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Protein

Synaptotagmin-6

Gene

Syt6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi261 – 2611Calcium 1By similarity
Metal bindingi261 – 2611Calcium 2By similarity
Metal bindingi267 – 2671Calcium 1By similarity
Metal bindingi319 – 3191Calcium 1By similarity
Metal bindingi319 – 3191Calcium 2By similarity
Metal bindingi320 – 3201Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi321 – 3211Calcium 1By similarity
Metal bindingi321 – 3211Calcium 2By similarity
Metal bindingi321 – 3211Calcium 3By similarity
Metal bindingi324 – 3241Calcium 3By similarity
Metal bindingi327 – 3271Calcium 2By similarity
Metal bindingi327 – 3271Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-6
Alternative name(s):
Synaptotagmin VI
Short name:
SytVI
Gene namesi
Name:Syt6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi62012. Syt6.

Subcellular locationi

Isoform 1 :
  • Membrane By similarity; Single-pass membrane protein By similarity

  • Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity).By similarity
Isoform 2 :
  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959VesicularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 511431CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Synaptotagmin-6PRO_0000183956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei186 – 1861PhosphoserineBy similarity
Modified residuei217 – 2171PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ62746.
PRIDEiQ62746.

PTM databases

PhosphoSiteiQ62746.

Expressioni

Gene expression databases

ExpressionAtlasiQ62746. baseline and differential.
GenevisibleiQ62746. RN.

Interactioni

Subunit structurei

Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2: Is not able to form homodimer and heterodimers.By similarity

GO - Molecular functioni

  • clathrin binding Source: GO_Central
  • syntaxin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025953.

Structurei

3D structure databases

ProteinModelPortaliQ62746.
SMRiQ62746. Positions 231-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 333102C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 467104C2 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 3827Cysteine motifBy similarityAdd
BLAST
Regioni483 – 51129Necessary for cell membrane association (isoform 2)By similarityAdd
BLAST

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDM9. Eukaryota.
ENOG410YBMV. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ62746.
KOiK19906.
OMAiSTRHISF.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ62746.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028701. SYT6.
[Graphical view]
PANTHERiPTHR10024:SF45. PTHR10024:SF45. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGVWGAGGP RCQAALAVLA SLCRARPPPL GLDVETCQSF ELQPPEQSPS
60 70 80 90 100
AADSGTSVSL LAVVVIVCGV ALVAVFFFLF WKLCWMPWRN KEASSPSSAN
110 120 130 140 150
PASEILQSPS SRGNMADKLK DPSALGFLEA AVKISHTSPD IPAEVQMSVK
160 170 180 190 200
EHIMRHTKLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAAE
210 220 230 240 250
QPTSIGRIKP ELYKQKSVDG DEAKSEAAKS CGKINFSLRY DYESETLIVR
260 270 280 290 300
ILKAFDLPAK DFCGSSDPYV KIYLLPDRKC KLQTRVHRKT LNPTFDENFH
310 320 330 340 350
FPVPYEELAD RKLHLSVFDF DRFSRHDMIG EVILDNLFEA SDLSRETSIW
360 370 380 390 400
KDIQYATSES VDLGEIMFSL CYLPTAGRLT LTVIKCRNLK AMDITGYSDP
410 420 430 440 450
YVKVSLLCDG RRLKKKKTTI KKNTLNPVYN EAIIFDIPPE NMDQVSLLIS
460 470 480 490 500
VMDYDRVGHN EIIGVCRVGI SAEGLGRDHW NEMLAYPRKP IAHWHCLAEV
510
KKSFKEGTPR L
Length:511
Mass (Da):57,179
Last modified:November 1, 1996 - v1
Checksum:i17773C73BEC0FAF8
GO
Isoform 2 (identifier: Q62746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:426
Mass (Da):48,302
Checksum:i29A56EE064DCB14F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_041730Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20105 mRNA. Translation: AAA87724.1.
BC099185 mRNA. Translation: AAH99185.1.
PIRiS58399.
RefSeqiNP_071527.1. NM_022191.1. [Q62746-1]
UniGeneiRn.48074.

Genome annotation databases

EnsembliENSRNOT00000025953; ENSRNOP00000025953; ENSRNOG00000019163. [Q62746-1]
GeneIDi60565.
KEGGirno:60565.
UCSCiRGD:62012. rat. [Q62746-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20105 mRNA. Translation: AAA87724.1.
BC099185 mRNA. Translation: AAH99185.1.
PIRiS58399.
RefSeqiNP_071527.1. NM_022191.1. [Q62746-1]
UniGeneiRn.48074.

3D structure databases

ProteinModelPortaliQ62746.
SMRiQ62746. Positions 231-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025953.

PTM databases

PhosphoSiteiQ62746.

Proteomic databases

PaxDbiQ62746.
PRIDEiQ62746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025953; ENSRNOP00000025953; ENSRNOG00000019163. [Q62746-1]
GeneIDi60565.
KEGGirno:60565.
UCSCiRGD:62012. rat. [Q62746-1]

Organism-specific databases

CTDi148281.
RGDi62012. Syt6.

Phylogenomic databases

eggNOGiENOG410KDM9. Eukaryota.
ENOG410YBMV. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ62746.
KOiK19906.
OMAiSTRHISF.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ62746.

Miscellaneous databases

PROiQ62746.

Gene expression databases

ExpressionAtlasiQ62746. baseline and differential.
GenevisibleiQ62746. RN.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028701. SYT6.
[Graphical view]
PANTHERiPTHR10024:SF45. PTHR10024:SF45. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT6_RAT
AccessioniPrimary (citable) accession number: Q62746
Secondary accession number(s): Q4KLI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.