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Q62760 (TOM20_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor Tom20
Gene names
Name:Tomm20
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore By similarity.

Subunit structure

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1 By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the Tom20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145Mitochondrial import receptor subunit TOM20 homolog
PRO_0000051541

Regions

Topological domain1 – 66Mitochondrial intermembrane Potential
Transmembrane7 – 2418Helical; Potential
Topological domain25 – 145121Cytoplasmic Potential

Amino acid modifications

Modified residue1351Phosphoserine By similarity
Modified residue1381Phosphoserine By similarity

Experimental info

Sequence conflict121V → L in AAB01506. Ref.1
Sequence conflict301S → G in AAB01506. Ref.1
Sequence conflict361N → D in BAA09714. Ref.2
Sequence conflict1401A → G in BAA09714. Ref.2

Secondary structure

............. 145
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q62760 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 50E3BD25AD5C9B3B

FASTA14516,284
        10         20         30         40         50         60 
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE RAGLSKLPDL 

        70         80         90        100        110        120 
KDAEAVQKFF LEEIQLGEEL LAQGDYEKGV DHLTNAIAVC GQPQQLLQVL QQTLPPPVFQ 

       130        140 
MLLTKLPTIS QRIVSAQSLA EDDVE 

« Hide

References

« Hide 'large scale' references
[1]Nuttall S.D., Sinding J., Hanson B., Hoogenraad N.J.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA cloning and characterization of rat mitochondrial precursor receptor."
Mihara K., Nomura N., Matsuo H., Sakaguchi M.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]"Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20."
Abe Y., Shodai T., Muto T., Mihara K., Torii H., Nishikawa S., Endo T., Kohda D.
Cell 100:551-560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 51-145.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21871 mRNA. Translation: AAB01506.1.
D63411 mRNA. Translation: BAA09714.1.
BC078715 mRNA. Translation: AAH78715.1.
RefSeqNP_690918.1. NM_152935.1.
UniGeneRn.2143.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OM2NMR-A51-145[»]
2V1SX-ray2.05A/B/C/D/E/F/G59-126[»]
2V1TX-ray1.92A/B59-126[»]
3AWRX-ray2.00A/B59-126[»]
3AX2X-ray1.90A/C/E/G59-126[»]
3AX3X-ray2.10A/C/E/G59-126[»]
3AX5X-ray2.20A/C59-126[»]
ProteinModelPortalQ62760.
SMRQ62760. Positions 59-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid251753. 1 interaction.

PTM databases

PhosphoSiteQ62760.

Proteomic databases

PaxDbQ62760.
PRIDEQ62760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027088; ENSRNOP00000027088; ENSRNOG00000019980.
GeneID266601.
KEGGrno:266601.
UCSCRGD:708467. rat.

Organism-specific databases

CTD9804.
RGD708467. Tomm20.

Phylogenomic databases

eggNOGNOG307355.
GeneTreeENSGT00390000011698.
HOGENOMHOG000006671.
HOVERGENHBG057315.
InParanoidQ6AZ66.
KOK17770.
OMAHIANAVM.
OrthoDBEOG790G2R.
PhylomeDBQ62760.
TreeFamTF106200.

Gene expression databases

GenevestigatorQ62760.

Family and domain databases

Gene3D1.20.960.10. 1 hit.
InterProIPR002056. MAS20_rcpt-related.
IPR022422. MAS20_rcpt_metazoan.
IPR023392. Tom20_dom.
[Graphical view]
PANTHERPTHR12430. PTHR12430. 1 hit.
PfamPF02064. MAS20. 1 hit.
[Graphical view]
PIRSFPIRSF037707. MAS20_rcpt. 1 hit.
PRINTSPR01989. EUOM20RECPTR.
PR00351. OM20RECEPTOR.
SUPFAMSSF47157. SSF47157. 1 hit.
TIGRFAMsTIGR00985. 3a0801s04tom. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ62760.
NextBio624408.
PROQ62760.

Entry information

Entry nameTOM20_RAT
AccessionPrimary (citable) accession number: Q62760
Secondary accession number(s): O08517, Q63804, Q6AZ66
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references