Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62762

- KC1G2_RAT

UniProt

Q62762 - KC1G2_RAT

Protein

Casein kinase I isoform gamma-2

Gene

Csnk1g2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Stimulated by estrogen.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751ATPPROSITE-ProRule annotation
    Active sitei165 – 1651Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi52 – 609ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: RGD
    2. glycoprotein binding Source: RGD
    3. magnesium ion binding Source: RGD
    4. peptide binding Source: RGD
    5. phosphoprotein binding Source: RGD
    6. protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. protein autophosphorylation Source: RGD
    2. protein phosphorylation Source: RGD
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5301.
    ReactomeiREACT_196736. Sphingolipid de novo biosynthesis.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform gamma-2 (EC:2.7.11.1)
    Short name:
    CKI-gamma 2
    Gene namesi
    Name:Csnk1g2
    Synonyms:Ck1g2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi621407. Csnk1g2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Casein kinase I isoform gamma-2PRO_0000192844Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ62762.
    PRIDEiQ62762.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiQ62762.
    GenevestigatoriQ62762.

    Interactioni

    Subunit structurei

    Monomer. Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62762.
    SMRiQ62762. Positions 39-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 316271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110718.
    HOGENOMiHOG000182054.
    HOVERGENiHBG000176.
    KOiK08958.
    OMAiHRNTHEP.
    OrthoDBiEOG7G1V66.
    PhylomeDBiQ62762.

    Family and domain databases

    InterProiIPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFDKKGGKG ELEEGRRMSK TGTNRSNHGV RNSGTSSGVL MVGPNFRVGK    50
    KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSTTE 100
    GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI 150
    TRMEYVHTKS LIYRDVKPEN FLVGRPGSKR QHSIHIIDFG LAKEYIDPET 200
    KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL 250
    PWQGLKADTL KERYQKIGDT KRATPIEVLC ESFPEEMATY LRYVRRLDFF 300
    EKPDYDYLRK LFTDLFDRSG YVFDYEYDWA GKPLPTPIGT VHPDVPSQPP 350
    HRDKAQLHTK NQALNSTNGE LNTDDPTAGH SNAPIAAPAE VEVADETKCC 400
    CFFKRRKRKS LQRHK 415
    Length:415
    Mass (Da):47,636
    Last modified:October 11, 2004 - v2
    Checksum:i6BE480CE200FBEBB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 602EL → DV in AAC52201. (PubMed:7759525)Curated
    Sequence conflicti100 – 1001Missing in AAC52201. (PubMed:7759525)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22297 mRNA. Translation: AAC52201.1.
    BC072533 mRNA. Translation: AAH72533.1.
    PIRiB56711.
    RefSeqiNP_001029042.1. NM_001033870.1.
    NP_075590.2. NM_023102.2.
    XP_006241064.1. XM_006241002.1.
    UniGeneiRn.98151.

    Genome annotation databases

    EnsembliENSRNOT00000025266; ENSRNOP00000025266; ENSRNOG00000018529.
    GeneIDi65278.
    KEGGirno:65278.
    UCSCiRGD:621407. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22297 mRNA. Translation: AAC52201.1 .
    BC072533 mRNA. Translation: AAH72533.1 .
    PIRi B56711.
    RefSeqi NP_001029042.1. NM_001033870.1.
    NP_075590.2. NM_023102.2.
    XP_006241064.1. XM_006241002.1.
    UniGenei Rn.98151.

    3D structure databases

    ProteinModelPortali Q62762.
    SMRi Q62762. Positions 39-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022473.

    Proteomic databases

    PaxDbi Q62762.
    PRIDEi Q62762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025266 ; ENSRNOP00000025266 ; ENSRNOG00000018529 .
    GeneIDi 65278.
    KEGGi rno:65278.
    UCSCi RGD:621407. rat.

    Organism-specific databases

    CTDi 1455.
    RGDi 621407. Csnk1g2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110718.
    HOGENOMi HOG000182054.
    HOVERGENi HBG000176.
    KOi K08958.
    OMAi HRNTHEP.
    OrthoDBi EOG7G1V66.
    PhylomeDBi Q62762.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5301.
    Reactomei REACT_196736. Sphingolipid de novo biosynthesis.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 614248.

    Gene expression databases

    ArrayExpressi Q62762.
    Genevestigatori Q62762.

    Family and domain databases

    InterProi IPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
      Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
      J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiKC1G2_RAT
    AccessioniPrimary (citable) accession number: Q62762
    Secondary accession number(s): Q6IMY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3