Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62761

- KC1G1_RAT

UniProt

Q62761 - KC1G1_RAT

Protein

Casein kinase I isoform gamma-1

Gene

Csnk1g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731ATPPROSITE-ProRule annotation
    Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 589ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: RGD
    2. glycoprotein binding Source: RGD
    3. magnesium ion binding Source: RGD
    4. peptide binding Source: RGD
    5. phosphoprotein binding Source: RGD
    6. protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. protein autophosphorylation Source: RGD
    2. protein phosphorylation Source: RGD
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform gamma-1 (EC:2.7.11.1)
    Short name:
    CKI-gamma 1
    Gene namesi
    Name:Csnk1g1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi621404. Csnk1g1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Casein kinase I isoform gamma-1PRO_0000192841Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ62761.
    PRIDEiQ62761.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62761.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi248970. 1 interaction.
    STRINGi10116.ENSRNOP00000022391.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62761.
    SMRiQ62761. Positions 45-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 315272Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110718.
    HOGENOMiHOG000182054.
    HOVERGENiHBG000176.
    KOiK08958.
    OMAiRDRPSQH.
    OrthoDBiEOG7G1V66.

    Family and domain databases

    InterProiIPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI    50
    GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG 100
    LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS 150
    RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYIDPETK 200
    KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP 250
    WQGLKADTLK ERYQKIGDTK RSTPIEALCE NFPEEMMTYL RYVRRLDFFE 300
    KPDYEYLRNL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT 350
    RESHTHRDRP SQQQPLRNQP RSLTAEWFVL APLSHPPAPT 390
    Length:390
    Mass (Da):45,127
    Last modified:November 1, 1996 - v1
    Checksum:i8B9D8F5952D40762
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22296 mRNA. Translation: AAC52200.1.
    BC078831 mRNA. Translation: AAH78831.1.
    PIRiA56711.
    RefSeqiNP_071624.1. NM_022288.1.
    UniGeneiRn.10082.

    Genome annotation databases

    EnsembliENSRNOT00000042369; ENSRNOP00000048274; ENSRNOG00000016620.
    GeneIDi64086.
    KEGGirno:64086.
    UCSCiRGD:621404. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22296 mRNA. Translation: AAC52200.1 .
    BC078831 mRNA. Translation: AAH78831.1 .
    PIRi A56711.
    RefSeqi NP_071624.1. NM_022288.1.
    UniGenei Rn.10082.

    3D structure databases

    ProteinModelPortali Q62761.
    SMRi Q62761. Positions 45-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248970. 1 interaction.
    STRINGi 10116.ENSRNOP00000022391.

    Chemistry

    BindingDBi Q62761.

    Proteomic databases

    PaxDbi Q62761.
    PRIDEi Q62761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000042369 ; ENSRNOP00000048274 ; ENSRNOG00000016620 .
    GeneIDi 64086.
    KEGGi rno:64086.
    UCSCi RGD:621404. rat.

    Organism-specific databases

    CTDi 53944.
    RGDi 621404. Csnk1g1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110718.
    HOGENOMi HOG000182054.
    HOVERGENi HBG000176.
    KOi K08958.
    OMAi RDRPSQH.
    OrthoDBi EOG7G1V66.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5301.

    Miscellaneous databases

    NextBioi 612737.

    Gene expression databases

    Genevestigatori Q62761.

    Family and domain databases

    InterProi IPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes."
      Zhai L., Graves P.R., Robinson L.C., Italiano M., Culbertson M.R., Rowles J., Cobb M.H., Depaoli-Roach A.A., Roach P.J.
      J. Biol. Chem. 270:12717-12724(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiKC1G1_RAT
    AccessioniPrimary (citable) accession number: Q62761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3