Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62761 (KC1G1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Casein kinase I isoform gamma-1

Short name=CKI-gamma 1
EC=2.7.11.1
Gene names
Name:Csnk1g1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm.

Post-translational modification

Autophosphorylated.

Sequence similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Casein kinase I isoform gamma-1
PRO_0000192841

Regions

Domain44 – 315272Protein kinase
Nucleotide binding50 – 589ATP By similarity

Sites

Active site1641Proton acceptor By similarity
Binding site731ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62761 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8B9D8F5952D40762

FASTA39045,127
        10         20         30         40         50         60 
MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI GCGNFGELRL 

        70         80         90        100        110        120 
GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 

       130        140        150        160        170        180 
LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 

       190        200        210        220        230        240 
HVIHIIDFGL AKEYIDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 

       250        260        270        280        290        300 
FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RSTPIEALCE NFPEEMMTYL RYVRRLDFFE 

       310        320        330        340        350        360 
KPDYEYLRNL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 

       370        380        390 
SQQQPLRNQP RSLTAEWFVL APLSHPPAPT 

« Hide

References

« Hide 'large scale' references
[1]"Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22296 mRNA. Translation: AAC52200.1.
BC078831 mRNA. Translation: AAH78831.1.
PIRA56711.
RefSeqNP_071624.1. NM_022288.1.
UniGeneRn.10082.

3D structure databases

ProteinModelPortalQ62761.
SMRQ62761. Positions 45-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248970. 1 interaction.
STRING10116.ENSRNOP00000022391.

Chemistry

BindingDBQ62761.

Proteomic databases

PaxDbQ62761.
PRIDEQ62761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000042369; ENSRNOP00000048274; ENSRNOG00000016620.
GeneID64086.
KEGGrno:64086.
UCSCRGD:621404. rat.

Organism-specific databases

CTD53944.
RGD621404. Csnk1g1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110718.
HOGENOMHOG000182054.
HOVERGENHBG000176.
KOK08958.
OMARDRPSQH.
OrthoDBEOG7G1V66.

Enzyme and pathway databases

BRENDA2.7.11.1. 5301.

Gene expression databases

GenevestigatorQ62761.

Family and domain databases

InterProIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612737.

Entry information

Entry nameKC1G1_RAT
AccessionPrimary (citable) accession number: Q62761
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families