source: RGD
    3. magnesium ion binding Source: RGD
    4. peptide binding Source: RGD
    5. phosphoprotein binding Source: RGD
    6. protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. protein autophosphorylation Source: RGD
    2. protein phosphorylation Source: RGD
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform gamma-3 (EC:2.7.11.1)
    Short name:
    CKI-gamma 3
    Gene namesi
    Name:Csnk1g3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621408. Csnk1g3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Casein kinase I isoform gamma-3PRO_0000192847Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei414 – 4141PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ62763.
    PRIDEiQ62763.

    PTM databases

    PhosphoSiteiQ62763.

    Expressioni

    Tissue specificityi

    Expressed in testis, brain, heart, kidney, lung, liver and muscle.

    Gene expression databases

    GenevestigatoriQ62763.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi249201. 1 interaction.
    STRINGi10116.ENSRNOP00000022792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62763.
    SMRiQ62763. Positions 36-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 313271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000182054.
    HOVERGENiHBG000176.
    InParanoidiQ62763.
    KOiK08958.
    OrthoDBiEOG7G1V66.
    PhylomeDBiQ62763.
    TreeFamiTF313349.

    Family and domain databases

    InterProiIPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62763-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG    50
    CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP 100
    QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM 150
    EYVHSKNLIY RDVKPENFLI GRPGNKAQQV IHIIDFGLAK EYIDPETKKH 200
    IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ 250
    GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 300
    DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA 350
    HQHRDKIQQS KNQSADHRAA WDSQQANPHH LRAHLAADRH GGSVQVVSST 400
    NGELNTDDPT AGRSNAPITA PTEVEVMDET KCCCFFKRRK RKTIQRHK 448
    Length:448
    Mass (Da):51,429
    Last modified:November 1, 1996 - v1
    Checksum:i6065DEC2D98B3087
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22321 mRNA. Translation: AAC52202.1.
    PIRiC56711.
    RefSeqiNP_074046.1. NM_022855.2.
    UniGeneiRn.10084.

    Genome annotation databases

    GeneIDi64823.
    KEGGirno:64823.
    UCSCiRGD:621408. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22321 mRNA. Translation: AAC52202.1 .
    PIRi C56711.
    RefSeqi NP_074046.1. NM_022855.2.
    UniGenei Rn.10084.

    3D structure databases

    ProteinModelPortali Q62763.
    SMRi Q62763. Positions 36-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249201. 1 interaction.
    STRINGi 10116.ENSRNOP00000022792.

    Chemistry

    BindingDBi Q62763.

    PTM databases

    PhosphoSitei Q62763.

    Proteomic databases

    PaxDbi Q62763.
    PRIDEi Q62763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64823.
    KEGGi rno:64823.
    UCSCi RGD:621408. rat.

    Organism-specific databases

    CTDi 1456.
    RGDi 621408. Csnk1g3.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000182054.
    HOVERGENi HBG000176.
    InParanoidi Q62763.
    KOi K08958.
    OrthoDBi EOG7G1V66.
    PhylomeDBi Q62763.
    TreeFami TF313349.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5301.

    Miscellaneous databases

    NextBioi 613722.
    PROi Q62763.

    Gene expression databases

    Genevestigatori Q62763.

    Family and domain databases

    InterProi IPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
      Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
      J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiKC1G3_RAT
    AccessioniPrimary (citable) accession number: Q62763
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3