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Q62762

- KC1G2_RAT

UniProt

Q62762 - KC1G2_RAT

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Protein
Casein kinase I isoform gamma-2
Gene
Csnk1g2, Ck1g2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Stimulated by estrogen By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751ATP By similarity
Active sitei165 – 1651Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi52 – 609ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. glycoprotein binding Source: RGD
  3. magnesium ion binding Source: RGD
  4. peptide binding Source: RGD
  5. phosphoprotein binding Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. protein autophosphorylation Source: RGD
  3. protein phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.
ReactomeiREACT_196736. Sphingolipid de novo biosynthesis.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-2 (EC:2.7.11.1)
Short name:
CKI-gamma 2
Gene namesi
Name:Csnk1g2
Synonyms:Ck1g2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621407. Csnk1g2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Casein kinase I isoform gamma-2
PRO_0000192844Add
BLAST

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62762.
PRIDEiQ62762.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

ArrayExpressiQ62762.
GenevestigatoriQ62762.

Interactioni

Subunit structurei

Monomer. Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022473.

Structurei

3D structure databases

ProteinModelPortaliQ62762.
SMRiQ62762. Positions 39-337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 316271Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110718.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
KOiK08958.
OMAiHRNTHEP.
OrthoDBiEOG7G1V66.
PhylomeDBiQ62762.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62762-1 [UniParc]FASTAAdd to Basket

« Hide

MDFDKKGGKG ELEEGRRMSK TGTNRSNHGV RNSGTSSGVL MVGPNFRVGK    50
KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSTTE 100
GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI 150
TRMEYVHTKS LIYRDVKPEN FLVGRPGSKR QHSIHIIDFG LAKEYIDPET 200
KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL 250
PWQGLKADTL KERYQKIGDT KRATPIEVLC ESFPEEMATY LRYVRRLDFF 300
EKPDYDYLRK LFTDLFDRSG YVFDYEYDWA GKPLPTPIGT VHPDVPSQPP 350
HRDKAQLHTK NQALNSTNGE LNTDDPTAGH SNAPIAAPAE VEVADETKCC 400
CFFKRRKRKS LQRHK 415
Length:415
Mass (Da):47,636
Last modified:October 11, 2004 - v2
Checksum:i6BE480CE200FBEBB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 602EL → DV in AAC52201. 1 Publication
Sequence conflicti100 – 1001Missing in AAC52201. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22297 mRNA. Translation: AAC52201.1.
BC072533 mRNA. Translation: AAH72533.1.
PIRiB56711.
RefSeqiNP_001029042.1. NM_001033870.1.
NP_075590.2. NM_023102.2.
XP_006241064.1. XM_006241002.1.
UniGeneiRn.98151.

Genome annotation databases

EnsembliENSRNOT00000025266; ENSRNOP00000025266; ENSRNOG00000018529.
GeneIDi65278.
KEGGirno:65278.
UCSCiRGD:621407. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22297 mRNA. Translation: AAC52201.1 .
BC072533 mRNA. Translation: AAH72533.1 .
PIRi B56711.
RefSeqi NP_001029042.1. NM_001033870.1.
NP_075590.2. NM_023102.2.
XP_006241064.1. XM_006241002.1.
UniGenei Rn.98151.

3D structure databases

ProteinModelPortali Q62762.
SMRi Q62762. Positions 39-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022473.

Proteomic databases

PaxDbi Q62762.
PRIDEi Q62762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025266 ; ENSRNOP00000025266 ; ENSRNOG00000018529 .
GeneIDi 65278.
KEGGi rno:65278.
UCSCi RGD:621407. rat.

Organism-specific databases

CTDi 1455.
RGDi 621407. Csnk1g2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110718.
HOGENOMi HOG000182054.
HOVERGENi HBG000176.
KOi K08958.
OMAi HRNTHEP.
OrthoDBi EOG7G1V66.
PhylomeDBi Q62762.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5301.
Reactomei REACT_196736. Sphingolipid de novo biosynthesis.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 614248.

Gene expression databases

ArrayExpressi Q62762.
Genevestigatori Q62762.

Family and domain databases

InterProi IPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
    Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
    J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiKC1G2_RAT
AccessioniPrimary (citable) accession number: Q62762
Secondary accession number(s): Q6IMY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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