Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62763 (KC1G3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Casein kinase I isoform gamma-3

Short name=CKI-gamma 3
EC=2.7.11.1
Gene names
Name:Csnk1g3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in testis, brain, heart, kidney, lung, liver and muscle.

Post-translational modification

Autophosphorylated.

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Sequence similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Casein kinase I isoform gamma-3
PRO_0000192847

Regions

Domain43 – 313271Protein kinase
Nucleotide binding49 – 579ATP By similarity

Sites

Active site1621Proton acceptor By similarity
Binding site721ATP By similarity
Binding site1171Inhibitor triazolodiamine 1; via carbonyl oxygen By similarity
Binding site1191Inhibitor triazolodiamine 1; via amide nitrogen and carbonyl oxygen By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4141Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62763 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6065DEC2D98B3087

FASTA44851,429
        10         20         30         40         50         60 
MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 

        70         80         90        100        110        120 
KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 

       130        140        150        160        170        180 
PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKAQQV 

       190        200        210        220        230        240 
IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 

       250        260        270        280        290        300 
YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 

       310        320        330        340        350        360 
DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA HQHRDKIQQS 

       370        380        390        400        410        420 
KNQSADHRAA WDSQQANPHH LRAHLAADRH GGSVQVVSST NGELNTDDPT AGRSNAPITA 

       430        440 
PTEVEVMDET KCCCFFKRRK RKTIQRHK 

« Hide

References

[1]"Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22321 mRNA. Translation: AAC52202.1.
PIRC56711.
RefSeqNP_074046.1. NM_022855.2.
UniGeneRn.10084.

3D structure databases

ProteinModelPortalQ62763.
SMRQ62763. Positions 36-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249201. 1 interaction.
STRING10116.ENSRNOP00000022792.

Chemistry

BindingDBQ62763.

PTM databases

PhosphoSiteQ62763.

Proteomic databases

PaxDbQ62763.
PRIDEQ62763.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID64823.
KEGGrno:64823.
UCSCRGD:621408. rat.

Organism-specific databases

CTD1456.
RGD621408. Csnk1g3.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000182054.
HOVERGENHBG000176.
InParanoidQ62763.
KOK08958.
OrthoDBEOG7G1V66.
PhylomeDBQ62763.
TreeFamTF313349.

Enzyme and pathway databases

BRENDA2.7.11.1. 5301.

Gene expression databases

GenevestigatorQ62763.

Family and domain databases

InterProIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613722.
PROQ62763.

Entry information

Entry nameKC1G3_RAT
AccessionPrimary (citable) accession number: Q62763
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families