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Protein

Syntaxin-binding protein 2

Gene

Stxbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity).By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: RGD
  • syntaxin-3 binding Source: RGD
  • syntaxin binding Source: RGD

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • regulation of mast cell degranulation Source: RGD
  • response to acidic pH Source: RGD
  • synaptic vesicle exocytosis Source: RGD
  • vesicle docking involved in exocytosis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 2
Alternative name(s):
Protein unc-18 homolog 2
Short name:
Munc18-2
Short name:
Unc18-2
Protein unc-18 homolog B
Short name:
Unc-18B
Gene namesi
Name:Stxbp2
Synonyms:Unc18b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619967. Stxbp2.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • cytoplasm Source: RGD
  • lamellipodium Source: RGD
  • plasma membrane Source: RGD
  • presynapse Source: GOC
  • protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062841 – 594Syntaxin-binding protein 2Add BLAST594

Proteomic databases

PaxDbiQ62753.
PRIDEiQ62753.

PTM databases

iPTMnetiQ62753.
PhosphoSitePlusiQ62753.

Interactioni

Subunit structurei

Interacts with STX1A, STX2 and STX3. Interacts with STX11.By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: RGD
  • syntaxin-3 binding Source: RGD
  • syntaxin binding Source: RGD

Protein-protein interaction databases

BioGridi249662. 3 interactors.
DIPiDIP-289N.
STRINGi10116.ENSRNOP00000001322.

Structurei

3D structure databases

ProteinModelPortaliQ62753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1300. Eukaryota.
COG5158. LUCA.
HOGENOMiHOG000232146.
HOVERGENiHBG052710.
InParanoidiQ62753.
KOiK15300.
PhylomeDBiQ62753.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGLKAVV VEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI
60 70 80 90 100
LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK
110 120 130 140 150
AAHIFFTDTC PEPLFSELGR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP
160 170 180 190 200
HSTYNLYCPF RAGERGRQLD VLAQQIATLC ATLQEYPSIR YRKGPEDTAQ
210 220 230 240 250
LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ
260 270 280 290 300
AMAYDLLHIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
310 320 330 340 350
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA
360 370 380 390 400
DDCMKHFKGS VEKLCGVEQD LAMGSDAEGE KIKDTMKLIV PVLLDASVPP
410 420 430 440 450
YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQSYSNLIRN LEQLGGTVTN
460 470 480 490 500
SAGSGTSSRL ERRERMEPTY QLSRWSPVIK DVMEDVVEDR LDRKLWPFVS
510 520 530 540 550
DPAPVSSSQA AVSSARFGHW HKNKAGIEAR AGPRLIVYIV GGVAMSEMRA
560 570 580 590
AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LRTLDQKLED IALP
Length:594
Mass (Da):66,696
Last modified:November 1, 1996 - v1
Checksum:iB4956372A75F1637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20283 mRNA. Translation: AAA79516.1.
PIRiA57022.
RefSeqiNP_112388.1. NM_031126.1.
UniGeneiRn.10121.

Genome annotation databases

GeneIDi81804.
KEGGirno:81804.
UCSCiRGD:619967. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20283 mRNA. Translation: AAA79516.1.
PIRiA57022.
RefSeqiNP_112388.1. NM_031126.1.
UniGeneiRn.10121.

3D structure databases

ProteinModelPortaliQ62753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249662. 3 interactors.
DIPiDIP-289N.
STRINGi10116.ENSRNOP00000001322.

PTM databases

iPTMnetiQ62753.
PhosphoSitePlusiQ62753.

Proteomic databases

PaxDbiQ62753.
PRIDEiQ62753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81804.
KEGGirno:81804.
UCSCiRGD:619967. rat.

Organism-specific databases

CTDi6813.
RGDi619967. Stxbp2.

Phylogenomic databases

eggNOGiKOG1300. Eukaryota.
COG5158. LUCA.
HOGENOMiHOG000232146.
HOVERGENiHBG052710.
InParanoidiQ62753.
KOiK15300.
PhylomeDBiQ62753.

Miscellaneous databases

PROiQ62753.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB2_RAT
AccessioniPrimary (citable) accession number: Q62753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.