Casein kinase I isoform gamma-2 - Rattus norvegicus (Rat)

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Q62762 (KC1G2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Casein kinase I isoform gamma-2
Short name=CKI-gamma 2
EC=2.7.11.1

Gene names

Name:	Csnk1g2
Synonyms:	Ck1g2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Stimulated by estrogen By similarity.
Subunit structure	Monomer. Binds to PER1 and triggers its proteasomal degradation. Interacts with SMAD3. Interacts with MTA1 (short isoform) in the cytoplasm By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Testis.
Post-translational modification	Autophosphorylated.
Sequence similarities	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW protein autophosphorylation Inferred from direct assay Ref.1. Source: RGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from direct assay Ref.1. Source: RGD glycoprotein binding Inferred from direct assay Ref.1. Source: RGD magnesium ion binding Inferred from direct assay Ref.1. Source: RGD peptide binding Inferred from direct assay Ref.1. Source: RGD phosphoprotein binding Inferred from direct assay Ref.1. Source: RGD protein serine/threonine kinase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 415

415

Casein kinase I isoform gamma-2

PRO_0000192844

Regions

Domain

46 – 316

271

Protein kinase

Nucleotide binding

52 – 60

ATP By similarity

Sites

Active site

165

Proton acceptor By similarity

Binding site

ATP By similarity

Experimental info

Sequence conflict

59 – 60

EL → DV in AAC52201. Ref.1

Sequence conflict

100

Missing in AAC52201. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q62762 [UniParc].

Last modified October 11, 2004. Version 2.
Checksum: 6BE480CE200FBEBB
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FASTA

415

47,636

        10         20         30         40         50         60 
MDFDKKGGKG ELEEGRRMSK TGTNRSNHGV RNSGTSSGVL MVGPNFRVGK KIGCGNFGEL 

        70         80         90        100        110        120 
RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSTTE GVPQVYYFGP CGKYNAMVLE 

       130        140        150        160        170        180 
LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGSKR 

       190        200        210        220        230        240 
QHSIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH 

       250        260        270        280        290        300 
MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ESFPEEMATY LRYVRRLDFF 

       310        320        330        340        350        360 
EKPDYDYLRK LFTDLFDRSG YVFDYEYDWA GKPLPTPIGT VHPDVPSQPP HRDKAQLHTK 

       370        380        390        400        410 
NQALNSTNGE LNTDDPTAGH SNAPIAAPAE VEVADETKCC CFFKRRKRKS LQRHK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes." Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J. J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U22297 mRNA. Translation: AAC52201.1. BC072533 mRNA. Translation: AAH72533.1.
IPI	IPI00230964.
PIR	B56711.
RefSeq	NP_001029042.1. NM_001033870.1. NP_075590.2. NM_023102.2.
UniGene	Rn.98151.
3D structure databases
ProteinModelPortal	Q62762.
SMR	Q62762. Positions 39-337.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022473.
Proteomic databases
PaxDb	Q62762.
PRIDE	Q62762.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025266; ENSRNOP00000025266; ENSRNOG00000018529.
GeneID	65278.
KEGG	rno:65278.
UCSC	RGD:621407. rat.
Organism-specific databases
CTD	1455.
RGD	621407. Csnk1g2.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076651.
HOGENOM	HOG000182054.
HOVERGEN	HBG000176.
KO	K08958.
Enzyme and pathway databases
BRENDA	2.7.11.1. 5301.
Gene expression databases
ArrayExpress	Q62762.
Genevestigator	Q62762.
GermOnline	ENSRNOG00000018529. Rattus norvegicus.
Family and domain databases
InterPro	IPR022247. Casein_kinase-1_gamma_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF12605. CK1gamma_C. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	614248.

Entry information

Entry name

KC1G2_RAT

Accession

Primary (citable) accession number: Q62762
Secondary accession number(s): Q6IMY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents