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Protein

Oxysterols receptor LXR-beta

Gene

Nr1h2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Exhibits a ligand-dependent transcriptional activation activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi75 – 152Nuclear receptorPROSITE-ProRule annotationAdd BLAST78
Zinc fingeri78 – 98NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri116 – 140NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-8866427. VLDLR internalisation and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-beta
Alternative name(s):
Liver X receptor beta
Nuclear receptor subfamily 1 group H member 2
Orphan nuclear receptor OR-1
Ubiquitously-expressed nuclear receptor
Short name:
UR
Gene namesi
Name:Nr1h2
Synonyms:Lxrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61906. Nr1h2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535341 – 446Oxysterols receptor LXR-betaAdd BLAST446

Proteomic databases

PaxDbiQ62755.

PTM databases

PhosphoSitePlusiQ62755.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019812.
GenevisibleiQ62755. RN.

Interactioni

Subunit structurei

Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.By similarity

GO - Molecular functioni

  • retinoid X receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026862.

Structurei

3D structure databases

ProteinModelPortaliQ62755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 76Transactivation AF-1; required for ligand-independent transactivation functionBy similarityAdd BLAST76
Regioni205 – 446Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2By similarityAdd BLAST242
Regioni216 – 446Ligand-bindingSequence analysisAdd BLAST231

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 168Poly-Gln7
Compositional biasi169 – 172Poly-Pro4

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 98NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri116 – 140NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ62755.
KOiK08535.
OMAiRRYACRG.
OrthoDBiEOG091G0I4P.
PhylomeDBiQ62755.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI
60 70 80 90 100
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG
110 120 130 140 150
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV
160 170 180 190 200
LSEEQIRKKK IQKQQQQQPP PPTEPASGSS ARPAASPGTS EASSQGSGEG
210 220 230 240 250
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ
260 270 280 290 300
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
310 320 330 340 350
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL
360 370 380 390 400
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ
410 420 430 440
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE
Length:446
Mass (Da):49,736
Last modified:November 1, 1996 - v1
Checksum:i13DF6DC2F0F5FA4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33G → V in AAA52361 (PubMed:7971966).Curated1
Sequence conflicti52 – 54Missing in AAA52361 (PubMed:7971966).Curated3
Sequence conflicti219A → V in AAA52361 (PubMed:7971966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20389 mRNA. Translation: AAA69522.1.
U14533 mRNA. Translation: AAA52361.1.
PIRiI59354.
RefSeqiNP_113814.1. NM_031626.1.
UniGeneiRn.786.

Genome annotation databases

EnsembliENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812.
GeneIDi58851.
KEGGirno:58851.
UCSCiRGD:61906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20389 mRNA. Translation: AAA69522.1.
U14533 mRNA. Translation: AAA52361.1.
PIRiI59354.
RefSeqiNP_113814.1. NM_031626.1.
UniGeneiRn.786.

3D structure databases

ProteinModelPortaliQ62755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026862.

PTM databases

PhosphoSitePlusiQ62755.

Proteomic databases

PaxDbiQ62755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812.
GeneIDi58851.
KEGGirno:58851.
UCSCiRGD:61906. rat.

Organism-specific databases

CTDi7376.
RGDi61906. Nr1h2.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ62755.
KOiK08535.
OMAiRRYACRG.
OrthoDBiEOG091G0I4P.
PhylomeDBiQ62755.
TreeFamiTF352167.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-8866427. VLDLR internalisation and degradation.

Miscellaneous databases

PROiQ62755.

Gene expression databases

BgeeiENSRNOG00000019812.
GenevisibleiQ62755. RN.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR1H2_RAT
AccessioniPrimary (citable) accession number: Q62755
Secondary accession number(s): Q62694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.