Casein kinase I isoform gamma-1 - Rattus norvegicus (Rat)

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Q62761 (KC1G1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Casein kinase I isoform gamma-1
Short name=CKI-gamma 1
EC=2.7.11.1

Gene names

Name:

Csnk1g1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm.
Post-translational modification	Autophosphorylated.
Sequence similarities	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW protein autophosphorylation Inferred from direct assay Ref.1. Source: RGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from direct assay Ref.1. Source: RGD glycoprotein binding Inferred from direct assay Ref.1. Source: RGD magnesium ion binding Inferred from direct assay Ref.1. Source: RGD peptide binding Inferred from direct assay Ref.1. Source: RGD phosphoprotein binding Inferred from direct assay Ref.1. Source: RGD protein serine/threonine kinase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 390

390

Casein kinase I isoform gamma-1

PRO_0000192841

Regions

Domain

44 – 315

272

Protein kinase

Nucleotide binding

50 – 58

ATP By similarity

Sites

Active site

164

Proton acceptor By similarity

Binding site

ATP By similarity

Amino acid modifications

Modified residue

344

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q62761 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8B9D8F5952D40762
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FASTA

390

45,127

        10         20         30         40         50         60 
MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI GCGNFGELRL 

        70         80         90        100        110        120 
GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 

       130        140        150        160        170        180 
LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 

       190        200        210        220        230        240 
HVIHIIDFGL AKEYIDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 

       250        260        270        280        290        300 
FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RSTPIEALCE NFPEEMMTYL RYVRRLDFFE 

       310        320        330        340        350        360 
KPDYEYLRNL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 

       370        380        390 
SQQQPLRNQP RSLTAEWFVL APLSHPPAPT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes." Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J. J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U22296 mRNA. Translation: AAC52200.1. BC078831 mRNA. Translation: AAH78831.1.
IPI	IPI00208211.
PIR	A56711.
RefSeq	NP_071624.1. NM_022288.1.
UniGene	Rn.10082.
3D structure databases
ProteinModelPortal	Q62761.
SMR	Q62761. Positions 45-339.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022391.
Proteomic databases
PaxDb	Q62761.
PRIDE	Q62761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000042369; ENSRNOP00000048274; ENSRNOG00000016620.
GeneID	64086.
KEGG	rno:64086.
UCSC	RGD:621404. rat.
Organism-specific databases
CTD	53944.
RGD	621404. Csnk1g1.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076651.
HOGENOM	HOG000182054.
HOVERGEN	HBG000176.
KO	K08958.
Enzyme and pathway databases
BRENDA	2.7.11.1. 5301.
Gene expression databases
ArrayExpress	Q62761.
Genevestigator	Q62761.
GermOnline	ENSRNOG00000016620. Rattus norvegicus.
Family and domain databases
InterPro	IPR022247. Casein_kinase-1_gamma_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF12605. CK1gamma_C. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q62761.
ChEMBL	CHEMBL5561.
NextBio	612737.

Entry information

Entry name

KC1G1_RAT

Accession

Primary (citable) accession number: Q62761

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents