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Protein

Syntaxin-binding protein 2

Gene

Stxbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity).By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: RGD
  • syntaxin-3 binding Source: RGD
  • syntaxin binding Source: RGD

GO - Biological processi

  • cellular response to interferon-gamma Source: RGD
  • exocytosis Source: RGD
  • leukocyte mediated cytotoxicity Source: RGD
  • neutrophil degranulation Source: RGD
  • positive regulation of mast cell degranulation Source: RGD
  • protein transport Source: UniProtKB-KW
  • regulation of mast cell degranulation Source: RGD
  • response to acidic pH Source: RGD
  • synaptic vesicle exocytosis Source: RGD
  • vesicle docking involved in exocytosis Source: InterPro

Keywordsi

Biological processExocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 2
Alternative name(s):
Protein unc-18 homolog 2
Short name:
Munc18-2
Short name:
Unc18-2
Protein unc-18 homolog B
Short name:
Unc-18B
Gene namesi
Name:Stxbp2
Synonyms:Unc18b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619967 Stxbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062841 – 594Syntaxin-binding protein 2Add BLAST594

Proteomic databases

PaxDbiQ62753
PRIDEiQ62753

PTM databases

iPTMnetiQ62753
PhosphoSitePlusiQ62753

Interactioni

Subunit structurei

Interacts with STX1A, STX2 and STX3. Interacts with STX11.By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: RGD
  • syntaxin-3 binding Source: RGD
  • syntaxin binding Source: RGD

Protein-protein interaction databases

BioGridi2496623 interactors.
DIPiDIP-289N
STRINGi10116.ENSRNOP00000001322

Structurei

3D structure databases

ProteinModelPortaliQ62753
SMRiQ62753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1300 Eukaryota
COG5158 LUCA
HOGENOMiHOG000232146
HOVERGENiHBG052710
InParanoidiQ62753
KOiK15300
PhylomeDBiQ62753

Family and domain databases

Gene3Di3.40.50.19102 hits
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequencei

Sequence statusi: Complete.

Q62753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGLKAVV VEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI
60 70 80 90 100
LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK
110 120 130 140 150
AAHIFFTDTC PEPLFSELGR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP
160 170 180 190 200
HSTYNLYCPF RAGERGRQLD VLAQQIATLC ATLQEYPSIR YRKGPEDTAQ
210 220 230 240 250
LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ
260 270 280 290 300
AMAYDLLHIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
310 320 330 340 350
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA
360 370 380 390 400
DDCMKHFKGS VEKLCGVEQD LAMGSDAEGE KIKDTMKLIV PVLLDASVPP
410 420 430 440 450
YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQSYSNLIRN LEQLGGTVTN
460 470 480 490 500
SAGSGTSSRL ERRERMEPTY QLSRWSPVIK DVMEDVVEDR LDRKLWPFVS
510 520 530 540 550
DPAPVSSSQA AVSSARFGHW HKNKAGIEAR AGPRLIVYIV GGVAMSEMRA
560 570 580 590
AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LRTLDQKLED IALP
Length:594
Mass (Da):66,696
Last modified:November 1, 1996 - v1
Checksum:iB4956372A75F1637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20283 mRNA Translation: AAA79516.1
PIRiA57022
RefSeqiNP_112388.1, NM_031126.1
UniGeneiRn.10121

Genome annotation databases

GeneIDi81804
KEGGirno:81804
UCSCiRGD:619967 rat

Similar proteinsi

Entry informationi

Entry nameiSTXB2_RAT
AccessioniPrimary (citable) accession number: Q62753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome