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Protein

CD81 antigen

Gene

Cd81

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
CD_antigen: CD81
Gene namesi
Name:Cd81
Synonyms:Tapa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2315. Cd81.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 115HelicalSequence analysisAdd BLAST26
Topological domaini116 – 201ExtracellularSequence analysisAdd BLAST86
Transmembranei202 – 226HelicalSequence analysisAdd BLAST25
Topological domaini227 – 236CytoplasmicSequence analysis10

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192241 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 190By similarity
Disulfide bondi157 ↔ 175By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62745.
PRIDEiQ62745.

PTM databases

iPTMnetiQ62745.
PhosphoSitePlusiQ62745.
SwissPalmiQ62745.

Interactioni

Subunit structurei

Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247650. 1 interactor.
STRINGi10116.ENSRNOP00000027760.

Structurei

3D structure databases

ProteinModelPortaliQ62745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ62745.
PhylomeDBiQ62745.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTTLLYLELG
60 70 80 90 100
DKPAPSTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF
160 170 180 190 200
HETLNCCGSN TLTTLTTAVL RNSLCPSSSN SFTQLLKEDC HQKIDELFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,889
Last modified:November 1, 1996 - v1
Checksum:iDCC48F38EB19BDF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19894 mRNA. Translation: AAC53103.1.
UniGeneiRn.1975.

Genome annotation databases

UCSCiRGD:2315. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19894 mRNA. Translation: AAC53103.1.
UniGeneiRn.1975.

3D structure databases

ProteinModelPortaliQ62745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247650. 1 interactor.
STRINGi10116.ENSRNOP00000027760.

PTM databases

iPTMnetiQ62745.
PhosphoSitePlusiQ62745.
SwissPalmiQ62745.

Proteomic databases

PaxDbiQ62745.
PRIDEiQ62745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2315. rat.

Organism-specific databases

RGDi2315. Cd81.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ62745.
PhylomeDBiQ62745.

Miscellaneous databases

PROiQ62745.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD81_RAT
AccessioniPrimary (citable) accession number: Q62745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.