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Q62761

- KC1G1_RAT

UniProt

Q62761 - KC1G1_RAT

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Protein

Casein kinase I isoform gamma-1

Gene
Csnk1g1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731ATP By similarity
Active sitei164 – 1641Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 589ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. glycoprotein binding Source: RGD
  3. magnesium ion binding Source: RGD
  4. peptide binding Source: RGD
  5. phosphoprotein binding Source: RGD
  6. protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. protein autophosphorylation Source: RGD
  2. protein phosphorylation Source: RGD
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-1 (EC:2.7.11.1)
Short name:
CKI-gamma 1
Gene namesi
Name:Csnk1g1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi621404. Csnk1g1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Casein kinase I isoform gamma-1PRO_0000192841Add
BLAST

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62761.
PRIDEiQ62761.

Expressioni

Gene expression databases

GenevestigatoriQ62761.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi248970. 1 interaction.
STRINGi10116.ENSRNOP00000022391.

Structurei

3D structure databases

ProteinModelPortaliQ62761.
SMRiQ62761. Positions 45-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 315272Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110718.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
KOiK08958.
OMAiRDRPSQH.
OrthoDBiEOG7G1V66.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62761-1 [UniParc]FASTAAdd to Basket

« Hide

MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI    50
GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG 100
LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS 150
RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYIDPETK 200
KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP 250
WQGLKADTLK ERYQKIGDTK RSTPIEALCE NFPEEMMTYL RYVRRLDFFE 300
KPDYEYLRNL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT 350
RESHTHRDRP SQQQPLRNQP RSLTAEWFVL APLSHPPAPT 390
Length:390
Mass (Da):45,127
Last modified:November 1, 1996 - v1
Checksum:i8B9D8F5952D40762
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22296 mRNA. Translation: AAC52200.1.
BC078831 mRNA. Translation: AAH78831.1.
PIRiA56711.
RefSeqiNP_071624.1. NM_022288.1.
UniGeneiRn.10082.

Genome annotation databases

EnsembliENSRNOT00000042369; ENSRNOP00000048274; ENSRNOG00000016620.
GeneIDi64086.
KEGGirno:64086.
UCSCiRGD:621404. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22296 mRNA. Translation: AAC52200.1 .
BC078831 mRNA. Translation: AAH78831.1 .
PIRi A56711.
RefSeqi NP_071624.1. NM_022288.1.
UniGenei Rn.10082.

3D structure databases

ProteinModelPortali Q62761.
SMRi Q62761. Positions 45-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248970. 1 interaction.
STRINGi 10116.ENSRNOP00000022391.

Chemistry

BindingDBi Q62761.

Proteomic databases

PaxDbi Q62761.
PRIDEi Q62761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000042369 ; ENSRNOP00000048274 ; ENSRNOG00000016620 .
GeneIDi 64086.
KEGGi rno:64086.
UCSCi RGD:621404. rat.

Organism-specific databases

CTDi 53944.
RGDi 621404. Csnk1g1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110718.
HOGENOMi HOG000182054.
HOVERGENi HBG000176.
KOi K08958.
OMAi RDRPSQH.
OrthoDBi EOG7G1V66.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5301.

Miscellaneous databases

NextBioi 612737.

Gene expression databases

Genevestigatori Q62761.

Family and domain databases

InterProi IPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
    Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
    J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKC1G1_RAT
AccessioniPrimary (citable) accession number: Q62761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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